Redox activation of Ref-1 potentiates cell survival following myocardial ischemia reperfusion injury

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

1994 • 1,512 citations

REPAIR OF OXIDATIVE DAMAGE TO DNA: Enzymology and Biology

1994 • 1,435 citations

Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

2000 • 1,411 citations

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.

1992 • 702 citations

Going APE over ref-1

2000 • 529 citations

Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes.

1991 • 526 citations

Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2

2000 • 515 citations

Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals

1998 • 414 citations

The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains.

1994 • 351 citations

Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein

2000 • 309 citations

Molecular Cloning and Functional Characterization of a New Cap'n' Collar Family Transcription Factor Nrf3

1999 • 290 citations

Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

2001 • 289 citations

Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo

1999 • 241 citations

An essential role of NFκB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia

1998 • 232 citations

Transgene overexpression of αB crystallin confers simultaneous protection against cardiomyocyte apoptosis and necrosis during myocardial ischemia and reperfusion

2001 • 217 citations

Nuclear Import and Export Signals in Control of Nrf2

2005 • 194 citations

Characterization of the DNA-Binding Properties of the Early Growth Response-1 (Egr-1) Transcription Factor: Evidence for Modulation by a Redox Mechanism

1993 • 163 citations

Thioredoxin redox signaling in the ischemic heart: an insight with transgenic mice overexpressing Trx1

2003 • 149 citations

NF‐κB activation prevents apoptotic oxidative stress via an increase of both thioredoxin and MnSOD levels in TNFα‐treated Ewing sarcoma cells

2004 • 124 citations

Hypoxic preconditioning preserves antioxidant reserve in the working rat heart

1995 • 108 citations

Differential regulation of Bcl‐2, AP‐1 and NF‐κB on cardiomyocyte apoptosis during myocardial ischemic stress adaptation

1999 • 105 citations

Angiogenic signal triggered by ischemic stress induces myocardial repair in rat during chronic infarction

2004 • 100 citations

Detection of oxidative stress in heart by estimating the dinitrophenylhydrazine derivative of malonaldehyde

1995 • 86 citations

Activation of the Nitric Oxide Synthase 2 Pathway in the Response of Bone Marrow Stromal Cells to High Doses of Ionizing Radiation

2000 • 77 citations

Use of Quantitative TaqMan Real-Time PCR to Track the Time-Dependent Distribution of Gene Transfer Vectors in Vivo

2000 • 65 citations

Thioredoxin-1 suppresses lung injury and apoptosis induced by diesel exhaust particles (DEP) by scavenging reactive oxygen species and by inhibiting DEP-induced downregulation of Akt

2005 • 64 citations

APE/Ref-1 responses to oxidative stress in aged rats

1998 • 62 citations

Nuclear factor kappaB transactivation is increased but is not involved in the proliferative effects of thioredoxin overexpression in MCF-7 breast cancer cells.

1999 • 60 citations

GATA-4 regulation of myocardial survival in the preconditioned heart

2004 • 53 citations

Local myocardial overexpression of growth hormone attenuates postinfarction remodeling and preserves cardiac function

2004 • 23 citations

Potential candidates for ischemic preconditioning-associated vascular growth pathways revealed by antibody array

2005 • 18 citations

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