Mechanisms of microRNA-mediated gene regulation in animal cells

MicroRNAs

2004 • 33,206 citations

The functions of animal microRNAs

2004 • 10,392 citations

Prediction of Mammalian MicroRNA Targets

2003 • 5,070 citations

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

2005 • 4,706 citations

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

2000 • 2,945 citations

The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation

2005 • 2,666 citations

c-Myc-regulated microRNAs modulate E2F1 expression

2005 • 2,371 citations

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

2005 • 2,046 citations

The Diverse Functions of MicroRNAs in Animal Development and Disease

2006 • 2,027 citations

Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1.

2006 • 1,957 citations

Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs

2006 • 1,582 citations

Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi

2001 • 1,492 citations

The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution

2005 • 1,482 citations

Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells

2005 • 1,408 citations

Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs

2004 • 1,406 citations

Translational control of gene expression

2000 • 1,371 citations

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells

2006 • 1,325 citations

Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation

2005 • 1,311 citations

Relief of microRNA-Mediated Translational Repression in Human Cells Subjected to Stress

2006 • 1,285 citations

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

2005 • 1,210 citations

The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis elegans by Blocking LIN-14 Protein Synthesis after the Initiation of Translation

1999 • 1,174 citations

MicroRNAs direct rapid deadenylation of mRNA

2006 • 1,114 citations

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

2002 • 1,081 citations

Repression of protein synthesis by miRNAs: how many mechanisms?

2007 • 1,080 citations

Animal MicroRNAs Confer Robustness to Gene Expression and Have a Significant Impact on 3′UTR Evolution

2005 • 1,079 citations

mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes

2006 • 1,006 citations

Molecular mechanisms of translational control

2004 • 967 citations

P bodies: at the crossroads of post-transcriptional pathways

2006 • 909 citations

Movement of Eukaryotic mRNAs Between Polysomes and Cytoplasmic Processing Bodies

2005 • 754 citations

Short RNAs Repress Translation after Initiation in Mammalian Cells

2006 • 731 citations

A role for the P-body component GW182 in microRNA function

2005 • 670 citations

Fragile X-related protein and VIG associate with the RNA interference machinery

2002 • 646 citations

MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function

2005 • 642 citations

Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies

2005 • 631 citations

General Translational Repression by Activators of mRNA Decapping

2005 • 630 citations

Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway

2004 • 604 citations

A PUF family portrait: 3′UTR regulation as a way of life

2002 • 601 citations

Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

2003 • 574 citations

Identification of Novel Argonaute-Associated Proteins

2005 • 533 citations

Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54

2006 • 505 citations

A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing

2005 • 491 citations

How Do MicroRNAs Regulate Gene Expression?

2007 • 472 citations

A micrococcal nuclease homologue in RNAi effector complexes

2003 • 451 citations

The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTR

2004 • 441 citations

Human let-7a miRNA blocks protein production on actively translating polyribosomes

2006 • 438 citations

Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions

2006 • 434 citations

A human, ATP-independent, RISC assembly machine fueled by pre-miRNA

2005 • 406 citations

Two Genetic Circuits Repress the Caenorhabditis elegans Heterochronic Gene lin-28 after Translation Initiation

2002 • 397 citations

A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies

2005 • 389 citations

The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrn1 in distinct cytoplasmic foci

2002 • 387 citations

Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules

2006 • 385 citations

A Phosphorylated Cytoplasmic Autoantigen, GW182, Associates with a Unique Population of Human mRNAs within Novel Cytoplasmic Speckles

2002 • 365 citations

Evidence that microRNAs are associated with translating messenger RNAs in human cells

2006 • 330 citations

Me31B silences translation of oocyte-localizing RNAs through the formation of cytoplasmic RNP complex duringDrosophilaoogenesis

2001 • 327 citations

Differential Regulation of Germline mRNAs in Soma and Germ Cells by Zebrafish miR-430

2006 • 308 citations

MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development

2007 • 301 citations

The Developmental Timing Regulator AIN-1 Interacts with miRISCs and May Target the Argonaute Protein ALG-1 to Cytoplasmic P Bodies in C. elegans

2005 • 268 citations

Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer

2004 • 216 citations

Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells

2006 • 210 citations

miRNP:mRNA association in polyribosomes in a human neuronal cell line

2004 • 209 citations

Architecture of a Validated MicroRNA::Target Interaction

2004 • 166 citations

Genome-Wide Analysis of mRNAs Regulated by Drosha and Argonaute Proteins in Drosophila melanogaster

2006 • 137 citations