Tuning amyloidogenic conformations through cosolvents and hydrostatic pressure: When the soft matter becomes even softer

Protein folding and misfolding

2003 • 4,484 citations

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

2002 • 4,135 citations

Protein aggregation and neurodegenerative disease

2004 • 3,203 citations

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

2002 • 2,424 citations

Casting Metal Nanowires Within Discrete Self-Assembled Peptide Nanotubes

2003 • 2,406 citations

Self-assembling organic nanotubes based on a cyclic peptide architecture

1993 • 1,686 citations

Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding

2001 • 1,228 citations

A possible role for π‐stacking in the self‐assembly of amyloid fibrils

2002 • 1,060 citations

Designing conditions for in vitro formation of amyloid protofilaments and fibrils

1999 • 1,016 citations

Conformational constraints for amyloid fibrillation: the importance of being unfolded

2004 • 1,000 citations

High pressure effects on protein structure and function

1996 • 704 citations

Proteins under pressure

1994 • 682 citations

Protein-solvent preferential interactions, protein hydration, and the modulation of biochemical reactions by solvent components

2002 • 664 citations

Molecular basis for amyloid fibril formation and stability

2005 • 636 citations

Solution Structures of β Peptide and Its Constituent Fragments: Relation to Amyloid Deposition

1991 • 531 citations

The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation

2002 • 515 citations

Propagation of the yeast prion-like [psi+] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor.

1996 • 512 citations

THE COAGULATION OF ALBUMEN BY PRESSURE

1914 • 406 citations

Sonication of proteins causes formation of aggregates that resemble amyloid

2004 • 382 citations

pH-dependent structural transitions of Alzheimer amyloid peptides

1991 • 376 citations

Pressure effects on intra- and intermolecular interactions within proteins

2002 • 341 citations

Emerging Principles of Conformation-Based Prion Inheritance

2003 • 331 citations

Physical, Morphological and Functional Differences between pH 5.8 and 7.4 Aggregates of the Alzheimer's Amyloid Peptide A β

1996 • 329 citations

Emerging ideas on the molecular basis of protein and peptide aggregation

2003 • 316 citations

The effect of macromolecular crowding on protein aggregation and amyloid fibril formation

2004 • 309 citations

Osmolyte-driven contraction of a random coil protein

1998 • 283 citations

Myoglobin forms amyloid fibrils by association of unfolded polypeptide segments

2003 • 273 citations

Amyloidogenic Self-Assembly of Insulin Aggregates Probed by High Resolution Atomic Force Microscopy

2004 • 265 citations

Manipulating the Amyloid-β Aggregation Pathway with Chemical Chaperones

1999 • 264 citations

Conformational Behavior and Aggregation of α-Synuclein in Organic Solvents: Modeling the Effects of Membranes

2003 • 243 citations

The formation of spherulites by amyloid fibrils of bovine insulin

2004 • 233 citations

The “Correctly Folded” State of Proteins: Is It a Metastable State?

2002 • 226 citations

Charge Attraction and β Propensity Are Necessary for Amyloid Fibril Formation from Tetrapeptides

2002 • 219 citations

Insulin at pH 2: Structural Analysis of the Conditions Promoting Insulin Fibre Formation

2002 • 214 citations

Guanidine Hydrochloride Can Induce Amyloid Fibril Formation from Hen Egg-White Lysozyme

2004 • 212 citations

Role of Protein−Water Interactions and Electrostatics in α-Synuclein Fibril Formation

2004 • 200 citations

Interactions Among α-Synuclein, Dopamine, and Biomembranes: Some Clues for Understanding Neurodegeneration in Parkinson's Disease

2004 • 196 citations

The preaggregated state of an amyloidogenic protein: Hydrostatic pressure converts native transthyretin into the amyloidogenic state

2000 • 196 citations

Studies of the Structure of Insulin Fibrils by Fourier Transform Infrared (FTIR) Spectroscopy and Electron Microscopy

2001 • 186 citations

Structure, thermostability, and conformational flexibility of hen egg-white lysozyme dissolved in glycerol

1999 • 185 citations

Aggregation of Bovine Insulin Probed by DSC/PPC Calorimetry and FTIR Spectroscopy

2003 • 174 citations

Stability of proteins: Temperature, pressure and the role of the solvent

2005 • 173 citations

Dissociation of amyloid fibrils of α-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities

2003 • 168 citations

Insulin forms amyloid in a strain‐dependent manner: An FT‐IR spectroscopic study

2004 • 126 citations

Amyloid fibril formation by a helical cytochrome

2001 • 124 citations

Fourier transform infrared spectroscopy in high-pressure studies on proteins

2002 • 113 citations

Ethanol-Perturbed Amyloidogenic Self-Assembly of Insulin: Looking for Origins of Amyloid Strains

2005 • 112 citations

Pressure Effect on the Temperature-Induced Unfolding and Tendency To Aggregate of Myoglobin

1999 • 111 citations

Amyloid-β Protofibrils Differ from Amyloid-β Aggregates Induced in Dilute Hexafluoroisopropanol in Stability and Morphology

2004 • 110 citations

Characterization of the Pressure-induced Intermediate and Unfolded State of Red-shifted Green Fluorescent Protein—A Static and Kinetic FTIR, UV/VIS and Fluorescence Spectroscopy Study

2003 • 107 citations

High Hydrostatic Pressure Dissociates Early Aggregates of TTR105–115, but not the Mature Amyloid Fibrils

2005 • 97 citations

Water-Soluble β-Sheet Models Which Self-Assemble into Fibrillar Structures

1999 • 97 citations

High Pressure Refolding of Recombinant Human Growth Hormone from Insoluble Aggregates

2001 • 94 citations

High Pressure Induces Scrapie-like Prion Protein Misfolding and Amyloid Fibril Formation

2004 • 93 citations

Review: Formation and Properties of Amyloid-like Fibrils Derived from α-Synuclein and Related Proteins

2000 • 92 citations

Solvational Tuning of the Unfolding, Aggregation and Amyloidogenesis of Insulin

2005 • 92 citations

New Insights into the Mechanisms of Protein Misfolding and Aggregation in Amyloidogenic Diseases Derived from Pressure Studies

2004 • 91 citations

Self-Assembly and Gelation of Oxidized Glutathione in Organic Solvents

2001 • 89 citations

Pressure-dissociable reversible assembly of intrinsically denatured lysozyme is a precursor for amyloid fibrils

2004 • 89 citations

Ultra-high-pressure inactivation of prion infectivity in processed meat: A practical method to prevent human infection

2003 • 89 citations

Alternative Prion Structural Changes Revealed by High Pressure

2003 • 88 citations

Autocatalytic Conversion of Recombinant Prion Proteins Displays a Species Barrier

2004 • 86 citations

Partial molar volume, surface area, and hydration changes for equilibrium unfolding and formation of aggregation transition state: High-pressure and cosolute studies on recombinant human IFN-γ

2001 • 84 citations

Formation of amyloid aggregates from human lysozyme and its disease‐associated variants using hydrostatic pressure

2004 • 83 citations

Amyloidogenic domains, prions and structural inheritance: rudiments of early life or recent acquisition?

2004 • 79 citations

The Diastereomeric Assembly of Polylysine Is the Low-Volume Pathway for Preferential Formation of β-Sheet Aggregates

2004 • 76 citations

High Pressure Promotes Circularly Shaped Insulin Amyloid

2004 • 76 citations

Reversible Amyloid Formation by the p53 Tetramerization Domain and a Cancer-associated Mutant

2003 • 76 citations

Chain‐length dependence of α‐helix to β‐sheet transition in polylysine: Model of protein aggregation studied by temperature‐tuned FTIR spectroscopy

2004 • 74 citations

Folding Intermediates of the Prion Protein Stabilized by Hydrostatic Pressure and Low Temperature

2003 • 74 citations

Hydration and Packing are Crucial to Amyloidogenesis as Revealed by Pressure Studies on Transthyretin Variants that Either Protect or Worsen Amyloid Disease

2003 • 72 citations

Equilibrium denaturation of insulin and proinsulin

1990 • 70 citations

Pathological and functional amyloid formation orchestrated by the secretory pathway

2003 • 68 citations

Self-Assembling Peptide Nanotubes from Enantiomeric Pairs of Cyclic Peptides with Alternating <scp>d</scp> and <scp>l</scp> Amino Acid Residues

2004 • 68 citations

Structural Instability and Fibrillar Aggregation of Non-expanded Human Ataxin-3 Revealed under High Pressure and Temperature

2003 • 67 citations

Kinetics and Energetics of Assembly, Nucleation, and Growth of Aggregates and Fibrils for an Amyloidogenic Protein

2002 • 59 citations

The effects of osmotic and hydrostatic pressures on macromolecular systems

2002 • 59 citations

Chemical modification of insulin in amyloid fibrils

2003 • 57 citations

Effect of Aqueous Alcohol Solutions on the Thermal Transition of Lysozyme: A Calorimetric Study

1997 • 57 citations

Amyloid Nucleation and Hierarchical Assembly of Ure2p Fibrils

2004 • 55 citations

Reversible Aggregation Plays a Crucial Role on the Folding Landscape of p53 Core Domain

2004 • 54 citations

Pressure-jump NMR Study of Dissociation and Association of Amyloid Protofibrils

2005 • 52 citations

High‐pressure refolding of bikunin: Efficacy and thermodynamics

2004 • 47 citations

Hydration and structure—the two sides of the insulin aggregation process

2004 • 46 citations

Fourier Transform Infrared Spectroscopic Investigation of Temperature‐ and Pressure‐Induced Disaggregation of Amyloid A

1999 • 45 citations

Reduced proteinase K resistance and infectivity of prions after pressure treatment at 60 °C

2004 • 41 citations

Molecular biology of prions

2002 • 41 citations

Protective effect of lipidic surfaces against pressure-induced conformational changes of poly(L-lysine)

1990 • 40 citations

Pressure Denaturation of the Yeast Prion Protein Ure2

2001 • 39 citations

Template-controlled conformational patterns of insulin fibrillar self-assembly reflect history of solvation of the amyloid nuclei

2005 • 36 citations

Freezing of a Fish Antifreeze Protein Results in Amyloid Fibril Formation

2003 • 35 citations

Equilibrium Intermediates in the Denaturation of Human Insulin and Two Monomeric Insulin Analogs

1994 • 35 citations

Pressure- and temperature-induced unfolding and aggregation of recombinant human interferon-gamma: a Fourier transform infrared spectroscopy study

2003 • 32 citations

Pressure treatment of tailspike aggregates rapidly produces on‐pathway folding intermediates

2003 • 27 citations

Optimized overproduction, purification, characterization and high-pressure sensitivity of the prion protein in the native (PrPC-like) or amyloid (PrPSc-like) conformation

2003 • 25 citations

Protein volume changes on cosolvent denaturation

2004 • 17 citations

Interfacial and Molecular Properties of High-Pressure-Treated β-Lactoglobulin B

2004 • 10 citations

Examination by dynamic light scattering of lysozyme in water/alcohol mixtures

2001 • 8 citations