Induction of Early Growth Response-1 Gene Expression by Calmodulin Antagonist Trifluoperazine through the Activation of Elk-1 in Human Fibrosarcoma HT1080 Cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Calmodulin Plays a Pivotal Role in Cellular Regulation

1980 • 2,441 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization

1988 • 1,278 citations

A Nerve Growth Factor-Induced Gene Encodes a Possible Transcriptional Regulatory Factor

1987 • 1,217 citations

Calmodulin—an intracellular calcium receptor

1980 • 964 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin

1998 • 892 citations

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

1988 • 733 citations

Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

1999 • 688 citations

Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element

1992 • 688 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

Early Growth Response Protein 1 (Egr-1): Prototype of a Zinc-finger Family of Transcription Factors

1995 • 593 citations

Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells.

1988 • 580 citations

Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant.

1987 • 360 citations

The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.

1996 • 338 citations

Regulation of the Cell Cycle by Calcium and Calmodulin

1993 • 282 citations

elk , Tissue-Specific ets -Related Genes on Chromosomes X and 14 Near Translocation Breakpoints

1989 • 261 citations

Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET).

1995 • 255 citations

The multifunctional Ca2+/calmodulin-dependent protein kinases

1993 • 251 citations

Decreased Egr-1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation

1997 • 229 citations

Net, a new ets transcription factor that is activated by Ras.

1994 • 216 citations

Early transcriptional events in cell growth

1990 • 192 citations

Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor beta 1.

1996 • 155 citations

Egr-1 negatively regulates human tumor cell growth via the DNA-binding domain.

1995 • 145 citations

Roles of calmodulin-dependent protein kinases and phosphatase in calcium-dependent transcription of immediate early genes.

1994 • 141 citations

Calcium ions and the control of proliferation in normal and cancer cells

1982 • 139 citations

The Calcium/Calmodulin-dependent Protein Phosphatase Calcineurin Is the Major Elk-1 Phosphatase

1997 • 132 citations

Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080.

1984 • 124 citations

Calmodulin: a potential target for cancer chemotherapeutic agents.

1986 • 124 citations

ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development.

1994 • 121 citations

Expression patterns of immediate early transcription factors in human non-small cell lung cancer. The Lung Cancer Study Group.

1995 • 114 citations

5' upstream sequence and genomic structure of the human primary response gene, EGR-1/TIS8.

1991 • 112 citations

The Transcription Factor EGR-1 Suppresses Transformation of Human Fibrosarcoma HT1080 Cells by Coordinated Induction of Transforming Growth Factor-β1, Fibronectin, and Plasminogen Activator Inhibitor-1

1999 • 111 citations

Damage of cellular functions by trifluoperazine, a calmodulin-specific drug

1980 • 111 citations

Activated N-ras controls the transformed phenotype of HT1080 human fibrosarcoma cells

1987 • 109 citations

Stimulation of Elk1 Transcriptional Activity by Mitogen-activated Protein Kinases Is Negatively Regulated by Protein Phosphatase 2B (Calcineurin)

1999 • 105 citations

v-Src activates mitogen-responsive transcription factor Egr-1 via serum response elements

1991 • 97 citations

The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation

1998 • 93 citations

Activation of phospholipase D induced by platelet-derived growth factor is dependent upon the level of phospholipase C-gamma 1.

1994 • 85 citations

Suppression of v-sis-dependent transformation by the transcription factor, Egr-1.

1994 • 75 citations

Cations and calmodulin in normal and neoplastic cell growth regulation

1983 • 74 citations

Calmodulin antagonists of improved potency and specificity for use in the study of calmodulin biochemistry

1988 • 52 citations

Increased content of calmodulin in morris hepatoma 5123 t.c.(h)

1981 • 51 citations

Repression of Platelet-Derived Growth Factor β-Receptor Expression by Mitogenic Growth Factors and Transforming Oncogenes in Murine 3T3 Fibroblasts

1995 • 46 citations

Inhibition of platelet-derived growth factor-mediated signal transduction by transforming ras. Suppression of receptor autophosphorylation.

1991 • 35 citations

Stimulation of the Ca2+-mediated egr-1 and c-fos expression in murine erythroleukaemia cells by cyclosporin A

1998 • 28 citations

Calcium-Dependent Immediate-Early Gene Induction in Lymphocytes Is Negatively Regulated by p21^Ha-ras

1996 • 27 citations

Inhibition of rat brain protein kinase C by lipid soluble psychotropics.

1997 • 22 citations

Antitumor effects of ketoconazole and trifluoperazine in murine T-cell lymphomas

1991 • 19 citations

A role for activated p21 ras in inhibition/regulation of platelet-derived growth factor (PDGF) type-beta receptor activation.

1996 • 11 citations