Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome

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1996 • 1,871 citations

Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome

1995 • 908 citations

Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.

1992 • 760 citations

Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome

1994 • 759 citations

The roles of FGFs in the early development of vertebrate limbs

1998 • 659 citations

Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.

1992 • 634 citations

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

1998 • 621 citations

Mendelian Inheritance in Man

1987 • 599 citations

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1999 • 597 citations

[25] Ribbons

1997 • 511 citations

Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia

1996 • 500 citations

Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2

1994 • 466 citations

Identical mutations in the FGFR2 gene cause both Pfeiffer and Crouzon syndrome phenotypes

1995 • 455 citations

Expression cDNA Cloning of the KGF Receptor by Creation of a Transforming Autocrine Loop

1991 • 427 citations

Integration of FGF and TWIST in calvarial bone and suture development

2000 • 402 citations

The Heparan Sulfate–Fibroblast Growth Factor Family: Diversity of Structure and Function

1997 • 400 citations

Developmental expression of two murine fibroblast growth factor receptors, fig and bek

1991 • 397 citations

Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans

1995 • 389 citations

Mendelian Inheritance in Man

2006 • 383 citations

A unique point mutation in the fibroblast growth factor receptor 3 gene (FGFR3) defines a new craniosynostosis syndrome.

1997 • 372 citations

FGFR activation in skeletal disorders: Too much of a good thing

1997 • 319 citations

Characterization of Recombinant Human Fibroblast Growth Factor (FGF)-10 Reveals Functional Similarities with Keratinocyte Growth Factor (FGF-7)

1998 • 307 citations

Fgfr1 and Fgfr2 have distinct differentiation- and proliferation-related roles in the developing mouse skull vault

1999 • 305 citations

Fibroblast-growth-factor receptor mutations in human skeletal disorders

1995 • 300 citations

Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development

2000 • 285 citations

Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal‐epithelial interactions

1995 • 277 citations

Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3.

1992 • 263 citations

Functions of fibroblast growth factors and their receptors

1995 • 254 citations

Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand

1998 • 250 citations

Analysis of phenotypic features and FGFR2 mutations in Apert syndrome.

1995 • 248 citations

De Novo Alu-Element Insertions in FGFR2 Identify a Distinct Pathological Basis for Apert Syndrome

1999 • 244 citations

Structural interactions of fibroblast growth factor receptor with its ligands

2000 • 231 citations

FGF signaling in skeletal development

1998 • 214 citations

Differential effects of FGFR2 mutations on syndactyly and cleft palate in Apert syndrome.

1996 • 209 citations

Fgfr2andosteopontindomains in the developing skull vault are mutually exclusive and can be altered by locally applied FGF2

1997 • 207 citations

The central nervous system in the Apert syndrome

1990 • 202 citations

Fibroblast growth factor receptor 2 mutations in Beare–Stevenson cutis gyrata syndrome

1996 • 181 citations

Comparative three-dimensional analysis of CT-scans of the calvaria and cranial base in Apert and Crouzon syndromes

1993 • 175 citations

Activating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domain

1998 • 168 citations

Heparin Is Required for Cell-Free Binding of Basic Fibroblast Growth Factor to a Soluble Receptor and for Mitogenesis in Whole Cells

1992 • 160 citations

Constitutive receptor activation by Crouzon syndrome mutations in fibroblast growth factor receptor (FGFR)2 and FGFR2/Neu chimeras.

1996 • 144 citations

Ribbons.

1997 • 139 citations

Expression and regulation of basic fibroblast growth factor mRNA levels in mouse osteoblastic MC3T3-E1 cells.

1994 • 126 citations

FGFR2 mutation associated with clinical manifestations consistent with Antley-Bixler syndrome

1998 • 104 citations

Skeletal Growth Factors

2001 • 94 citations

Mapping Ligand Binding Domains in Chimeric Fibroblast Growth Factor Receptor Molecules

1999 • 76 citations

An Updated Pediatric Perspective on the Apert Syndrome

1993 • 73 citations

Regulation of the Fibroblast Growth Factor Receptor 3 Promoter and Intron I Enhancer by Sp1 Family Transcription Factors

1998 • 51 citations

The Role of Bone Centers in the Pathogenesis of Craniosynostosis: An Embryologic Approach Using CT Measurements in Isolated Craniosynostosis and Apert and Crouzon Syndromes

1996 • 46 citations

Is craniofacial morphology in Apert and Crouzon syndromes the same?

1998 • 41 citations

Expression of Fibroblast Growth Factor Receptor-2 Splice Variants is Developmentally and Tissue-Specifically Regulated in the Amphibian Embryo

1994 • 37 citations

The rat osteocalcin fibroblast growth factor (FGF)-responsive element: an okadaic acid-sensitive, FGF-selective transcriptional response motif.

1996 • 34 citations

What Everyone Should Have

1997 • 32 citations

Human Cytogenetics

1993 • 32 citations

The Feet in Apert's Syndrome

1999 • 26 citations

Apert's syndrome with central nervous system anomalies

1979 • 24 citations

The Feet in Apert's Syndrome

1999 • 23 citations

Cognitive functioning of young children with Apert's syndrome.

1997 • 18 citations