Multiple Distinct Sets of Stereotyped Antigen Receptors Indicate a Role for Antigen in Promoting Chronic Lymphocytic Leukemia

Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic Leukemia

1999 • 2,674 citations

Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic Leukemia

1999 • 2,557 citations

Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.

1998 • 899 citations

Genetic and Structural Evidence for Antigen Selection of Anti-DNA Antibodies

1994 • 464 citations

Autoreactivity by design: innate B and T lymphocytes

2001 • 409 citations

The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire

1994 • 390 citations

B‐cell subsets and the mature ­preimmune repertoire. Marginal zone and B1 B cells as part of a “natural immune memory”

2000 • 380 citations

B Cell Chronic Lymphocytic Leukemia: Lessons Learned from Studies of the B Cell Antigen Receptor

2003 • 377 citations

Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance

2001 • 348 citations

Monoclonal B lymphocytes with the characteristics of “indolent” chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts

2002 • 341 citations

Somatically mutated Ig VH3-21 genes characterize a new subset of chronic lymphocytic leukemia

2002 • 335 citations

Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vλ2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope

2003 • 318 citations

Expressed Murine and Human CDR-H3 Intervals of Equal Length Exhibit Distinct Repertoires that Differ in their Amino Acid Composition and Predicted Range of Structures

2003 • 316 citations

Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia.

1989 • 290 citations

Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance

2001 • 277 citations

Antigen-Binding Myeloma Proteins of Mice

1978 • 272 citations

Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia

2004 • 240 citations

Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia.

1989 • 239 citations

Gastric MALT lymphoma: From concept to cure

1999 • 237 citations

Monoclonal CD5+ and CD5- B-lymphocyte expansions are frequent in the peripheral blood of the elderly

2003 • 235 citations

Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features.

1997 • 230 citations

Evidence that chronic lymphocytic leukemia B lymphocytes are frequently committed to production of natural autoantibodies

1990 • 222 citations

VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities.

1992 • 214 citations

Chronic Lymphoid Leukemias

2001 • 112 citations

HTLV-I—Associated B-Cell CLL: Indirect Role for Retrovirus in Leukemogenesis

1987 • 108 citations

Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. III. A single VKII gene and one of several JK genes are joined by an invariant arginine to form the most common L chain V region.

1989 • 86 citations

Immunoglobulin V region gene use and structure suggest antigen selection in AIDS-related primary effusion lymphomas

1999 • 83 citations

Idiotypic and subgroup analysis of human monoclonal rheumatoid factors. Implications for structural and genetic basis of autoantibodies in humans.

1988 • 78 citations

Frequent occurrence of identical heavy and light chain Ig rearrangements

1997 • 64 citations

CD5-positive B cells in healthy elderly humans are a polyclonal B cell population

2000 • 33 citations

VH3-21 B Cells Escape from a State of Tolerance in Rheumatoid Arthritis and Secrete Rheumatoid Factor

1995 • 31 citations

Anti-cardiolipin/β-2 glycoprotein activities co-exist on human anti-DNA antibody light chains

2003 • 5 citations