Eicosanoids

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

Aspirin Selectively Inhibits Prostaglandin Production in Human Platelets

1971 • 1,535 citations

Aspirin, Sulfinpyrazone, or Both in Unstable Angina

1985 • 1,146 citations

Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation

1979 • 928 citations

Release of Prostaglandins and Thromboxane into the Coronary Circulation in Patients with Ischemic Heart Disease

1981 • 597 citations

Role of prostaglandins in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine.

1978 • 454 citations

On the specific vaso‐dilating and plain muscle stimulating substances from accessory genital glands in man and certain animals (prostaglandin and vesiglandin)

1936 • 452 citations

Properties of human seminal plasma

1935 • 361 citations

Antisecretory, antiulcer, cytoprotective and diarrheogenic properties of prostaglandins.

1976 • 330 citations

1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. A common source of platelet-activating factor and arachidonate in human polymorphonuclear leukocytes.

1984 • 296 citations

The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors.

1987 • 295 citations

Inhibition of gastric secretion by prostaglandins

1967 • 285 citations

Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) from 1-alkyl-2-acyl-sn-glycero-3-phosphocholine by rat alveolar macrophages. Phospholipase A2 and acetyltransferase activities during phagocytosis and ionophore stimulation.

1983 • 266 citations

The Complex Pattern of Cytokines in Sepsis Association Between Prostaglandins, Cachectin, and Interleukins

1991 • 254 citations

Enhanced thromboxane A2 and prostacyclin production by cultured rectal mucosa in ulcerative colitis and its inhibition by steroids and sulfasalazine

1981 • 218 citations

Platelet activating factor. Stimulation of the lipoxygenase pathway in polymorphonuclear leukocytes by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine.

1982 • 194 citations

FEMORAL-ARTERY INFUSION OF PROSTAGLANDIN E1 IN SEVERE PERIPHERAL VASCULAR DISEASE

1973 • 172 citations

RELEASE OF VASOACTIVE AMINES FROM RABBIT PLATELETS INDUCED BY SENSITIZED MONONUCLEAR LEUKOCYTES AND ANTIGEN

1970 • 170 citations

The Isolation of Prostaglandin.

1957 • 167 citations

Selective acylation of lyso platelet activating factor by arachidonate in human neutrophils.

1983 • 148 citations

Biosynthesis of platelet-activating factor (PAF-acether) II. Involvement of phospholipase A2 in the formation of PAF-acether and lyso-PAF-acether from rabbit platelets

1982 • 142 citations

Rectal mucosal prostaglandin E2 release and its relation to disease activity, electrical potential difference, and treatment in ulcerative colitis.

1980 • 137 citations

Saturation kinetics applied to in vitro effects of low prostaglandin E2 and F2α concentrations on ion transport across human jejunal mucosa

1980 • 133 citations

Pathogenesis of hypotension in septic shock

1988 • 124 citations

Mediators of Anaphylaxis and Inflammation

1982 • 99 citations

Metabolic fate of platelet-activating factor in neutrophils.

1983 • 97 citations

Prevention of acute aspirin-induced gastric mucosal injury by 15-R-15 methyl prostaglandin E2: An endoscopic study

1984 • 96 citations

Toxicity of tumor necrosis factor is synergistic with gamma-interferon and can be reduced with cyclooxygenase inhibitors.

1987 • 90 citations

PROSTAGLANDINS, NSAIDs, AND CYTOPROTECTION

1992 • 90 citations

The Effect of 16,16-Dimethyl Prostaglandin E2 on Meal-Stimulated Gastric Acid Secretion and Serum Gastrin in Duodenal Ulcer Patients

1976 • 85 citations

Assay of prostaglandin-like substances in faeces and their measurement in ulcerative colitis

1976 • 82 citations

Colonic and small intestinal response to intravenous prostaglandin F2 alpha and E2 in man.

1975 • 81 citations

Effects of Nonsteroidal Anti-inflammatory Drugs on Endogenous Gastrointestinal Prostaglandins and Therapeutic Strategies for Prevention and Treatment of Nonsteroidal Anti-inflammatory Drug—Induced Damage

1992 • 78 citations

The Effects of Tumor Necrosis Factor and Their Selective Inhibition By Ibuprofen

1989 • 69 citations

Thromboxane A2 in acute myocardial infarction

1984 • 67 citations

Platelet activating factor receptor antagonist improves survival and attenuates eicosanoid release in severe endotoxemia.

1990 • 66 citations

Prostacyclin for ischemic ulcers in peripheral arterial disease. A random assignment, placebo controlled study

1985 • 65 citations

Phospholipids and their inhibitors

1992 • 55 citations

Enhanced Platelet Release Reaction, Shortened Platelet Survival Time and Increased Platelet Aggregation and Plasma Thromboxane B2 in Chronic Obstructive Arterial Disease

1985 • 53 citations

Protective effect of enprostil against aspirin-induced gastroduodenal mucosal injury in man

1986 • 45 citations

Prostacyclin for acute coronary insufficiency.

1980 • 45 citations

Cytoprotection by a synthetic prostaglandin against ethanol-induced gastric mucosal damage

1986 • 43 citations

Thromboxane B2, 6-keto-PGF1α, PGE2, PGF2α, and PGA1 plasma levels in arteriosclerosis obliterans: Relationship to clinical manifestations, risk factors, and arterial pathoanatomy

1984 • 41 citations

Systemic phospholipase A2 and cachectin levels in adult respiratory distress syndrome and multiple-organ failure

1992 • 40 citations

Zur kenntnis der pharmakologischen Wirkungen von Natrivsekreten und Extrakten mannlicher accessoricher Geschlechtsdrusen

1934 • 36 citations

Metabolism of platelet-activating factor in isolated perfused rat lung.

1987 • 36 citations

Prostacyclin infusion in patients with acute myocardial infarction.

1985 • 36 citations

Prostaglandins and Thromboxane

1985 • 35 citations

Tumor Necrosis Factor-Induced Mortality Is Reversed with Cyclooxygenase Inhibition

1993 • 32 citations

Prostaglandin E1 infusion in unstable angina: Effects on anginal frequency and cardiac function

1984 • 31 citations

The effects of platelet-activating factor on flow rate and eicosanoid release in the isolated perfused rat gastric vascular bed

1989 • 26 citations

A PAF receptor antagonist, BN 52021, attenuates thromboxane release and improves survival in lethal canine endotoxemia.

1991 • 24 citations

Prostaglandin E1 infusion for small vessel arterial ischaemia.

1983 • 23 citations

Effect of Orally Administered 15(R)-15-Methyl Prostaglandin E2and/or an Anticholinergic Drug on Meal-induced Gastric Acid Secretion and Serum Gastrin Level in Patients with Duodenal Ulcers

1979 • 20 citations

Hypotensive mechanism of acetyl glyceryl ether phosphorylcholine (AGEPC) in dogs. effects on hemodynamics and humoral factors

1985 • 18 citations

E-type prostaglandin binding sites in isolated canine parietal cells: elucidation with (3H) misoprostol free acid.

1987 • 10 citations

Prostaglandin inhibition of acid is cAMP dependent

1987 • 8 citations

Effects of enzymes and protein modifying reagents on the binding of 3H-prostaglandin E2 to porcine oxyntic mucosa

1986 • 4 citations