Prostaglandin E2 Induced Functional Expression of Early Growth Response Factor-1 by EP4, but Not EP2, Prostanoid Receptors via the Phosphatidylinositol 3-Kinase and Extracellular Signal-regulated Kinases

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Prostaglandin E2 Increases Growth and Motility of Colorectal Carcinoma Cells

2001 • 659 citations

Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice

2001 • 585 citations

Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice.

2000 • 504 citations

Lipopolysaccharide Induction of the Tumor Necrosis Factor-α Promoter in Human Monocytic Cells

1997 • 466 citations

Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype.

1994 • 384 citations

Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.

2002 • 372 citations

Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis.

1999 • 363 citations

The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis

2002 • 355 citations

Phosphorylation of Glycogen Synthase Kinase-3 and Stimulation of T-cell Factor Signaling following Activation of EP2 and EP4 Prostanoid Receptors by Prostaglandin E2

2002 • 314 citations

The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis

2002 • 296 citations

Growth Hormone Stimulates Phosphorylation and Activation of Elk-1 and Expression of c-fos, egr-1, and junB through Activation of Extracellular Signal-regulated Kinases 1 and 2

1998 • 256 citations

Pathways of Egr-1-Mediated Gene Transcription in Vascular Biology

1999 • 247 citations

Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype.

1994 • 244 citations

Cyclic AMP-Dependent Kinase Regulates Raf-1 Kinase Mainly by Phosphorylation of Serine 259

2002 • 220 citations

Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist.

1996 • 188 citations

Agonist-dependent Recruitment of Phosphoinositide 3-Kinase to the Membrane by β-Adrenergic Receptor Kinase 1

2001 • 180 citations

Transcriptional Regulation of the Membrane-associated Prostaglandin E2 Synthase Gene

2002 • 148 citations

Identification of prostaglandin E receptor ‘EP2’ cloned from mastocytoma cells as EP4 subtype

1995 • 137 citations

Comparison of Agonist-Induced Internalization of the Human EP2 and EP4 Prostaglandin Receptors: Role of the Carboxyl Terminus in EP4 Receptor Sequestration

2000 • 123 citations

Arachidonic acid increases c-fos and Egr-1 mRNA in 3T3 fibroblasts by formation of prostaglandin E2 and activation of protein kinase C.

1994 • 108 citations

Inhibition of the TNF-pathway: use of infliximab and etanercept as remission-inducing agents in cases of therapy-resistant chronic inflammatory disorders

2002 • 105 citations

Prostanoid receptor heterogeneity through alternative mRNA splicing

1998 • 73 citations

Angiotensin II-induced Transcriptional Activation of the Cyclin D1 Gene Is Mediated by Egr-1 in CHO-AT1A Cells

2001 • 71 citations

FP Prostanoid Receptor Activation of a T-cell Factor/β-Catenin Signaling Pathway

2001 • 63 citations

Phosphorylation of Serine 43 Is Not Required for Inhibition of c-Raf Kinase by the cAMP-dependent Protein Kinase

2000 • 54 citations

Induction of Early Growth Response-1 Gene Expression by Calmodulin Antagonist Trifluoperazine through the Activation of Elk-1 in Human Fibrosarcoma HT1080 Cells

2001 • 38 citations

Agonist‐induced internalization and mitogen‐activated protein kinase activation of the human prostaglandin EP4 receptor

2001 • 38 citations

Cellular Conditioning and Activation of β-Catenin Signaling by the FPB Prostanoid Receptor

2002 • 30 citations

Prostaglandin E2 induces Egr-1 mRNA in MC3T3-E1 osteoblastic cells by a protein kinase C-dependent pathway

1996 • 13 citations