Genetic Approaches to Molecular Motors

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

Fluorescent actin filaments move on myosin fixed to a glass surface.

1986 • 839 citations

Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans

1991 • 567 citations

Novel myosin heavy chain encoded by murine dilute coat colour locus

1991 • 534 citations

Force generation of organelle transport measured in vivo by an infrared laser trap

1990 • 520 citations

Acanthamoeba Myosin

1973 • 513 citations

KAR3, a kinesin-related gene required for yeast nuclear fusion

1990 • 504 citations

The Saccharomyces cerevisiae MYO2 gene encodes an essential myosin for vectorial transport of vesicles.

1991 • 471 citations

Gliding movement of and bidirectional transport along single native microtubules from squid axoplasm: evidence for an active role of microtubules in cytoplasmic transport.

1985 • 440 citations

Mutation of a gene that encodes a kinesin-like protein blocks nuclear division in A. nidulans

1990 • 404 citations

Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome

1981 • 391 citations

Actin-dependent organelle movement in squid axoplasm

1992 • 370 citations

Novel potential mitotic motor protein encoded by the fission yeast cut7+ gene

1990 • 366 citations

Kinesin-related proteins required for assembly of the mitotic spindle.

1992 • 347 citations

Fast Axonal Transport in Squid Giant Axon

1982 • 347 citations

Translocation of a localized maternal mRNA to the vegetal pole of Xenopus oocytes

1987 • 346 citations

Fast Axonal Transport in Extruded Axoplasm from Squid Giant Axon

1982 • 333 citations

Myosin I is located at the leading edges of locomoting Dictyostelium amoebae

1989 • 323 citations

Chromosomes move poleward in anaphase along stationary microtubules that coordinately disassemble from their kinetochore ends.

1987 • 314 citations

The Drosophila ninaC locus encodes two photoreceptor cell specific proteins with domains homologous to protein kinases and the myosin heavy chain head

1988 • 306 citations

Suppressor mutations in chlamydomonas reveal a regulatory mechanism for flagellar function

1982 • 300 citations

The regulatory light chain of nonmuscle myosin is encoded by spaghetti-squash, a gene required for cytokinesis in Drosophila

1991 • 281 citations

Paralyzed flagella mutants of Chlamydomonas reinhardtii. Defective for axonemal doublet microtubule arms.

1979 • 275 citations

Myosins of Nonmuscle Cells

1988 • 240 citations

A motile Chlamydomonas flagellar mutant that lacks outer dynein arms.

1985 • 237 citations

Protein structural domains in the Caenorhabditis elegans unc-54 myosin heavy chain gene are not separated by introns.

1983 • 230 citations

Multiple nucleotide-binding sites in the sequence of dynein β heavy chain

1991 • 229 citations

Evidence that the Head of Kinesin Is Sufficient for Force Generation and Motility in Vitro

1990 • 225 citations

The motor for poleward chromosome movement in anaphase is in or near the kinetochore.

1989 • 202 citations

Two different microtubule-based motor activities with opposite polarities in kinetochores

1991 • 202 citations

The yeast MYO1 gene encoding a myosin-like protein required for cell division.

1987 • 199 citations

Excision of the DBA ecotropic provirus in dilute coat-color revertants of mice occurs by homologous recombination involving the viral LTRs

1983 • 191 citations

Structure and molecular weight of the dynein ATPase

1983 • 189 citations

Attachment of transported vesicles to microtubules in axoplasm is facilitated by AMP-PNP

1985 • 184 citations

Quantized velocities at low myosin densities in an in vitro motility

1991 • 182 citations

Four ATP-binding sites in the midregion of the β heavy chain of dynein

1991 • 175 citations

Identification and characterization of a gene encoding a kinesin-like protein in Drosophila

1990 • 172 citations

A mutant of Chlamydomonas reinhardtii that lacks the flagellar outer dynein arm but can swim

1985 • 163 citations

Identification of oda6 as a Chlamydomonas dynein mutant by rescue with the wild-type gene.

1991 • 158 citations

A dynein‐like protein associated with neurotubules

1974 • 154 citations

Myosin IB null mutants of Dictyostelium exhibit abnormalities in motility

1991 • 143 citations

Differential localizations of and requirements for the two Drosophila ninaC kinase/myosins in photoreceptor cells.

1992 • 142 citations

Generation and characterization of Dictyostelium cells deficient in a myosin I heavy chain isoform.

1990 • 137 citations

Evidence that myosin does not contribute to force production in chromosome movement.

1982 • 125 citations

Immunological identification of the genes encoding the four myosin heavy chain isoforms of Caenorhabditis elegans.

1986 • 124 citations

Molecular analysis of the unc-54 myosin heavy-chain gene of Caenorhabditis elegans

1981 • 119 citations

Subcellular localization and sequence of sea urchin kinesin heavy chain: evidence for its association with membranes in the mitotic apparatus and interphase cytoplasm [published erratum appears in J Cell Biol 1991 Aug;114(4):following 863]

1991 • 112 citations

Chemical subdomains within the kinetochore domain of isolated CHO mitotic chromosomes.

1991 • 107 citations

The role of dynein in retrograde axonal transport

1989 • 101 citations

The 110-kD protein-calmodulin complex of the intestinal microvillus (brush border myosin I) is a mechanoenzyme.

1989 • 101 citations

Studies on ATPase activity of sea urchin eggs and the isolated mitotic apparatus

1968 • 90 citations

PATERNAL LOSS (PAL): A MEIOTIC MUTANT IN DROSOPHILA MELANOGASTER CAUSING LOSS OF PATERNAL CHROMOSOMES

1975 • 87 citations

Size selection identifies new genes that regulate Saccharomyces cerevisiae cell proliferation.

1990 • 84 citations

The dictyostelium essential light chain is required for myosin function

1992 • 68 citations

CHROMOSOME BEHAVIOR UNDER THE INFLUENCE OF CLARET-NONDISJUNCTIONAL IN DROSOPHILA MELANOGASTER

1969 • 65 citations

Meiosis and early cleavage in Drosophila melanogaster eggs: Effects of the claret-non-disjunctional mutation

1983 • 64 citations

CYTOLOGIC STUDIES ON THE ABNORMAL DEVELOPMENT OF THE EGGS OF THE CLARET MUTANT TYPE OF DROSOPHILA SIMULANS

1936 • 63 citations

Myosin I heavy-chain genes of Acanthamoeba castellanii: cloning of a second gene and evidence for the existence of a third isoform

1989 • 62 citations

Interacting genes that affect microtubule function: the nc2 allele of the haywire locus fails to complement mutations in the testis-specific beta-tubulin gene of Drosophila.

1988 • 61 citations

The emerging kinesin family of microtubule motor proteins

1991 • 60 citations

Calmodulin‐Binding Proteins and Calcium/Calmodulin Regulated Enzyme Activities Associated with Brain Actomyosin

1990 • 54 citations

The claret locus in Drosophila encodes products required for eyecolor and for meiotic chromosome segregation.

1989 • 50 citations

An internal deletion mutant of a myosin heavy chain in Caenorhabditis elegans.

1977 • 44 citations

Ashen, a new color mutation on chromosome 9 of the mouse

1979 • 17 citations

Axonemal dynein from Tetrahymena

1991 • 7 citations