Cardiac-Specific Overexpression of Tumor Necrosis Factor-α Causes Oxidative Stress and Contractile Dysfunction in Mouse Diaphragm

Applied Multivariate Statistical Analysis.

1988 • 11,858 citations

Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

Dynamic properties of mammalian skeletal muscles.

1972 • 1,886 citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

1986 • 1,591 citations

Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart

1996 • 993 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Pathophysiologically Relevant Concentrations of Tumor Necrosis Factor-α Promote Progressive Left Ventricular Dysfunction and Remodeling in Rats

1998 • 810 citations

Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death.

1996 • 742 citations

Cardiac Failure in Transgenic Mice With Myocardial Expression of Tumor Necrosis Factor-α

1998 • 602 citations

Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock.

1989 • 567 citations

Reactive oxygen in skeletal muscle. I. Intracellular oxidant kinetics and fatigue in vitro

1992 • 496 citations

Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-κB activation in response to tumor necrosis factor α

1998 • 486 citations

Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.

1991 • 479 citations

Effect of hydrogen peroxide and dithiothreitol on contractile function of single skeletal muscle fibres from the mouse

1998 • 438 citations

Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy

1996 • 365 citations

Expression and Functional Significance of Tumor Necrosis Factor Receptors in Human Myocardium

1995 • 348 citations

Left ventricular systolic and diastolic dysfunction after infusion of tumor necrosis factor-alpha in conscious dogs.

1992 • 275 citations

Tumour necrosis factor-α induces superoxide anion generation in mitochondria of L929 cells

1993 • 272 citations

Role of nitric oxide in skeletal muscle: synthesis, distribution and functional importance

1998 • 263 citations

Cytokines modulate glucose transport in skeletal muscle by inducing the expression of inducible nitric oxide synthase

1997 • 178 citations

Cardiac-specific overexpression of tumor necrosis factor-alpha causes lethal myocarditis in transgenic mice

1997 • 161 citations

Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-Alpha in Myocardium in Human Dilated Cardiomyopathy

1997 • 143 citations

Tumor Necrosis Factor-α–Converting Enzyme and Tumor Necrosis Factor-α in Human Dilated Cardiomyopathy

1999 • 127 citations

Cytokine-induced expression of nitric oxide synthase in C2C12 skeletal muscle myocytes

1994 • 111 citations

An overview of tumor necrosis factor α and the failing human heart

1999 • 95 citations

Mitochondria Mediate Tumor Necrosis Factor-α/NF-κB Signaling in Skeletal Muscle Myotubes

1999 • 88 citations

TNF-alpha mRNA expression in diaphragm muscle after endotoxin administration.

1995 • 75 citations

Skeletal muscle abnormalities and evidence for their role in symptom generation in chronic heart failure

1997 • 75 citations

High-dose tumor necrosis factor alpha produces an impairment of hamster diaphragm contractility. Attenuation with a prostaglandin inhibitor.

1996 • 74 citations

Biotin-labeled hairpin oligonucleotides: probes to detect double-strand breaks in DNA in apoptotic cells.

1998 • 72 citations

Changes in voltage activation of contraction in frog skeletal muscle fibres as a result of sarcoplasmic reticulum Ca²⁺‐ATPase activity

1999 • 65 citations

Exogenous reactive oxygen and nitric oxide alter intracellular oxidant status of skeletal muscle fibres

1999 • 59 citations

Peripheral and respiratory muscles in chronic heart failure

1996 • 58 citations

Tumour necrosis factor is expressed in cardiac tissues of patients with heart failure

1996 • 52 citations

Eicosanoids

1993 • 48 citations

Effects Produced by Infusion of a Free Radical-Generating Solution into the Diaphragm

1993 • 40 citations

Biochemistry of exercise X

1999 • 31 citations

Chronic tumour necrosis factor-alpha treatment modifies protein turnover in rat tissues.

1993 • 26 citations

Human recombinant TNFα affects rat diaphragm muscle in vitro

1996 • 18 citations