A Role for Caspases in Lens Fiber Differentiation

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

CELL DEATHS IN NORMAL VERTEBRATE ONTOGENY

1951 • 1,194 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.

1996 • 529 citations

CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis

1996 • 480 citations

The CED-3/ICE-like Protease Mch2 Is Activated during Apoptosis and Cleaves the Death Substrate Lamin A

1996 • 466 citations

Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.

1995 • 407 citations

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.

1994 • 406 citations

Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

1995 • 391 citations

Constitutive expression of the machinery for programmed cell death.

1996 • 386 citations

Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.

1996 • 371 citations

ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B

1996 • 304 citations

Chromatin Degradation in Differentiating Fiber Cells of the Eye Lens

1997 • 187 citations

Expression of a truncated FGF receptor results in defective lens development in transgenic mice

1995 • 176 citations

Control of lens epithelial cell survival.

1993 • 161 citations

An ICE‐like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells

1995 • 158 citations

Cleavage of Poly(ADP-ribose) Polymerase by Interleukin-1β Converting Enzyme and Its Homologs TX and Nedd-2

1995 • 155 citations

FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens

1995 • 154 citations

Programmed cell death by default in embryonic cells, fibroblasts, and cancer cells.

1995 • 145 citations

DNA degradation in terminally differentiating lens fiber cells from chick embryos.

1977 • 141 citations

Involvement of multiple proteases during Fas‐mediated apoptosis in T lymphocytes

1995 • 136 citations

Denucleation process of the lens.

1974 • 133 citations

Synthesis of peptide fluoromethyl ketones and the inhibition of human cathepsin B

1985 • 125 citations

Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study

1988 • 121 citations

The Role of Fibroblast Growth Factor in Eye Lens Development^a

1991 • 118 citations

Induction of the Eye Lens

1980 • 111 citations

The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice.

1994 • 104 citations

Terminal lens cell differentiation I. Histological and microspectrophotometric analysis of nuclear Degeneration

1970 • 97 citations

Terminal lens cell differentiation

1969 • 77 citations

Rise and fall of crystallin gene messenger levels during fibroblast growth factor induced terminal differentiation of lens cells

1992 • 73 citations

The physiology of growth

1978 • 59 citations

Nuclear pyknosis during lens fibre differentiation in epithelial explants

1986 • 31 citations

The Retinoblastoma Protein-Binding Region of Simian Virus 40 Large T Antigen Alters Cell Cycle Regulation in Lenses of Transgenic Mice

1994 • 29 citations

BCL-2 ONCOGENE BLOCKS DIFFERENTIATION AND EXTENDS VIABILITY BUT DOES NOT IMMORTALIZE NORMAL HUMAN KERATINOCYTES

1994 • 15 citations