The importance of the microenvironment in breast cancer progression: recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

The pathogenesis of cancer metastasis

1980 • 1,750 citations

How does the extracellular matrix direct gene expression?

1982 • 1,475 citations

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

1997 • 1,444 citations

Regulation of development and differentiation by the extracellular matrix

1993 • 1,216 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Normal genetically mosaic mice produced from malignant teratocarcinoma cells.

1975 • 1,175 citations

Diagnostic Histopathology of the Breast

1988 • 1,083 citations

Ackerman's surgical pathology

1974 • 1,070 citations

Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

1992 • 1,047 citations

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

1994 • 1,018 citations

Cadherins in cancer: implications for invasion and metastasis

1993 • 939 citations

Multiple hormone interactions in the developmental biology of the mammary gland.

1980 • 866 citations

Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction

1996 • 772 citations

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor.

1994 • 712 citations

Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane

1989 • 700 citations

Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity.

1991 • 659 citations

Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis.

1993 • 658 citations

Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes

1977 • 641 citations

Pathology of the breast

1992 • 544 citations

Apoptotic cell death and tissue remodelling during mouse mammary gland involution

1992 • 536 citations

Isolation of the NeuHER-2 stimulatory ligand: A 44 kd glycoprotein that induces differentiation of mammary tumor cells

1992 • 534 citations

Breast cancer risk associated with proliferative breast disease and atypical hyperplasia

1993 • 526 citations

Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts.

1992 • 519 citations

Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components.

1995 • 503 citations

Loss of basement membrane components by invasive tumors but not by their benign counterparts.

1983 • 497 citations

Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction.

1994 • 466 citations

Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution.

1992 • 445 citations

Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis

1995 • 429 citations

Cellular Tensegrity: Exploring How Mechanical Changes in the Cytoskeleton Regulate Cell Growth, Migration, and Tissue Pattern during Morphogenesis

1994 • 428 citations

The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells.

1995 • 425 citations

Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene.

1985 • 416 citations

Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression [published erratum appears in J Cell Biol 1996 Feb;132(4):following 752]

1994 • 405 citations

Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma.

1993 • 398 citations

The Mammary gland : development, regulation, and function

1987 • 396 citations

A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression

1995 • 378 citations

Cell shape, cytoskeletal mechanics, and cell cycle control in angiogenesis

1995 • 339 citations

Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle.

1996 • 333 citations

Smooth‐muscle differentiation in stromal cells of malignant and non‐malignant breast tissues

1988 • 319 citations

Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.

1995 • 304 citations

Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland.

1995 • 304 citations

Transfection of human nm23-H1 into the human MDA-MB-435 breast carcinoma cell line: effects on tumor metastatic potential, colonization and enzymatic activity.

1993 • 298 citations

Postnatal Development of the Rodent Mammary Gland

1987 • 266 citations

Keratin expression in human mammary epithelial cells cultured from normal and malignant tissue: relation to in vivo phenotypes and influence of medium

1989 • 251 citations

Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast.

1990 • 242 citations

Relation Between Component Parts of Fibrocystic Disease Complex and Breast Cancer<xref ref-type="fn" rid="FN1">2</xref>

1978 • 241 citations

Transient and locally restricted expression of laminin a chain mRNA by developing epithelial cells during kidney organogenesis

1990 • 239 citations

A new diploid nontumorigenic human breast epithelial cell line isolated and propagated in chemically defined medium

1987 • 237 citations

Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells.

1995 • 235 citations

Regulated expression and growth inhibitory effects of transforming growth factor-β isoforms in mouse mammary gland development

1991 • 228 citations

Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation

1994 • 223 citations

Increased content of Type V Collagen in desmoplasia of human breast carcinoma.

1982 • 218 citations

Hemidesmosomes: roles in adhesion, signaling and human diseases

1996 • 213 citations

Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.

1996 • 208 citations

Xenograft Model of Progressive Human Proliferative Breast Disease

1993 • 204 citations

Cellular growth and survival are mediated by β1 integrins in normal human breast epithelium but not in breast carcinoma

1995 • 203 citations

Expression and functional properties of transforming growth factor alpha and epidermal growth factor during mouse mammary gland ductal morphogenesis.

1991 • 196 citations

Integrin alpha subunit ratios, cytoplasmic domains, and growth factor synergy regulate muscle proliferation and differentiation.

1996 • 195 citations

High expression level of alpha 6 integrin in human breast carcinoma is correlated with reduced survival.

1995 • 194 citations

The ?6?1 and ?6?4 integrins in human prostate cancer progression

1995 • 188 citations

The intracellular functions of alpha6beta4 integrin are regulated by EGF.

1996 • 188 citations

Involvement of extracellular matrix constituents in breast cancer

1995 • 188 citations

The turnover of basal lamina glycosaminoglycan correlates with epithelial morphogenesis

1982 • 187 citations

The influence of tissue microenvironment (stroma and extracellular matrix) on the development and function of mammary epithelium.

1993 • 183 citations

Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development.

1994 • 180 citations

Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7.

1995 • 178 citations

Low nm23 protein expression in infiltrating ductal breast carcinomas correlates with reduced patient survival.

1991 • 166 citations

Sustained growth in primary culture of normal mammary epithelial cells embedded in collagen gels

1980 • 165 citations

Alterations in beta-catenin phosphorylation and plakoglobin expression in human breast cancer cells.

1994 • 165 citations

c-erbB-2 Gene Product Associates with Catenins in Human Cancer Cells

1994 • 162 citations

A Novel Function for the nm23-H1 Gene: Overexpression in Human Breast Carcinoma Cells Leads to the Formation of Basement Membrane and Growth Arrest

1994 • 157 citations

Efficient immortalization of luminal epithelial cells from human mammary gland by introduction of simian virus 40 large tumor antigen with a recombinant retrovirus.

1991 • 152 citations

Overexpression of ERBB2 in human mammary epithelial cells signals inhibition of transcription of the E-cadherin gene.

1994 • 146 citations

Foetal and cancer patient fibroblasts produce an autocrine migrationstimulating factor not made by normal adult cells

1988 • 142 citations

Expression of thrombospondin (TSP1) and its receptors (CD36 and CD51) in normal, hyperplastic, and neoplastic human breast.

1993 • 140 citations

A novel regulatory mechanism for whey acidic protein gene expression.

1989 • 137 citations

Regulation of cell surface beta 1 integrin levels during keratinocyte terminal differentiation.

1995 • 134 citations

The development of a functionally relevant cell culture model of progressive human breast cancer

1995 • 133 citations

Expression of E‐cadherin (E‐CD) as related to other prognostic factors and survival in breast cancer

1994 • 132 citations

Low expression of β₁, α₂ and α₃ subunits of VLA integrins in malignant mammary tumours

1991 • 128 citations

Regulatory Mechanisms in Breast Cancer

1991 • 124 citations

Epithelium-dependent extracellular matrix synthesis in transforming growth factor-beta 1-growth-inhibited mouse mammary gland.

1990 • 124 citations

Designer microenvironments for the analysis of cell and tissue function

1990 • 124 citations

Molecular genetic studies of early breast cancer evolution

1994 • 120 citations

The Extracellular Matrix in Epithelial Biology: Shared Molecules and Common Themes in Distant Phyla

1996 • 118 citations

Expression and function of β1 and αvβ3 integrins in ovarian cancer

1996 • 118 citations

Mammary fibroblast influence on normal mouse mammary epithelial cell responses to estrogen in vitro.

1986 • 117 citations

Trisomy 7p and malignant transformation of human breast epithelial cells following epidermal growth factor withdrawal.

1996 • 115 citations

Regulation of mammary morphogenesis: Evidence for extracellular matrix-mediated inhibition of ductal budding by transforming growth factor-β1

1992 • 114 citations

Developmental expression of the syndecans: possible function and regulation

1993 • 112 citations

Changes in expression of α6/β 4 integrin heterodimer in primary and metastatic breast cancer

1992 • 111 citations

Dual origin of mesenchymal tissues participating in mouse mammary gland embryogenesis

1982 • 110 citations

Nonmitogenic Morphoregulatory Action of pp6O^v-src on Multicellular Epithelial Structures

1987 • 110 citations

Teratocarcinomas and Other Neoplasms as Developmental Defects in Gene Expression

1981 • 109 citations

Adhesion systems in normal breast and in invasive breast carcinoma.

1995 • 105 citations

Genetic progression, histological grade, and allelic loss in ductal carcinoma in situ of the breast.

1996 • 105 citations

Transformation of human mammary epithelial cells by oncogenic retroviruses.

1988 • 103 citations

Overcoming obstacles to metastasis ‐ defenses against host defenses: Osteopontin (OPN) as a shield against attack by cytotoxic host cells

1994 • 100 citations

Mammary gland tumor formation in transgenic mice overexpressing stromelysin-1

1995 • 100 citations

Alterations in proteoglycan synthesis common to healing wounds and tumors.

1991 • 98 citations

Invading squamous cell carcinoma can retain a basal lamina. An immunohistochemical study using a monoclonal antibody to type IV collagen.

1984 • 98 citations

Altered integrin expression in adenocarcinoma of the breast. Analysis by in situ hybridization.

1993 • 96 citations

Chromosome abnormalities in benign hyperproliferative disorders of epithelial and stromal breast tissue

1995 • 92 citations

Function of the integrin alpha 6 beta 1 in metastatic breast carcinoma cells assessed by expression of a dominant-negative receptor.

1996 • 91 citations

The embryonic environment strongly attenuates v-src oncogenesis in mesenchymal and epithelial tissues, but not in endothelia.

1990 • 87 citations

Extracellular matrix signaling from the cellular membrane skeleton to the nuclear skeleton: a model of gene regulation.

1996 • 85 citations

Epithelial synthesis of tenascin at tips of growing bronchi and graded accumulation in basement membrane and mesenchyme

1991 • 84 citations

Integrin expression in primary breast cancer and its relation to axillary nodal status

1995 • 81 citations

Human mammary gland morphogenesis in vitro: The growth and differentiation of normal breast epithelium in collagen gel cultures defined by electron microscopy, monoclonal antibodies, and autoradiography

1983 • 80 citations

[25] Cell differentiation by extracellular matrix components

1994 • 79 citations

Alteration of stromal protein and integrin expression in breast—a marker of premalignant change?

1992 • 78 citations

Loss of p53 protein during radiation transformation of primary human mammary epithelial cells.

1994 • 78 citations

Nonmitogenic morphoregulatory action of pp60v-src on multicellular epithelial structures.

1987 • 76 citations

Collagen-induced rapid morphogenesis of human mammary epithelial cells: The role of the α 2 β 1 integrin

1992 • 75 citations

Skin fibroblasts obtained from cancer patients display foetal-like migratory behaviour on collagen gels

1985 • 75 citations

Influence of age and gland topography on cell kinetics of normal human breast tissue.

1987 • 75 citations

Culture systems for study of human mammary epithelial cell proliferation, differentiation and transformation.

1993 • 73 citations

Differential induction of VCAM-1 on human iliac venous and arterial endothelial cells and its role in adhesion.

1993 • 72 citations

Co‐ordinate expression of the alpha‐6 integrin laminin receptor sub‐unit and laminin in breast cancer

1991 • 70 citations

The Basement Membrane and Its Involvement in Carcinoma Cell Invasion

1995 • 69 citations

Breast Development in Puberty

1986 • 67 citations

The Role of Basement Membrane in Angiogenesis and Tumor Growth

1994 • 66 citations

Integrin mediated signal transduction in oncogenesis: An overview

1995 • 65 citations

Calcium-Induced Changes in Distribution and Solubility of Cadherins, Integrins and Their Associated Cytoplasmic Proteins in Human Keratinocytes

1995 • 64 citations

Interaction between erbB- receptors and heregulin in breast cancer tumor progression and drug resistance

1995 • 64 citations

Cell adhesion molecules in the normal and cancerous mammary gland

1996 • 61 citations

Pancreatic morphogenesis and extracellular matrix organization during rat development

1993 • 61 citations

An ultrastructural study of mitosis and cytokinesis in normal ?resting? human breast

1988 • 57 citations

Growth of mouse mammary gland end buds cultured in a collagen gel matrix

1982 • 55 citations

Altered Gene Expression of c-myc, Epidermal Growth Factor Receptor, Transforming Growth Factor-α, and c-erb-B2 in an Immortalized Human Breast Epithelial Cell Line, HMT-3522, Is Associated with Decreased Growth Factor Requirements

1992 • 54 citations

Ligand mediated activation of ectopic EGF receptor promotes matrix protein adhesion and lung colonization of rat mammary adenocarcinoma cells.

1995 • 53 citations

Functional CD4 T cell subset interplay in an intact immune system.

1993 • 53 citations

Cell-ECM interactions in development

1995 • 49 citations

Proliferative breast “disease”. An unresolved diagnostic dilemma

1993 • 45 citations

Alteration of Integrins by Heparin-Binding EGF Like Growth Factor in Human Breast Cancer Cells

1996 • 45 citations

Typhoid vaccine; Vi antigen and Vi antibody.

1957 • 44 citations

Expression of the alpha 6 beta 4 integrin by squamous cell carcinomas and basal cell carcinomas: possible relation to invasive potential?

1994 • 44 citations

Gradual Selection of a Cellular Clone Presenting a Mutation at Codon 179 of the p53 Gene during Establishment of the Immortalized Human Breast Epithelial Cell Line HMT-3522

1994 • 36 citations

Fixed drug eruption caused by tolphenamic acid.

1994 • 36 citations

Preneoplastic transformation of human mammary epithelial cells

1995 • 35 citations

Modulation of growth factor responsiveness of murine mammary carcinoma cells by cell matrix interactions: Correlation of cell proliferation and spreading

1992 • 33 citations

The Cell in Health and Disease

1970 • 33 citations

Stromal-epithelial interactions in normal and neoplastic mammary gland

1991 • 33 citations

The role of cadherin-mediated adhesion in breast cancer

1996 • 32 citations

Increased glycosylation of beta 1 integrins affects the interaction of transformed S115 mammary epithelial cells with laminin-1.

1995 • 31 citations

The Cell in Health and Disease: An Evaluation of Cellular Morphologic Expression of Biologic Behavior

1986 • 29 citations

In vitro karyotype evolution and cytogenetic instability in the non-tumorigenic human breast epithelial cell line HMT-3522

1994 • 29 citations

Characterization of human mammary cell types in primary culture: Immunofluorescent and immunocytochemical indicators of cellular heterogeneity

1989 • 29 citations

Studies of clonal cell lines developed from primary breast cancers indicate that the ability to undergo morphogenesis IN vitro is lost early in malignancy

1992 • 28 citations

Cytogenetic analysis of in vitro karyotype evolution in a cell line established from nonmalignant human mammary epithelium

1989 • 27 citations

Morphological differentiation of hybrids of human mammary epithelial cell lines is dominant and correlates with the pattern of expression of intermediate filaments

1991 • 27 citations

Loss of p53 Protein During Radiation Transformation of Primary Human Mammary Epithelial Cells

1994 • 21 citations

Altered gene expression of c-myc, epidermal growth factor receptor, transforming growth factor-alpha, and c-erb-B2 in an immortalized human breast epithelial cell line, HMT-3522, is associated with decreased growth factor requirements.

1992 • 21 citations

Quantitative Study of Ductal Breast Cancer Progression

1994 • 19 citations

Pathological and biological relevance of cytophotometric DNA content to breast carcinoma genetic progression

1993 • 17 citations

Drosophilachromatin and transcription

1995 • 14 citations

The Microenvironment of the Breast: Three-Dimensional Models to Study the Roles of the Stroma and the Extracellular Matrix in Function and Dysfunction

1995 • 12 citations

EGF enhances attachment of metastatic rat mammary adenocarcinoma cell clone MTLn3 to fibronectin and collagen.

1995 • 10 citations

The cell in health and disease. An evaluation of cellular morphologic expression of biologic behavior. 2nd, revised edition.

1986 • 10 citations

Enhancement of tumor growth by basement membrane: Modulation of growth and angiogenesis by laminin-derived synthetic peptides

1994 • 8 citations

Modulation of integrin-laminin receptor function on mammary tumor cells by prostaglandin E2 receptor antagonism

1994 • 7 citations

Breast Cancer: An Interactive Paradigm

1996 • 5 citations

Induction of Collagen Synthesis in Response to Adhesion and TGFβ is Dependent on the Actin-Containing Cytoskeleton

1994 • 5 citations

Evaluation of proliferating cell types in human and mouse mammary gland by a double immunostaining procedure.

1990 • 4 citations

ALTERATIONS IN INTEGRIN AND BASEMENT-MEMBRANE PROTEIN EXPRESSION BY MALIGNANT BREAST CELLS

1994 • 4 citations

Normal Cell Lineages and the Phenotype of the Breast Cancer Cell

1992 • 3 citations