Selective inactivation by 21-chlorinated steroids of rabbit liver and adrenal microsomal cytochromes P-450 involved in progesterone hydroxylation

The P450 Gene Superfamily: Recommended Nomenclature

1987 • 812 citations

Enzyme-Activated Irreversible Inhibitors

1979 • 420 citations

Enzymatic activation of chemicals to toxic metabolites

1985 • 331 citations

Induction of microsomal cytochrome P-450 enzymes: The first Bernard B. Brodie lecture at Pennsylvania State University

1986 • 161 citations

Cytochromes P-450 and the regulation of steroid synthesis

1986 • 146 citations

Regioselectivity in the cytochromes P-450: Control by protein constraints and by chemical reactivities

1984 • 140 citations

Chemical Mechanisms of Halocarbon Metabolism

1983 • 107 citations

Specific inactivation of hepatic fatty acid hydroxylases by acetylenic fatty acids.

1984 • 103 citations

Multiple gene-like sequences related to the rabbit hepatic progesterone 21-hydroxylase cytochrome P-450 1.

1985 • 86 citations

Mechanism-based enzyme inactivators.

1984 • 83 citations

Covalent modification of lysine during the suicide inactivation of rat liver cytochrome P-450 by chloramphenicol

1981 • 75 citations

Identification of rabbit microsomal cytochrome P-450 isozyme, form 1, as a hepatic progesterone 21-hydroxylase

1982 • 73 citations

Inhibition and inactivation of estrogen synthetase (aromatase) by fluorinated substrate analogs

1982 • 69 citations

Functional and structural polymorphism of rabbit microsomal cytochrome P-450 form 3b.

1982 • 68 citations

Evidence for functional and structural multiplicity of pregnenolone-16.alpha.-carbonitrile-inducible cytochrome P-450 isozymes in rat liver microsomes

1987 • 54 citations

Study of the mechanism of metabolic activation of chloramphenicol by rat liver microsomes

1978 • 51 citations

Three monoclonal antibodies to rabbit microsomal cytochrome P-450 1 recognize distinct epitopes that are shared to different degrees among other electrophoretic types of cytochrome P-450.

1984 • 48 citations

Acetylenic mechanism-based inhibitors of cholesterol side chain cleavage by cytochrome P-450scc.

1983 • 40 citations

Isozyme selectivity of the inhibition of rat liver cytochromes P-450 by chloramphenicol in vivo.

1985 • 38 citations

Analogues of chloramphenicol as mechanism-based inactivators of rat liver cytochrome P-450: modifications of the propanediol side chain, the p-nitro group, and the dichloromethyl moiety.

1986 • 33 citations

Role of 21-hydroxypregnenolone and of 17α-, 21-dihydroxypregnenolone in the biogenesis of C21 and C19 steroids by adrenal gland slices

1964 • 32 citations

Dichloromethyl compounds as mechanism-based inactivators of rat liver cytochromes P-450 in vitro.

1986 • 30 citations

Variations in hepatic progesterone 21-hydroxylase activity reflect differences in the microsomal concentration of rabbit cytochrome P-450 1

1985 • 26 citations

A new method for the selective halogenation of the methyl group of methyl ketones

1970 • 25 citations

Two catalytically distinct subforms of cytochrome P-450 3b as obtained from inbred rabbits

1985 • 22 citations

Selective inactivation of four rat liver microsomal androstenedione hydroxylases by chloramphenicol analogs.

1988 • 21 citations

Inductive and repressive effects of rifampicin on rabbit liver microsomal cytochrome P-450

1984 • 21 citations

Active site-directed inhibition of rabbit cytochrome P-450 1 by amino-substituted steroids.

1986 • 19 citations

Isolation and partial characterization of a rifampicin induced rabbit liver microsomal cytochrome P-450

1985 • 18 citations

Discriminatory inhibition of adrenocortical 17α-hydroxylase activity by inhibitors of cholesterol side chain cleavage cytochrome P-450

1985 • 13 citations

Intraspecies individuality for the metabolism of steroids

1987 • 9 citations