Caveolin-1 regulates shear stress-dependent activation of extracellular signal-regulated kinase

Functional rafts in cell membranes

1997 • 9,471 citations

Mechanotransduction Across the Cell Surface and Through the Cytoskeleton

1993 • 2,947 citations

Flow-mediated endothelial mechanotransduction

1995 • 2,728 citations

THE CAVEOLAE MEMBRANE SYSTEM

1998 • 1,947 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

1998 • 1,502 citations

Identification of Peptide and Protein Ligands for the Caveolin-scaffolding Domain

1997 • 909 citations

VIP21/caveolin is a cholesterol-binding protein.

1995 • 892 citations

A Requirement for Caveolin-1 and Associated Kinase Fyn in Integrin Signaling and Anchorage-Dependent Cell Growth

1998 • 720 citations

Expression of Caveolin-3 in Skeletal, Cardiac, and Smooth Muscle Cells

1996 • 692 citations

Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element.

1993 • 638 citations

Effects of Mechanical Forces on Signal Transduction and Gene Expression in Endothelial Cells

1998 • 582 citations

Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.

1996 • 566 citations

The plasma membrane

1983 • 561 citations

Fluid Shear Stress Activation of Focal Adhesion Kinase

1997 • 412 citations

Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors

1994 • 404 citations

A Role for Caveolin and the Urokinase Receptor in Integrin-mediated Adhesion and Signaling

1999 • 402 citations

Caveolin Isoforms Differ in Their N-terminal Protein Sequence and Subcellular Distribution. IDENTIFICATION AND EPITOPE MAPPING OF AN ISOFORM-SPECIFIC MONOCLONAL ANTIBODY PROBE

1995 • 362 citations

Biomechanical activation: an emerging paradigm in endothelial adhesion biology.

1997 • 348 citations

Modulation of GTPase activity of G proteins by fluid shear stress and phospholipid composition

1998 • 344 citations

Nuclear factor-kappa B interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress.

1995 • 343 citations

Caveolin-1 and -2 in the Exocytic Pathway of MDCK Cells

1998 • 303 citations

Fluid Shear Stress Stimulates Mitogen-Activated Protein Kinase in Endothelial Cells

1995 • 287 citations

Separation of “Glycosphingolipid Signaling Domain” from Caveolin-containing Membrane Fraction in Mouse Melanoma B16 Cells and Its Role in Cell Adhesion Coupled with Signaling

1998 • 284 citations

Stimulation of Transcription Factors NFκB and AP1 in Endothelial Cells Subjected to Shear Stress

1994 • 271 citations

Differential Effect of Shear Stress on Extracellular Signal-regulated Kinase and N-terminal Jun Kinase in Endothelial Cells

1997 • 269 citations

The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression.

1995 • 267 citations

Caveolae from luminal plasmalemma of rat lung endothelium: microdomains enriched in caveolin, Ca(2+)-ATPase, and inositol trisphosphate receptor.

1995 • 250 citations

Shear Stress Activates p60src-Ras-MAPK Signaling Pathways in Vascular Endothelial Cells

1998 • 239 citations

The Ras-JNK Pathway Is Involved in Shear-Induced Gene Expression

1996 • 234 citations

MAP Kinase Activation by Flow in Endothelial Cells

1996 • 224 citations

Mitogen-activated protein kinase (ERK1/2) activation by shear stress and adhesion in endothelial cells. Essential role for a herbimycin-sensitive kinase.

1996 • 217 citations

Pulsatile and steady flow induces c‐fos expression in human endothelial cells

1993 • 203 citations

Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway.

1998 • 196 citations

Rapid Mechanotransduction in Situ at the Luminal Cell Surface of Vascular Endothelium and Its Caveolae

1998 • 191 citations

Molecular Genetics of the Caveolin Gene Family: Implications for Human Cancers, Diabetes, Alzheimer Disease, and Muscular Dystrophy

1998 • 184 citations

Plasma Membrane Cholesterol Is a Key Molecule in Shear Stress-dependent Activation of Extracellular Signal-regulated Kinase

1998 • 182 citations

Fluid Shear Stress Stimulates Big Mitogen-activated Protein Kinase 1 (BMK1) Activity in Endothelial Cells

1999 • 179 citations

Regulation of G Protein-coupled Receptor Kinases by Caveolin

1999 • 173 citations

MEKK-1, a Component of the Stress (Stress-activated Protein Kinase/c-Jun N-terminal Kinase) Pathway, Can Selectively Activate Smad2-mediated Transcriptional Activation in Endothelial Cells

1999 • 171 citations

Endothelial albumin permeability is shear dependent, time dependent, and reversible

1991 • 166 citations

Mutational Analysis of the Properties of Caveolin-1

1997 • 164 citations

Evidence for peroxynitrite as a signaling molecule in flow-dependent activation of c-Jun NH₂-terminal kinase

1999 • 155 citations

A Role for the Caveolin Scaffolding Domain in Mediating the Membrane Attachment of Caveolin-1

1999 • 147 citations

PKC-ε Is Required for Mechano-sensitive Activation of ERK1/2 in Endothelial Cells

1997 • 122 citations

Immunoisolation of Caveolae with High Affinity Antibody Binding to the Oligomeric Caveolin Cage

1999 • 116 citations

Phosphatidylinositol 3-kinase γ mediates shear stress-dependent activation of JNK in endothelial cells

1998 • 87 citations