Decreased Smad4 expression in the transforming growth factor‐β signaling pathway during progression of esophageal squamous cell carcinoma

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

The Transforming Growth Factor-βs

1991 • 882 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation

2001 • 828 citations

DPC4 gene in various tumor types.

1996 • 680 citations

Smads as transcriptional co-modulators

2000 • 522 citations

Interaction between Wnt and TGF-β signalling pathways during formation of Spemann's organizer

2000 • 467 citations

Tumor suppressor activity of the TGF-β pathway in human cancers

1996 • 412 citations

Positive and negative regulation of TGF-β signaling

2000 • 333 citations

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

1997 • 317 citations

Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis

2000 • 263 citations

Somatic alterations of the DPC4 gene in human colorectal cancers in vivo

1996 • 259 citations

Somatic in vivo alterations of the DPC4 gene at 18q21 in human lung cancers.

1996 • 242 citations

Ligand-dependent Degradation of Smad3 by a Ubiquitin Ligase Complex of ROC1 and Associated Proteins

2001 • 219 citations

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor β signaling by targeting Smads to the ubiquitin–proteasome pathway

2000 • 192 citations

Functions of mammalian Smad genes as revealed by targeted gene disruption in mice

2000 • 174 citations

Genetic events and the role of TGFβ in epithelial tumour progression

1999 • 166 citations

TGF-β and cancer

1999 • 115 citations

Expression of Smad proteins in human colorectal cancer

1999 • 113 citations

ALLELOTYPE OF ADENOMA AND DIFFERENTIATED ADENOCARCINOMA OF THE STOMACH

1996 • 103 citations

Human cyclin D1 oncogene and esophageal squamous cell carcinoma

1995 • 102 citations

Mutation and expression of the metastasis suppressor gene KAI1 in esophageal squamous cell carcinoma

2000 • 86 citations

Increased expression of the P27KIP1 protein in human esophageal cancer cell lines that over-express cyclin D1

1997 • 76 citations

Defective transforming growth factor beta signaling pathway in head and neck squamous cell carcinoma as evidenced by the lack of expression of activated Smad2.

2001 • 63 citations

Smad2 Overexpression Enhances Smad4 Gene Expression and Suppresses CBFA1 Gene Expression in Osteoblastic Osteosarcoma ROS17/2.8 Cells and Primary Rat Calvaria Cells

1998 • 54 citations

Preserved Smad4 expression in the transforming growth factor beta signaling pathway is a favorable prognostic factor in patients with advanced gastric cancer.

2001 • 53 citations

Tumor Suppressing Pathways

1998 • 52 citations

Characterization of theMADH2/Smad2Gene, a HumanMadHomolog Responsible for the Transforming Growth Factor-β and Activin Signal Transduction Pathway

1998 • 52 citations

Proliferative activity of cancer cells in front and center areas of carcinomain situ and invasive sites of esophageal squamous-cell carcinoma

1998 • 47 citations

Gastro-intestinal tumorigenesis in Smad4 mutant mice

2000 • 33 citations

Mutation analysis of transforming growth factor beta type II receptor, Smad2, Smad3 and Smad4 in esophageal squamous cell carcinoma.

2000 • 33 citations

Role of Transforming Growth Factorβin Colorectal Cancer

1993 • 25 citations