High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy

Progress and problems with the use of viral vectors for gene therapy

2003 • 2,389 citations

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

1998 • 2,078 citations

Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma

1998 • 1,826 citations

Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains.

1994 • 1,400 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

1999 • 1,000 citations

DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES

1999 • 898 citations

A fresh look at tumor immunosurveillance and immunotherapy

2001 • 723 citations

Developmental and tissue-specific regulation of mouse telomerase and telomere length.

1995 • 686 citations

The Telomerase Catalytic Subunit Is a Widely Expressed Tumor-Associated Antigen Recognized by Cytotoxic T Lymphocytes

1999 • 574 citations

Heat Shock Protein–Peptide Complexes, Reconstituted In Vitro, Elicit Peptide-specific Cytotoxic T Lymphocyte Response and Tumor Immunity

1997 • 567 citations

Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues.

1996 • 566 citations

Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells

2000 • 544 citations

Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy.

1996 • 520 citations

gp100/pmel 17 Is a Murine Tumor Rejection Antigen: Induction of “Self”-reactive, Tumoricidal T Cells Using High-affinity, Altered Peptide Ligand

1998 • 490 citations

Enhanced Generation of Specific Tumor-Reactive CTL In Vitro by Selected Melan-A/MART-1 Immunodominant Peptide Analogues

1998 • 487 citations

HLA-A2.1–restricted Education and Cytolytic Activity of CD8+ T Lymphocytes from β2 Microglobulin (β2m) HLA-A2.1 Monochain Transgenic H-2Db β2m Double Knockout Mice

1997 • 486 citations

Melanocyte Destruction after Antigen-Specific Immunotherapy of Melanoma

2000 • 423 citations

Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase

1998 • 419 citations

High Avidity CTLs for Two Self-Antigens Demonstrate Superior In Vitro and In Vivo Antitumor Efficacy

1999 • 388 citations

Vaccination with a recombinant vaccinia virus encoding a “self” antigen induces autoimmune vitiligo and tumor cell destruction in mice: Requirement for CD4⁺T lymphocytes

1999 • 383 citations

Quantification of antigen specific CD8+ T cells using an ELISPOT assay

1995 • 367 citations

Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells.

2000 • 355 citations

Tolerance to p53 by A2.1-restricted Cytotoxic T Lymphocytes

1997 • 264 citations

Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes

1999 • 234 citations

Genes Coding for Tumor Antigens Recognized by Cytolytic T Lymphocytes

1995 • 233 citations

Tolerance to a self-protein involves its immunodominant but does not involve its subdominant determinants.

1992 • 219 citations

Chronic myelogenous leukemia shapes host immunity by selective deletion of high-avidity leukemia-specific T cells

2003 • 219 citations

Human tumor antigens recognized by T cells

1996 • 217 citations

Tumor Eradication by Wild-type p53-specific Cytotoxic T Lymphocytes

1997 • 215 citations

Induction of anti-self-immunity to cure cancer

1995 • 207 citations

Self-Tolerance to the Murine Homologue of a Tyrosinase-Derived Melanoma Antigen

2000 • 160 citations

Expression profile of the putative catalytic subunit of the telomerase gene.

1998 • 152 citations

Immunity to WT1 in the animal model and in patients with acute myeloid leukemia

2000 • 144 citations

A general strategy to enhance immunogenicity of low-affinity HLA-A2.1-associated peptides: implication in the identification of cryptic tumor epitopes

2000 • 129 citations

Dendritic cells break tolerance and induce protective immunity against a melanocyte differentiation antigen in an autologous melanoma model.

2000 • 127 citations

HER-2/neu and hTERT Cryptic Epitopes as Novel Targets for Broad Spectrum Tumor Immunotherapy

2002 • 121 citations

B7H Costimulates Clonal Expansion of, and Cognate Destruction of Tumor Cells by, CD8+ T Lymphocytes In Vivo

2001 • 120 citations

Identification of human telomerase reverse transcriptase–derived peptides that induce HLA-A24–restricted antileukemia cytotoxic T lymphocytes

2001 • 117 citations

Characterization of HLA-A3-restricted cytotoxic T lymphocytes reactive against the widely expressed tumor antigen telomerase.

2001 • 103 citations

Identification of HLA DR7-restricted epitopes from human telomerase reverse transcriptase recognized by CD4+ T-helper cells.

2002 • 95 citations

MHC class I-restricted epitope spreading in the context of tumor rejection following vaccination with a single immunodominant CTL epitope

1999 • 86 citations

Intensity of the Vaccine-Elicited Immune Response Determines Tumor Clearance

2002 • 83 citations

Assessment of Immunogenicity of Human Melan-A Peptide Analogues in HLA-A*0201/Kb Transgenic Mice

1999 • 65 citations

Adjuvant immunotherapy for solid tumors: from promise to clinical application

2002 • 58 citations

Chimeric peptides: a new approach to enhancing the immunogenicity of peptides with low MHC class I affinity: application in antiviral vaccination.

1997 • 49 citations

Chronic myelogenous leukemia shapes host immunity by selective deletion of high-avidity leukemia-specific T cells

2003 • 47 citations

Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant

2002 • 41 citations

The self-directed T cell repertoire: its creation and activation.

2000 • 37 citations