Prostaglandin E2 induces Egr-1 mRNA in MC3T3-E1 osteoblastic cells by a protein kinase C-dependent pathway

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS

1991 • 1,078 citations

Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc.

1987 • 888 citations

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

1988 • 733 citations

Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells.

1994 • 478 citations

The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage

1993 • 384 citations

Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant.

1987 • 360 citations

Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals.

1990 • 343 citations

Transcriptional activation of early‐response genes by hydrogen peroxide in a mouse osteoblastic cell line

1991 • 298 citations

Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN.

1991 • 277 citations

Stimulation of bone resorption by various prostaglandins in organ culture

1975 • 275 citations

A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediate-early transcription factor Egr-1.

1993 • 223 citations

Stimulation of bone formation by prostaglandin E2

1984 • 212 citations

Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1.

1994 • 203 citations

Detection and characterization of cellular EGR-1 binding to its recognition site

1993 • 193 citations

Biphasic Effects of Prostaglandin E₂on Bone Formation in Cultured Fetal Rat Calvariae: Interaction with Cortisol*

1990 • 189 citations

Stimulation of bone resorption by various prostaglandins in organ culture

1975 • 181 citations

Prostaglandins: Mechanisms of action and regulation of production in bone

1993 • 160 citations

5' flanking sequence and genomic structure of Egr-1, a murine mitogen inducible zinc finger encoding gene

1988 • 158 citations

Relationship of cAMP and calcium messenger systems in prostaglandin-stimulated UMR-106 cells.

1988 • 150 citations

Developmental expression of the putative transcription factor Egr-1 suggests that Egr-1 and c-fos are coregulated in some tissues

1990 • 143 citations

Functional significance of an overlapping consensus binding motif for Sp1 and Zif268 in the murine adenosine deaminase gene promoter.

1991 • 132 citations

Role of primary response genes in generating cellular responses to growth factors

1992 • 124 citations

Prostaglandin E₂ stimulates DNA synthesis by a cyclic AMP‐independent pathway in osteoblastic clone MC3T3‐E1 cells

1986 • 118 citations

Egr-1, a serum-inducible zinc finger protein, regulates transcription of the rat cardiac alpha-myosin heavy chain gene

1991 • 118 citations

Regulation of the Egr-1 gene by tumor necrosis factor and interferons in primary human fibroblasts.

1992 • 113 citations

5' upstream sequence and genomic structure of the human primary response gene, EGR-1/TIS8.

1991 • 112 citations

Spontaneous expression of immediately-early response genes c-fos and egr-1 in collagenase-producing rheumatoid synovial fibroblasts

1992 • 110 citations

Arachidonic acid increases c-fos and Egr-1 mRNA in 3T3 fibroblasts by formation of prostaglandin E2 and activation of protein kinase C.

1994 • 108 citations

Promoter elements and transcriptional control of the mouse acetylcholinesterase gene.

1993 • 102 citations

Egr-1 activation of rat adrenal phenylethanolamine N-methyltransferase gene.

1994 • 100 citations

Parathyroid hormone and prostaglandin E2 stimulate both inositol phosphates and cyclic AMP accumulation in mouse osteoblast cultures

1988 • 98 citations

Egr-1 expression in surface Ig-mediated B cell activation. Kinetics and association with protein kinase C activation.

1990 • 82 citations

Retinoic acid increases zif268 early gene expression in rat preosteoblastic cells.

1991 • 79 citations

Protein phosphatase inhibitors induce the sustained expression of the Egr-1 gene and the hyperphosphorylation of its gene product.

1992 • 70 citations

Lipopolysaccharide induces Egr-1 mRNA and protein in murine peritoneal macrophages.

1992 • 67 citations

The Egr transcription factor family: From signal transduction to kidney differentiation

1992 • 66 citations

The effects of prostaglandin E2, parathyroid hormone, and epidermal growth factor on mitogenesis, signaling, and primary response genes in UMR 106-01 osteoblast-like cells.

1992 • 57 citations

Effect of vasoactive agents on induction of Egr-1 in rat mesangial cells: correlation with mitogenicity

1992 • 50 citations

Attenuation of serum inducibility of immediate early genes by oncoproteins in tyrosine kinase signaling pathways.

1993 • 41 citations

Induction of Early Response Genes by Hypergravity in Cultured Mouse Osteoblastic Cells (MC3T3-E1)

1994 • 40 citations

Granulocyte-macrophage colony-stimulating factor induces transcriptional activation of Egr-1 in murine peritoneal macrophages.

1991 • 34 citations

The effects of prostaglandin E2 on DNA and collagen synthesis in osteoblastsIn Vitro

1989 • 33 citations

Transcriptional regulation of the early growth response 1 gene in human myeloid leukemia cells by okadaic acid.

1993 • 31 citations

Autoregulation of prostaglandin E2-induced Ca2+ influx in osteoblast-like cells: Inhibition by self-induced activation of protein kinase C

1992 • 24 citations

Posttranscriptional regulation of the zinc finger-encoding EGR-1 gene by granulocyte-macrophage colony-stimulating factor in human U-937 monocytic leukemia cells: involvement of a pertussis toxin-sensitive G protein.

1991 • 22 citations

The effects of prostaglandin E2, parathyroid hormone, and epidermal growth factor on mitogenesis, signaling, and primary response genes in UMR 106-01 osteoblast-like cells

1992 • 22 citations

The induction of Egr-1 expression by v-Fps is via a protein kinase C-independent intracellular signal that is sequentially dependent upon HaRas and Raf-1.

1992 • 18 citations

Prostaglandin-Induced changes in calcium uptake and cAMP production in osteoblast-like cells: Role of protein kinase C

1991 • 16 citations

Sp1 Interacts with the Consensus Sequence for EGR-1 Gene Product with a Cellular Factor(s) and Activates the Transcription through This Element

1993 • 13 citations