Quantification of Active Caspase 3 in Apoptotic Cells

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Caspases: Enemies Within

1998 • 6,923 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 • 2,054 citations

Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis

1998 • 1,927 citations

Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

1999 • 1,927 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Proteases to die for

1998 • 1,241 citations

Suicidal Tendencies: Apoptotic Cell Death by Caspase Family Proteinases

1999 • 957 citations

Substrate Specificities of Caspase Family Proteases

1997 • 871 citations

Pro-caspase-3 Is a Major Physiologic Target of Caspase-8

1998 • 743 citations

Defects in regulation of apoptosis in caspase-2-deficient mice

1998 • 688 citations

Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE

1998 • 687 citations

Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II

1999 • 631 citations

Caspases and caspase inhibitors

1997 • 573 citations

Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer

1994 • 567 citations

Caspase-9 Can Be Activated without Proteolytic Processing

1999 • 498 citations

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

1996 • 434 citations

Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.

1996 • 371 citations

Properties of the caspases

1998 • 370 citations

Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells

1997 • 367 citations

Inactivation of Interleukin-1.beta. Converting Enzyme by Peptide (Acyloxy)methyl Ketones

1994 • 267 citations

Fas-associated Death Domain Protein Interleukin-1β-converting Enzyme 2 (FLICE2), an ICE/Ced-3 Homologue, Is Proximally Involved in CD95- and p55-mediated Death Signaling

1997 • 256 citations

A combinatorial approach for determining protease specificities: application to interleukin-1β converting enzyme (ICE)

1997 • 255 citations

Structure of Recombinant Human CPP32 in Complex with the Tetrapeptide Acetyl-Asp-Val-Ala-Asp Fluoromethyl Ketone

1997 • 245 citations

Purification and catalytic properties of human caspase family members

1999 • 231 citations

Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis

1997 • 211 citations

Purification of an Interleukin-1β Converting Enzyme-related Cysteine Protease That Cleaves Sterol Regulatory Element-binding Proteins between the Leucine Zipper and Transmembrane Domains

1995 • 135 citations

A cleavage-site-directed inhibitor of interleukin-1β-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes

1996 • 76 citations

IL-1 beta-converting enzyme (ICE) is present and functional in human alveolar macrophages: macrophage IL-1 beta release limitation is ICE independent.

1997 • 69 citations

Oncogene-dependent apoptosis in extracts from drug-resistant cells.

1997 • 65 citations