Mitosis: Spindle assembly and chromosome motion

Dynamic instability of microtubule growth

1984 • 3,187 citations

Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies.

1988 • 985 citations

Cell Motility by Labile Association of Molecules

1967 • 767 citations

Mitotic spindle organization by a plus-end-directed microtubule motor

1992 • 643 citations

Polewards microtubule flux in the mitotic spindle: evidence from photoactivation of fluorescence.

1989 • 603 citations

Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles : Implications for the role of microtubule dynamics in mitosis

1992 • 521 citations

Localization of cytoplasmic dynein to mitotic spindles and kinetochores

1990 • 508 citations

KAR3, a kinesin-related gene required for yeast nuclear fusion

1990 • 504 citations

Tubulin dynamics in cultured mammalian cells.

1984 • 489 citations

Kinetochores are transported poleward along a single astral microtubule during chromosome attachment to the spindle in newt lung cells.

1990 • 488 citations

Cytoplasmic dynein is localized to kinetochores during mitosis

1990 • 486 citations

Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein.

1991 • 482 citations

CENP-E is a putative kinetochore motor that accumulates just before mitosis

1992 • 424 citations

Polewards chromosome movement driven by microtubule depolymerization in vitro

1988 • 409 citations

Mutation of a gene that encodes a kinesin-like protein blocks nuclear division in A. nidulans

1990 • 404 citations

Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly.

1992 • 401 citations

Kinesin-related proteins required for structural integrity of the mitotic spindle

1992 • 374 citations

A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles

1992 • 356 citations

Kinesin-related proteins required for assembly of the mitotic spindle.

1992 • 347 citations

The Drosophila claret segregation protein is a minus-end directed motor molecule

1990 • 345 citations

The kinesin-like ncd protein of Drosophila is a minus end-directed microtubule motor

1990 • 335 citations

Cell division and the mitotic spindle.

1981 • 323 citations

Kinetochores capture astral microtubules during chromosome attachment to the mitotic spindle: direct visualization in live newt lung cells.

1990 • 312 citations

Oscillatory movements of monooriented chromosomes and their position relative to the spindle pole result from the ejection properties of the aster and half-spindle.

1986 • 302 citations

Taxol-induced microtubule asters in mitotic extracts of Xenopus eggs: requirement for phosphorylated factors and cytoplasmic dynein.

1991 • 300 citations

Spindle microtubule dynamics in sea urchin embryos: analysis using a fluorescein-labeled tubulin and measurements of fluorescence redistribution after laser photobleaching.

1984 • 291 citations

Poleward kinetochore fiber movement occurs during both metaphase and anaphase-A in newt lung cell mitosis.

1992 • 271 citations

Kinesin-related cut 7 protein associates with mitotic and meiotic spindles in fission yeast

1992 • 262 citations

Monoclonal antibodies to kinesin heavy and light chains stain vesicle-like structures, but not microtubules, in cultured cells.

1989 • 261 citations

Bioenergetics and Kinetics of Microtubule and Actin Filament Assembly–Disassembly

1982 • 242 citations

Mitotic spindle assembly by two different pathways in vitro.

1991 • 235 citations

Mediation of meiotic and early mitotic chromosome segregation in Drosophila by a protein related to kinesin

1990 • 229 citations

Microtubule depolymerization promotes particle and chromosome movement in vitro.

1991 • 215 citations

Kinetochore microtubules in PTK cells.

1992 • 213 citations

A kinesin-like protein required for distributive chromosome segregation in Drosophila

1990 • 209 citations

Microtubule Dynamics and Kinetochore Function in Mitosis

1988 • 208 citations

Two different microtubule-based motor activities with opposite polarities in kinetochores

1991 • 202 citations

The motor for poleward chromosome movement in anaphase is in or near the kinetochore.

1989 • 202 citations

Kinesin heavy chain is essential for viability and neuromuscular functions in Drosophila, but mutants show no defects in mitosis

1991 • 197 citations

Mitosis

1971 • 195 citations

Poleward microtubule flux mitotic spindles assembled in vitro.

1991 • 184 citations

Mitosis : molecules and mechanisms

1989 • 153 citations

Chromosome motion during attachment to the vertebrate spindle: initial saltatory-like behavior of chromosomes and quantitative analysis of force production by nascent kinetochore fibers.

1991 • 149 citations

Microtubule dynamics and chromosome motion visualized in living anaphase cells.

1988 • 147 citations

Functional autonomy of monopolar spindle and evidence for oscillatory movement in mitosis.

1982 • 145 citations

Cloning by Differential Screening of a Xenopus cDNA That Encodes a Kinesin-Related Protein

1991 • 143 citations

Isolation of a sea urchin egg kinesin-related protein using peptide antibodies

1992 • 119 citations

Cloning by differential screening of a Xenopus cDNA that encodes a kinesin-related protein.

1991 • 118 citations

Subcellular localization and sequence of sea urchin kinesin heavy chain: evidence for its association with membranes in the mitotic apparatus and interphase cytoplasm [published erratum appears in J Cell Biol 1991 Aug;114(4):following 863]

1991 • 112 citations

Microtubule-motor activity of a yeast centromere-binding protein complex

1992 • 112 citations

Chemical subdomains within the kinetochore domain of isolated CHO mitotic chromosomes.

1991 • 107 citations

Analysis of the treadmilling model during metaphase of mitosis using fluorescence redistribution after photobleaching.

1986 • 106 citations

Microtubules of the kinetochore fiber turn over in metaphase but not in anaphase.

1989 • 93 citations

Motor proteins for cytoplasmic microtubules

1992 • 87 citations

Stability of microtubule attachment to metaphase kinetochores in PTK1 cells

1990 • 86 citations

Mitotic motors.

1991 • 85 citations

Membranes in the mitotic apparatus

1981 • 62 citations

Cell Division in Diatoms

1991 • 57 citations

Modulation of microtubule stability by kinetochores in vitro.

1990 • 54 citations

Modulation of anaphase spindle microtubule structure in stamen hair cells of Tradescantia by calcium and related agents

1992 • 41 citations

Chromosome fiber dynamics and congression oscillations in metaphase PtK₂ Cells at 23°C

1991 • 40 citations

Microinjection of biotin-tubulin into anaphase cells induces transient elongation of kinetochore microtubules and reversal of chromosome-to-pole motion.

1992 • 37 citations

Biotin-tubulin incorporates into kinetochore fiber microtubules during early but not late anaphase.

1989 • 36 citations

Antiparallel microtubule interactions: Spindle formation and anaphase B

1990 • 33 citations

Cytoplasmic dynein: advances in microtubule-based motility

1991 • 33 citations