Plasminogen activator inhibitor-1 and vitronectin promote vascular thrombosis in mice

Increased Plasma Levels of a Rapid Inhibitor of Tissue Plasminogen Activator in Young Survivors of Myocardial Infarction

1985 • 1,364 citations

Lewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology.

1994 • 862 citations

The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin

1996 • 680 citations

Basic and clinical aspects of fibrinolysis and thrombolysis

1991 • 653 citations

Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene.

1996 • 559 citations

Purification and characterization of a plasminogen activator inhibitor 1 binding protein from human plasma. Identification as a multimeric form of S protein (vitronectin).

1988 • 484 citations

Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis.

1993 • 399 citations

Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization.

1993 • 344 citations

Complete Deficiency of Plasminogen-Activator Inhibitor Type 1 Due to a Frame-Shift Mutation

1992 • 267 citations

Type 1 plasminogen activator inhibitor

1990 • 244 citations

Bleeding diathesis due to decreased functional activity of type 1 plasminogen activator inhibitor.

1989 • 208 citations

Regulation of Arterial Thrombolysis by Plasminogen Activator Inhibitor-1 in Mice

1998 • 203 citations

Vascular wound healing and neointima formation induced by perivascular electric injury in mice.

1997 • 203 citations

Vitronectin is not essential for normal mammalian development and fertility.

1995 • 188 citations

The Fibrinolytic Enzyme System and Its Role in the Etiology of Thromboembolic Disease

1990 • 165 citations

A lifelong bleeding disorder associated with a deficiency of plasminogen activator inhibitor type 1

1991 • 153 citations

Platelets inhibit fibrinolysis in vitro by both plasminogen activator inhibitor-1-dependent and -independent mechanisms

1994 • 140 citations

Vitronectin Inhibits the Thrombotic Response to Arterial Injury in Mice

1999 • 114 citations

Type 1 plasminogen activator inhibitor

1990 • 113 citations

Photochemically induced thrombosis model in rat femoral artery and evaluation of effects of heparin and tissue-type plasminogen activator with use of this model

1991 • 112 citations

Platelets inhibit fibrinolysis in vitro by both plasminogen activator inhibitor-1-dependent and -independent mechanisms

1994 • 112 citations

Thrombolysis and Reocclusion in Experimental Jugular Vein and Coronary Artery Thrombosis

1995 • 108 citations

Stimulation of migration of human aortic smooth muscle cells by vitronectin: implications for atherosclerosis

1994 • 107 citations

Peptide-mediated inactivation of recombinant and platelet plasminogen activator inhibitor-1 in vitro.

1995 • 100 citations

A New Animal Model of Thrombophilia Confirms that High Plasma Factor VIII Levels Are Thrombogenic

1999 • 82 citations

Photochemically Induced Endothelial Injury in the Mouse as a Screening Model for Inhibitors of Vascular Intimal Thickening

1998 • 73 citations

Differential Role of Components of the Fibrinolytic System in the Formation and Removal of Thrombus Induced by Endothelial Injury

1999 • 71 citations

Genetic Analysis Of The Plasminogen And Coagulation System In Mice

1996 • 35 citations

Arterial thrombosis model with photochemical reaction in guinea-pig and its property

1992 • 26 citations

Beneficial effect of CV-4151 (isbogrel), a thromboxane A2 synthase inhibitor, in a rat middle cerebral artery thrombosis model

1995 • 11 citations