Evaluation of caspase activity in apoptotic cells

The biochemistry of apoptosis

2000 • 7,314 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

1999 • 2,796 citations

IAP family proteins---suppressors of apoptosis

1999 • 2,570 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 • 2,054 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

1998 • 1,651 citations

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

2000 • 1,484 citations

Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death

1999 • 1,024 citations

Caspase activation: The induced-proximity model

1999 • 920 citations

Substrate Specificities of Caspase Family Proteases

1997 • 871 citations

Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

2001 • 852 citations

Flow cytometry of apoptotic cell death

2000 • 764 citations

Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process

1999 • 730 citations

Proteases for Cell Suicide: Functions and Regulation of Caspases

2000 • 720 citations

Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.

1995 • 684 citations

Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis

1999 • 639 citations

Caspase-9 and APAF-1 form an active holoenzyme

1999 • 566 citations

Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells

1999 • 518 citations

Using GFP in FRET-based applications

1999 • 482 citations

Caspase-3 Is the Primary Activator of Apoptotic DNA Fragmentation via DNA Fragmentation Factor-45/Inhibitor of Caspase-activated DNase Inactivation

1999 • 482 citations

Caspase Activation Is Required for T Cell Proliferation

1999 • 462 citations

Caspases Are Activated in a Branched Protease Cascade and Control Distinct Downstream Processes in Fas-induced Apoptosis

1998 • 450 citations

The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling

1998 • 419 citations

Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation

1999 • 418 citations

Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes

2001 • 388 citations

Caspase inhibitors

1999 • 372 citations

Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells

1997 • 367 citations

Caspases: their intracellular localization and translocation during apoptosis

1999 • 358 citations

Caspases – controlling intracellular signals by protease zymogen activation

2000 • 329 citations

Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.

1996 • 318 citations

A Role for Caspases in Lens Fiber Differentiation

1998 • 294 citations

Activation of the CED3/ICE-Related Protease CPP32 in Cerebellar Granule Neurons Undergoing Apoptosis But Not Necrosis

1997 • 284 citations

Inactivation of Interleukin-1.beta. Converting Enzyme by Peptide (Acyloxy)methyl Ketones

1994 • 267 citations

Apoptosis in Human Disease: A New Skin for the Old Ceremony?

1999 • 258 citations

Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease.

1998 • 248 citations

Structure of Recombinant Human CPP32 in Complex with the Tetrapeptide Acetyl-Asp-Val-Ala-Asp Fluoromethyl Ketone

1997 • 245 citations

Internucleosomal DNA cleavage triggered by plasma membrane damage during necrotic cell death. Involvement of serine but not cysteine proteases.

1997 • 233 citations

Purification and catalytic properties of human caspase family members

1999 • 231 citations

Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7 Inhibit Apoptosis and Maintain Cell Functionality

2000 • 225 citations

Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis

1997 • 211 citations

Caspase activation in the terminal differentiation of human epidermal keratinocytes

1999 • 196 citations

The proteolytic procaspase activation network: an in vitro analysis

1999 • 195 citations

Assessment of Caspase Activities in Intact Apoptotic Thymocytes Using Cell-Permeable Fluorogenic Caspase Substrates

2000 • 164 citations

Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts

1998 • 120 citations

Sequential and rapid activation of select caspases during apoptosis of normal intestinal epithelial cells

1998 • 119 citations

Activation of caspases triggered by cytochrome c in vitro¹

1998 • 113 citations

Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis

1999 • 108 citations

The most unkindest cut of all: on the multiple roles of mammalian caspases*

2000 • 103 citations

Divinations and Surprises: Genetic Analysis of Caspase Function in Mice

2000 • 101 citations

Protein translocation in apoptosis

1999 • 96 citations

Three-dimensional structures of proteins involved in programmed cell death

1997 • 72 citations

Defective caspase-3 relocalization in non-small cell lung carcinoma

2001 • 71 citations

IL-1 beta-converting enzyme (ICE) is present and functional in human alveolar macrophages: macrophage IL-1 beta release limitation is ICE independent.

1997 • 69 citations

Oncogene-dependent apoptosis in extracts from drug-resistant cells.

1997 • 65 citations

Quantitative analysis of fluorescent caspase substrate cleavage in intact cells and identification of novel inhibitors of apoptosis

2001 • 60 citations

Application of a fluorometric assay to detect caspase activity in thymus tissue undergoing apoptosis in vivo

1999 • 56 citations

Expression of Apoptosis-Controlling Proteins in Acute Leukemia Cells

1999 • 48 citations

Quantification of Active Caspase 3 in Apoptotic Cells

2000 • 46 citations

Fractin immunostaining for the detection of apoptotic cells and apoptotic bodies in formalin-fixed and paraffin-embedded tissue.

1999 • 37 citations

[2] Design of profluorescent protease substrates guided by exciton theory

1997 • 36 citations

Synthesis of a fluorogenic interleukin-1 beta converting enzyme substrate based on resonance energy transfer.

1994 • 33 citations

Determination of Apoptosis and Necrosis

1999 • 21 citations