Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Cancer Cell Cycles

1996 • 5,379 citations

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

1997 • 1,466 citations

BRCA1 Mutations in Primary Breast and Ovarian Carcinomas

1994 • 1,205 citations

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

1999 • 1,005 citations

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

1997 • 910 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

1999 • 814 citations

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

1999 • 744 citations

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

1996 • 734 citations

The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse

1996 • 652 citations

Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response

1999 • 621 citations

Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression

1995 • 585 citations

Induction of GADD45 and JNK/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1

1999 • 558 citations

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.

1997 • 537 citations

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

2000 • 533 citations

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiPl

1997 • 509 citations

BRCA1 Required for Transcription-Coupled Repair of Oxidative DNA Damage

1998 • 502 citations

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

2000 • 500 citations

BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected Cells

1999 • 494 citations

BRCA1 physically associates with p53 and stimulates its transcriptional activity

1998 • 484 citations

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

1996 • 468 citations

BRCA1 is a component of the RNA polymerase II holoenzyme

1997 • 450 citations

Evidence for a transcriptional activation function of BRCA1 C-terminal region

1996 • 443 citations

The C-terminal (BRCT) Domains of BRCA1 Interact in Vivo with CtIP, a Protein Implicated in the CtBP Pathway of Transcriptional Repression

1998 • 383 citations

BRCA1 regulates p53-dependent gene expression

1998 • 376 citations

Cooperative tumorigenic effects of germline mutations in Rb and p53

1994 • 374 citations

Growth retardation and tumour inhibition by BRCA1

1996 • 360 citations

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis

2001 • 359 citations

Skin and hair follicle integrity is crucially dependent on β1 integrin expression on keratinocytes

2000 • 350 citations

The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues

1995 • 345 citations

BRCA1 interacts with components of the histone deacetylase complex

1999 • 330 citations

A targeted disruption of the murine Brca1 gene causes γ-irradiation hypersensitivity and genetic instability

1998 • 325 citations

Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.

1996 • 318 citations

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.

1994 • 310 citations

Mutations and Polymorphisms in the familial early-onset breast cancer (BRCA1) gene

1996 • 288 citations

E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis

2002 • 263 citations

BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells

1998 • 237 citations

Localization of BRCA1 and a Splice Variant Identifies the Nuclear Localization Signal

1997 • 233 citations

CBP/p300 interact with and function as transcriptional coactivators of BRCA1

2000 • 225 citations

Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens

2000 • 220 citations

Sequences 5′ of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development

1994 • 208 citations

Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice.

1995 • 200 citations

Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-Δ11b

1997 • 195 citations

BRCA1 is a cell cycle-regulated nuclear phosphoprotein

1997 • 189 citations

Ataxia Telangiectasia Mutated (ATM) Kinase and ATM and Rad3 Related Kinase Mediate Phosphorylation of Brca1 at Distinct and Overlapping Sites

2001 • 186 citations

p53 mutation with frequent novel codons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

1998 • 183 citations

Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53

1998 • 159 citations

E2F1 Has Both Oncogenic and Tumor-Suppressive Properties in a Transgenic Model

1999 • 152 citations

BRCA1-associated growth arrest is RB-dependent

1999 • 147 citations

Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer

2002 • 144 citations

Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

1998 • 138 citations

Tumorigenesis in mice carrying a truncating Brca1 mutation

2001 • 129 citations

Tumour-specific distribution of BRCA1 promoter region methylation supports a pathogenetic role in breast and ovarian cancer

2000 • 123 citations

Incidence of malignant tumours in relatives of BRCA1 and BRCA2 germline mutation carriers

1999 • 121 citations

Regulation of BRCA1 Expression by the Rb-E2F Pathway

2000 • 120 citations

BRCA1 Is Phosphorylated at Serine 1497 In Vivo at a Cyclin-Dependent Kinase 2 Phosphorylation Site

1999 • 115 citations

Impaired DNA Damage Response in Cells Expressing an Exon 11-Deleted Murine Brca1 Variant That Localizes to Nuclear Foci

2001 • 107 citations

Rapid analysis of gene expression (RAGE) facilitates universal expression profiling

1999 • 45 citations

Hereditary breast cancer

1997 • 21 citations

BRCA1 carries tumor suppressor activity distinct from that of p53 and p21

2001 • 18 citations

Sequences 5′ of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a

1994 • 8 citations