Amyloid Nucleation and Hierarchical Assembly of Ure2p Fibrils

Prions

1998 • 5,102 citations

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

2002 • 4,135 citations

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

2002 • 2,424 citations

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

Thioflavine T interaction with synthetic Alzheimer's disease β‐amyloid peptides: Detection of amyloid aggregation in solution

1993 • 2,137 citations

Common core structure of amyloid fibrils by synchrotron X-ray diffraction 1 1Edited by F. E. Cohen

1997 • 1,648 citations

Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavine T

1989 • 1,133 citations

Interference by Huntingtin and Atrophin-1 with CBP-Mediated Transcription Leading to Cellular Toxicity

2001 • 1,085 citations

Metal-triggered Structural Transformations, Aggregation, and Fibrillation of Human α-Synuclein

2001 • 1,043 citations

Self-Seeded Fibers Formed by Sup35, the Protein Determinant of [PSI+], a Heritable Prion-like Factor of S. cerevisiae

1997 • 604 citations

Amyloid fibers are water-filled nanotubes

2002 • 509 citations

Assembly of Aβ Amyloid Protofibrils: An in Vitro Model for a Possible Early Event in Alzheimer's Disease

1999 • 460 citations

An amyloid-forming peptide from the yeast prion Sup35 reveals a dehydrated β-sheet structure for amyloid

2001 • 376 citations

Glutamine Repeats and Neurodegenerative Diseases: Molecular Aspects

2002 • 354 citations

Amyloid-like Features of Polyglutamine Aggregates and Their Assembly Kinetics

2002 • 352 citations

Prion-Inducing Domain of Yeast Ure2p and Protease Resistance of Ure2p in Prion-Containing Cells

1995 • 351 citations

Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity

2001 • 337 citations

Watching amyloid fibrils grow by time-lapse atomic force microscopy 1 1Edited by W. Baumeister

1999 • 327 citations

Is Congo Red an Amyloid-specific Dye?

2001 • 316 citations

A General Model for Amyloid Fibril Assembly Based on Morphological Studies Using Atomic Force Microscopy

2003 • 295 citations

Adsorption of Biological Molecules to a Solid Support for Scanning Probe Microscopy

1997 • 287 citations

Prion Domain Initiation of Amyloid Formation in Vitro from Native Ure2p

1999 • 278 citations

The URE2 gene product of Saccharomyces cerevisiae plays an important role in the cellular response to the nitrogen source and has homology to glutathione s-transferases.

1991 • 276 citations

Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid β-peptide of amyloid plaques

2002 • 220 citations

Mutational analysis of the structural organization of polyglutamine aggregates

2002 • 211 citations

Monitoring the assembly of Ig light-chain amyloid fibrils by atomic force microscopy

1999 • 206 citations

Hierarchical Assembly of β2-Microglobulin Amyloid In Vitro Revealed by Atomic Force Microscopy

2003 • 201 citations

Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats

2001 • 199 citations

The [URE3] prion is an aggregated form of Ure2p that can be cured by overexpression of Ure2p fragments

1999 • 191 citations

Ultrastructural Organization of Amyloid Fibrils byAtomic Force Microscopy

2000 • 188 citations

Mechanisms of amyloidogenesis.

2000 • 169 citations

The prion model for [URE3] of yeast: Spontaneous generation and requirements for propagation

1997 • 163 citations

The nanometer-scale structure of amyloid-Β visualized by atomic force microscopy

1996 • 160 citations

Mechanism of inactivation on prion conversion of the Saccharomyces cerevisiae Ure2 protein

2002 • 159 citations

Hydrophobicity of amino acid subgroups in proteins

1990 • 157 citations

Architecture of Ure2p Prion Filaments

2003 • 144 citations

The yeast prion Ure2p retains its native alpha-helical conformation upon assembly into protein fibrils in vitro

2002 • 143 citations

Structural Characterization of Saccharomyces cerevisiae Prion-like Protein Ure2

1999 • 121 citations

Relationship Between Stability of Folding Intermediates and Amyloid Formation for the Yeast Prion Ure2p: A Quantitative Analysis of the Effects of pH and Buffer System

2003 • 87 citations

Equilibrium folding properties of the yeast prion protein determinant Ure2 1 1Edited by J. Karn

1999 • 82 citations

Stability, Folding, Dimerization, and Assembly Properties of the Yeast Prion Ure2p

2001 • 80 citations

Prion Filament Networks in [Ure3] Cells of Saccharomyces cerevisiae

2001 • 80 citations

Conservation of a portion of the S. cerevisiae Ure2p prion domain that interacts with the full-length protein

2002 • 78 citations

The native-like conformation of Ure2p in fibrils assembled under physiologically relevant conditions switches to an amyloid-like conformation upon heat-treatment of the fibrils

2003 • 72 citations

New method for accurate prediction of solvent accessibility from protein sequence

2000 • 62 citations

The prion domain of yeast Ure2P induces autocatalytic formation of amyloid fibers by a recombinant fusion protein

2000 • 58 citations

Pressure Denaturation of the Yeast Prion Protein Ure2

2001 • 39 citations

Folding of the yeast prion protein Ure2: kinetic evidence for folding and unfolding intermediates 1 1Edited by J. Karn

2002 • 39 citations

The yeast prion [PSI+]: Molecular insights and functional consequences

2001 • 18 citations

Small angle X-ray scattering study of the yeast prion Ure2p

2003 • 8 citations