Molecular Motors and Cell Motility in the Brain

Complementary DNA Sequencing: Expressed Sequence Tags and Human Genome Project

1991 • 2,286 citations

Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility

1985 • 1,930 citations

The Fine Structure of the Nervous System: Neurons and Their Supporting Cells

1991 • 1,522 citations

ACTIN AND ACTIN-BINDING PROTEINS. A CRITICAL EVALUATION OF MECHANISMS AND FUNCTIONS

1986 • 1,493 citations

Electron microscope studies on the structure of natural and synthetic protein filaments from striated muscle

1963 • 1,452 citations

Cytoskeletal dynamics and nerve growth

1988 • 855 citations

Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone.

1988 • 851 citations

Polarity orientation of microtubules in hippocampal neurons: uniformity in the axon and nonuniformity in the dendrite.

1988 • 716 citations

Exchange of actin subunits at the leading edge of living fibroblasts: possible role of treadmilling.

1985 • 637 citations

A novel brain ATPase with properties expected for the fast axonal transport motor

1985 • 604 citations

Microtubule-Associated Proteins: Their Potential Role in Determining Neuronal Morphology

1988 • 599 citations

MAP 1C is a microtubule-activated ATPase which translocates microtubules in vitro and has dynein-like properties.

1987 • 563 citations

Retrograde transport by the microtubule-associated protein MAP 1C

1987 • 547 citations

Novel myosin heavy chain encoded by murine dilute coat colour locus

1991 • 534 citations

The periodic association of MAP2 with brain microtubules in vitro.

1979 • 510 citations

Localization of cytoplasmic dynein to mitotic spindles and kinetochores

1990 • 508 citations

KAR3, a kinesin-related gene required for yeast nuclear fusion

1990 • 504 citations

Cytoplasmic dynein is localized to kinetochores during mitosis

1990 • 486 citations

Structure and Utilization of Tubulin Isotypes

1988 • 474 citations

The Actin-Binding Protein Profilin Binds to PIP ₂ and Inhibits Its Hydrolysis by Phospholipase C

1990 • 472 citations

The Saccharomyces cerevisiae MYO2 gene encodes an essential myosin for vectorial transport of vesicles.

1991 • 471 citations

Submolecular domains of bovine brain kinesin identified by electron microscopy and monoclonal antibody decoration

1989 • 460 citations

Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling

1993 • 447 citations

Actin Polymerization and ATP Hydrolysis

1987 • 439 citations

Brain myosin-V is a two-headed unconventional myosin with motor activity

1993 • 432 citations

CENP-E is a putative kinetochore motor that accumulates just before mitosis

1992 • 424 citations

Microtubules

1984 • 405 citations

Mutation of a gene that encodes a kinesin-like protein blocks nuclear division in A. nidulans

1990 • 404 citations

A three-domain structure of kinesin heavy chain revealed by DNA sequence and microtubule binding analyses

1989 • 392 citations

Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome

1981 • 391 citations

Unconventional myosins

1992 • 374 citations

Actin-dependent organelle movement in squid axoplasm

1992 • 370 citations

Novel potential mitotic motor protein encoded by the fission yeast cut7+ gene

1990 • 366 citations

The roles of microtubule-associated proteins in brain morphogenesis: a review

1990 • 352 citations

The Drosophila claret segregation protein is a minus-end directed motor molecule

1990 • 345 citations

Primary structure and cellular localization of chicken brain myosin-V (p190), an unconventional myosin with calmodulin light chains.

1992 • 345 citations

The kinesin-like ncd protein of Drosophila is a minus end-directed microtubule motor

1990 • 335 citations

Dynein is the motor for retrograde axonal transport of organelles.

1989 • 334 citations

Fast Axonal Transport in Extruded Axoplasm from Squid Giant Axon

1982 • 333 citations

Neuronal Cytomechanics: The Actin-Based Motility of Growth Cones

1988 • 331 citations

Cytoplasmic dynein is a minus end-directed motor for membranous organelles

1989 • 313 citations

Kinesin family in murine central nervous system.

1992 • 310 citations

The Drosophila ninaC locus encodes two photoreceptor cell specific proteins with domains homologous to protein kinases and the myosin heavy chain head

1988 • 306 citations

Nerve growth cone lamellipodia contain two populations of actin filaments that differ in organization and polarity.

1992 • 305 citations

The control of actin nucleotide exchange by thymosin beta 4 and profilin. A potential regulatory mechanism for actin polymerization in cells.

1992 • 285 citations

Native structure and physical properties of bovine brain kinesin and identification of the ATP-binding subunit polypeptide

1988 • 284 citations

Radial extension of macrophage tubular lysosomes supported by kinesin

1990 • 276 citations

Polarity of actin at the leading edge of cultured cells

1978 • 268 citations

Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cells.

1987 • 267 citations

Novel heterotrimeric kinesin-related protein purified from sea urchin eggs

1993 • 263 citations

Microtubule-associated protein 1C from brain is a two-headed cytosolic dynein

1988 • 263 citations

Kinesin-related cut 7 protein associates with mitotic and meiotic spindles in fission yeast

1992 • 262 citations

Brain dynein (MAP1C) localizes on both anterogradely and retrogradely transported membranous organelles in vivo.

1990 • 261 citations

Monoclonal antibodies to kinesin heavy and light chains stain vesicle-like structures, but not microtubules, in cultured cells.

1989 • 261 citations

Phylogenetic analysis of the myosin superfamily

1993 • 258 citations

Kinesin associates with anterogradely transported membranous organelles in vivo.

1991 • 254 citations

In pursuit of myosin function.

1989 • 252 citations

Requirement of Microfilaments in Sorting of Actin Messenger RNA

1991 • 252 citations

MYOSIN-I

1991 • 252 citations

Are tubulin isotypes functionally significant.

1993 • 250 citations

A monoclonal antibody against kinesin inhibits both anterograde and retrograde fast axonal transport in squid axoplasm.

1990 • 242 citations

Widespread distribution of the major polypeptide component of MAP 1 (microtubule-associated protein 1) in the nervous system.

1984 • 238 citations

Identification of globular mechanochemical heads of kinesin

1989 • 231 citations

Multiple nucleotide-binding sites in the sequence of dynein β heavy chain

1991 • 229 citations

Mediation of meiotic and early mitotic chromosome segregation in Drosophila by a protein related to kinesin

1990 • 229 citations

The C. elegans unc-104 4 gene encodes a putative kinesin heavy chain-like protein

1991 • 220 citations

Identification of a microtubule-based cytoplasmic motor in the nematode C. elegans

1987 • 218 citations

Bovine brain kinesin is a microtubule-activated ATPase.

1986 • 215 citations

Chicken nonmuscle myosin heavy chains: differential expression of two mRNAs and evidence for two different polypeptides.

1991 • 211 citations

A kinesin-like protein required for distributive chromosome segregation in Drosophila

1990 • 209 citations

Microtubule Dynamics and Kinetochore Function in Mitosis

1988 • 208 citations

Analysis of microspike movements on the neuronal growth cone

1985 • 205 citations

Kinesin heavy chain is essential for viability and neuromuscular functions in Drosophila, but mutants show no defects in mitosis

1991 • 197 citations

Video microscopy of fast axonal transport in extruded axoplasm: A new model for study of molecular mechanisms

1985 • 193 citations

Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells

1992 • 193 citations

Unpolymerized actin in fibroblasts and brain

1976 • 186 citations

Attachment of transported vesicles to microtubules in axoplasm is facilitated by AMP-PNP

1985 • 184 citations

The distribution, abundance and subcellular localization of kinesin.

1989 • 179 citations

The quaternary structure of bovine brain kinesin.

1988 • 178 citations

Tissue distribution and subcellular localization of mammalian myosin I.

1992 • 175 citations

Four ATP-binding sites in the midregion of the β heavy chain of dynein

1991 • 175 citations

Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued

1991 • 174 citations

THE EFFECTS OF GENOTYPE AND CELL ENVIRONMENT ON MELANOBLAST DIFFERENTIATION IN THE HOUSE MOUSE

1956 • 173 citations

Identification and characterization of a gene encoding a kinesin-like protein in Drosophila

1990 • 172 citations

Molecular evolution of the myosin family: relationships derived from comparisons of amino acid sequences.

1993 • 164 citations

Novel form of growth cone motility involving site-directed actin filament assembly

1992 • 156 citations

Characterization of the microtubule movement produced by sea urchin egg kinesin.

1987 • 153 citations

The unconventional myosin encoded by the myoA gene plays a role in Dictyostelium motility.

1993 • 148 citations

Actin dynamics in growth cones

1991 • 145 citations

Cloning by Differential Screening of a Xenopus cDNA That Encodes a Kinesin-Related Protein

1991 • 143 citations

Myosin IB null mutants of Dictyostelium exhibit abnormalities in motility

1991 • 143 citations

Characterization of the microtubule-activated ATPase of brain cytoplasmic dynein (MAP 1C).

1988 • 142 citations

Dependence of Calmodulin Localization in the Retina on the NINAC Unconventional Myosin

1993 • 142 citations

Molecular motors in the nervous system

1991 • 141 citations

Association of kinesin with characterized membrane‐bounded organelles

1992 • 135 citations

Dynein from Dictyostelium: primary structure comparisons between a cytoplasmic motor enzyme and flagellar dynein.

1992 • 129 citations

Extension of filopodia by motor‐dependent actin assembly

1992 • 127 citations

Evidence for inserted sequences in the head region of nonmuscle myosin specific to the nervous system. Cloning of the cDNA encoding the myosin heavy chain-B isoform of vertebrate nonmuscle myosin.

1992 • 121 citations

Human nonmuscle myosin heavy chain mRNA: generation of diversity through alternative polyadenylylation.

1990 • 121 citations

Small actin-binding proteins: the β-thymosin family

1993 • 119 citations

Molecular genetics of kinesin light chains: generation of isoforms by alternative splicing.

1991 • 119 citations

Cloning by differential screening of a Xenopus cDNA that encodes a kinesin-related protein.

1991 • 118 citations

Effects of Kinesin Mutations on Neuronal Functions

1992 • 117 citations

Molecular cloning of the retrograde transport motor cytoplasmic dynein (MAP 1C)

1993 • 117 citations

Centripetal transport of cytoplasm, actin, and the cell surface in lamellipodia of fibroblasts

1988 • 115 citations

Subcellular localization and sequence of sea urchin kinesin heavy chain: evidence for its association with membranes in the mitotic apparatus and interphase cytoplasm [published erratum appears in J Cell Biol 1991 Aug;114(4):following 863]

1991 • 112 citations

Specific cleavage of dynein heavy chains by ultraviolet irradiation in the presence of ATP and vanadate.

1986 • 111 citations

Correlation between the ATPase and microtubule translocating activities of sea urchin egg kinesin

1987 • 110 citations

The unconventional myosin, Myo2p, is a calmodulin target at sites of cell growth in Saccharomyces cerevisiae

1994 • 109 citations

Dendrites of mitral cell neurons contain microtubules of opposite polarity

1988 • 108 citations

Identification, characterization and cloning of myr 1, a mammalian myosin-I.

1993 • 107 citations

The role of dynein in retrograde axonal transport

1989 • 101 citations

The Drosophila kinesin light chain. Primary structure and interaction with kinesin heavy chain

1993 • 100 citations

Dynein ATPases as microtubule motors.

1988 • 98 citations

Kinesin from pig brain studied by electron microscopy

1987 • 96 citations

Isolation of a 45-kDa Fragment from the Kinesin Heavy Chain with Enhanced ATPase and Microtubule-binding Activities

1989 • 96 citations

Myosin II distribution in neurons is consistent with a role in growth cone motility but not synaptic vesicle mobilization

1992 • 94 citations

Concentration of membrane antigens by forward transport and trapping in neuronal growth cones

1990 • 94 citations

Cloning by insertional mutagenesis of a cDNA encoding Caenorhabditis elegans kinesin heavy chain.

1993 • 94 citations

The primary structure and analysis of the squid kinesin heavy chain.

1990 • 92 citations

Isolation and characterization of the gene encoding the heavy chain of Drosophila kinesin.

1988 • 92 citations

Copurification of kinesin polypeptides with microtubule‐stimulated Mg‐ATPase activity and kinetic analysis of enzymatic properties

1989 • 90 citations

Identification and partial characterization of six members of the kinesin superfamily in Drosophila.

1991 • 90 citations

Purification and characterization of a mammalian myosin I.

1992 • 89 citations

Frozen tissue sections as an experimental system to reveal specific binding sites for the regulatory subunit of type II cAMP-dependent protein kinase in neurons.

1982 • 89 citations

Roles of actin filaments and three second‐messenger systems in short‐term regulation of chick dorsal root ganglion neurite outgrowth

1991 • 89 citations

Direct Chemical Evidence that Serine 180 in the Glycine-Rich Loop of Myosin Binds to ATP

1989 • 88 citations

<b>THE CYTOSKELETON IN MYELINATED AXONS: SERIAL SECTION </b><b>STUDY </b>

1981 • 87 citations

The wily ways of a parasite: induction of actin assembly by Listeria

1993 • 87 citations

Mitotic motors.

1991 • 85 citations

Evidence for myosin motors on organelles in squid axoplasm.

1993 • 83 citations

Genetic Approaches to Molecular Motors

1992 • 80 citations

A QUANTITATIVE HISTOLOGICAL STUDY OF THE PIGMENT FOUND IN THE COAT-COLOR MUTANTS OF THE HOUSE MOUSE. IV. THE NATURE OF THE EFFECTS OF GENIC SUBSTITUTION IN FIVE MAJOR ALLELIC SERIES

1949 • 80 citations

Immunolocalization of kinesin in sea urchin coelomocytes: Association of kinesin with intracellular organelles

1992 • 79 citations

Roles of kinesin and kinesin-like proteins in sea urchin embryonic cell division: evaluation using antibody microinjection.

1993 • 79 citations

Axonemal dyneins

1992 • 75 citations

Calcium-regulated cooperative binding of the microvillar 110K-calmodulin complex to F-actin: formation of decorated filaments.

1987 • 74 citations

In situ localization of myosin and actin in dendritic spines with the immunogold technique

1989 • 74 citations

Mammalian myosin I alpha, I beta, and I gamma: new widely expressed genes of the myosin I family.

1993 • 73 citations

Molecular genetic dissection of myosin heavy chain function

1990 • 73 citations

A multimember kinesin gene family in Drosophila.

1991 • 69 citations

Cytoplasmic dynein is a vesicle protein.

1992 • 64 citations

A lethal allele of dilute in the house mouse

1952 • 62 citations

The emerging kinesin family of microtubule motor proteins

1991 • 60 citations

Axonal tubulin and microtubules: Morphologic evidence for stable regions on axonal microtubules

1987 • 56 citations

Domain structure of a mammalian myosin I beta.

1994 • 55 citations

Sequences of Sea Urchin Kinesin Light Chain Isoforms

1993 • 51 citations

Chromosome motion in mitosis

1992 • 44 citations

Multiple Kinesin-like Transcripts in Xenopus Oocytes

1993 • 43 citations

Multiple Kinesin-related Proteins in Yeast Mitosis

1991 • 43 citations

Photocleavage of myosin subfragment 1 by vanadate

1990 • 43 citations

Binding of dynein 21 S ATPase to microtubules. Effects of ionic conditions and substrate analogs.

1981 • 43 citations

The axonal transport motor ‘kinesin’ is bound to anterogradely transported organelles: quantitative cytofluorimetric studies of fast axonal transport in the rat

1991 • 35 citations

Mitosis: Spindle assembly and chromosome motion

1993 • 34 citations

Myelination and myelin degeneration in the central nervous system of dilute-lethal mice

1962 • 32 citations

A squid dynein isoform promotes axoplasmic vesicle translocation.

1989 • 29 citations

Homology of egg and flagellar dynein. Comparison of ATP-binding sites and primary structure.

1986 • 27 citations

Retinoic Acid Regulates Thymosin β Levels in Rat Neuroblastoma Cells

1991 • 25 citations

Effects of AMPPNP and vanadate on the mechanochemical crossbridge cycle in flagella

1981 • 19 citations

Chromosome distribution, molecular motors and the claret protein

1993 • 19 citations

Meiotic chromosome distribution in Drosophila oocytes: Roles of two kinesin-related proteins

1992 • 18 citations

Molecular cloning of a mouse myosin I expressed in brain

1993 • 9 citations

Cytotypic Specialization of the Neuronal Cytoskeleton and the Cytomatrix: Implications for Neuronal Growth and Regeneration

1988 • 7 citations

Localization of the human kinesin-related gene to band 10q24 by fluorescence in situ hybridization

1992 • 6 citations

Kinesin-like Proteins of Aspergillus nidulans

1991 • 4 citations

Deleted Work

1955 • 0 citations