Oncogene-dependent apoptosis in extracts from drug-resistant cells.

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Apoptosis induced by anticancer drugs

1992 • 861 citations

Cdc25 cell-cycle phosphatase as a target of c-myc

1996 • 691 citations

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

1992 • 665 citations

Induction of the synthesis of a 70,000 dalton mammalian heat shock protein by the adenovirus E1A gene product

1982 • 454 citations

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis.

1993 • 452 citations

Drug-target interactions: only the first step in the commitment to a programmed cell death?

1991 • 412 citations

bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

1997 • 371 citations

Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells

1997 • 367 citations

The cell-death machine

1996 • 351 citations

The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.

1996 • 331 citations

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.

1994 • 310 citations

Ribonucleotide reductase: regulation, regulation, regulation

1992 • 305 citations

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

1994 • 290 citations

Inactivation of Interleukin-1.beta. Converting Enzyme by Peptide (Acyloxy)methyl Ketones

1994 • 267 citations

Oncogenes and cell death

1994 • 266 citations

Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis.

1995 • 243 citations

[43] Interleukin-1β converting enzyme

1994 • 208 citations

Apoptosis by a cytosolic extract from Fas-activated cells.

1995 • 167 citations

Bcl-2 and adenovirus E1B 19 kDA protein prevent E1A-induced processing of CPP32 and cleavage of poly(ADP-ribose) polymerase.

1996 • 144 citations

The human T-cell leukemia virus type I Tax protein induces apoptosis which is blocked by the Bcl-2 protein

1994 • 129 citations

Regulation of Apoptosis by the Transforming Genes of the DNA Tumor Virus Adenovirus

1993 • 89 citations

Nuclear envelope localization of an adenovirus tumor antigen maintains the integrity of cellular DNA.

1984 • 82 citations

Apoptosis: A sticky business

1995 • 57 citations

Apoptotic response to oncogenic stimuli: cooperative and antagonistic interactions between c-myb and the growth suppressor p53.

1996 • 42 citations

Mutational analysis of the transforming and apoptosis suppression activities of the adenovirus E1 B 175R protein

1993 • 34 citations

A common regulation of genes encoding enzymes of the deoxynucleotide metabolism is lost after neoplastic transformation.

1994 • 24 citations