Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene

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2003 • 2,949 citations

Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic Leukemia

1999 • 2,674 citations

Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic Leukemia

1999 • 2,557 citations

National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment

1996 • 1,906 citations

ZAP-70 Expression as a Surrogate for Immunoglobulin-Variable-Region Mutations in Chronic Lymphocytic Leukemia

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Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.

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Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells.

1997 • 373 citations

The Immunoglobulin FactsBook

2001 • 361 citations

Somatically mutated Ig VH3-21 genes characterize a new subset of chronic lymphocytic leukemia

2002 • 335 citations

Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vλ2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope

2003 • 318 citations

Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia

2004 • 280 citations

The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression

2003 • 268 citations

Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins

2004 • 258 citations

Relationship between p53 dysfunction, CD38 expression, andIgVH mutation in chronic lymphocytic leukemia

2002 • 252 citations

Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia

2004 • 240 citations

Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia.

1989 • 239 citations

Description of a novel FR1 IgH PCR strategy and its comparison with three other strategies for the detection of clonality in B cell malignancies.

1995 • 188 citations

The Inference of Antigen Selection on Ig Genes

2000 • 186 citations

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Binet’s Staging System and VH Genes Are Independent but Complementary Prognostic Indicators in Chronic Lymphocytic Leukemia

2003 • 97 citations

Prognostic Factors and Clinical Staging in Chronic Lymphocytic Leukemia

1990 • 63 citations

Follicular lymphoma immunoglobulin κ light chains are affected by the antigen selection process, but to a lesser degree than their partner heavy chains

1997 • 61 citations

Polymorphism and Utilization of Human V_H Genes^a

1995 • 51 citations

High frequency of somatic mutations in the VH genes expressed in prolymphocytic leukemia

1996 • 40 citations

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Immunobiology of chronic lymphocytic leukemia

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Connection between Immunosuppressants and Steroids via HSP90

1995 • 13 citations