Platelet-derived Growth Factor Induction of the Immediate-early gene Is Mediated by NF-κB and a 90-kDa Phosphoprotein Coactivator

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS

1991 • 1,078 citations

Identification of two distinct regulatory regions adjacent to the human β-interferon gene

1983 • 1,076 citations

Molecular cloning of gene sequences regulated by platelet-derived growth factor

1983 • 989 citations

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element

1988 • 983 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc.

1987 • 888 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences

1985 • 871 citations

Induction of DNA synthesis in BALB/c 3T3 cells by serum components: Reevaluation of the commitment process

1977 • 695 citations

The High Mobility Group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene

1992 • 632 citations

The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.

1990 • 615 citations

Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells.

1985 • 589 citations

Complexity of the early genetic response to growth factors in mouse fibroblasts.

1988 • 579 citations

Transcriptional Regulation of the Intercellular Adhesion Molecule-1 Gene by Inflammatory Cytokines in Human Endothelial Cells

1995 • 540 citations

NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene.

1994 • 527 citations

NF-κB Subunit-Specific Regulation of the Interleukin-8 Promoter

1993 • 504 citations

Selection of Optimal κB/Rel DNA-Binding Motifs: Interaction of Both Subunits of NF-κB with DNA Is Required for Transcriptional Activation

1992 • 501 citations

Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties.

1988 • 444 citations

Identification and purification of a polypeptide that binds to the c-fos serum response element.

1987 • 398 citations

Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.

1988 • 391 citations

NF-kappa B subunit-specific regulation of the interleukin-8 promoter.

1993 • 369 citations

Inducible binding of a factor to the c-fos enhancer

1986 • 310 citations

Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src

1995 • 309 citations

The SRE: a growth factor responsive transcriptional regulator.

1990 • 287 citations

Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation.

1992 • 286 citations

Regulation of c-myc transcription and mRNA abundance by serum growth factors and cell contact.

1986 • 254 citations

The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP.

1988 • 245 citations

Distinct Protein Targets for Signals Acting at the c- fos Serum Response Element

1991 • 244 citations

Mutation of the c-fos gene dyad symmetry element inhibits serum inducibility of transcription in vivo and the nuclear regulatory factor binding in vitro.

1987 • 238 citations

The Human Homolog of the JE Gene Encodes a Monocyte Secretory Protein

1989 • 227 citations

Differential activation of c-fos promoter elements by serum, lysophosphatidic acid, G proteins and polypeptide growth factors.

1995 • 226 citations

Multiple sequence elements in the c-fos promoter mediate induction by cAMP.

1989 • 225 citations

Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter.

1989 • 220 citations

Functional serum response elements upstream of the growth factor-inducible gene zif268.

1989 • 180 citations

Purification of the c-fos enhancer-binding protein.

1987 • 156 citations

The human homolog of the JE gene encodes a monocyte secretory protein.

1989 • 148 citations

Serum-Inducible Genes

1989 • 143 citations

Identification of the rel Family Members Required for Virus Induction of the Human Beta Interferon Gene

1995 • 142 citations

Two pathways for serum regulation of the c-fos serum response element require specific sequence elements and a minimal domain of serum response factor.

1994 • 142 citations

RelA Is a Potent Transcriptional Activator of the CD28 Response Element within the Interleukin 2 Promoter

1995 • 131 citations

Identification of transcriptional activation and inhibitory domains in serum response factor (SRF) by using GAL4-SRF constructs.

1993 • 120 citations

v-Src activates mitogen-responsive transcription factor Egr-1 via serum response elements

1991 • 97 citations

Cell Cycle Analysis of E2F in Primary Human T Cells Reveals Novel E2F Complexes and Biochemically Distinct Forms of Free E2F

1993 • 94 citations

The serum response factor is extensively modified by phosphorylation following its synthesis in serum-stimulated fibroblasts.

1991 • 92 citations

A novel 7-nucleotide motif located in 3' untranslated sequences of the immediate-early gene set mediates platelet-derived growth factor induction of the JE gene.

1992 • 85 citations

Platelet-derived growth factor-inducible genes respond differentially to at least two distinct intracellular second messengers.

1987 • 84 citations

Induction of the gene encoding mucosal vascular addressin cell adhesion molecule 1 by tumor necrosis factor alpha is mediated by NF-kappa B proteins.

1995 • 74 citations

Glucocorticoids inhibit the transcriptional induction of JE, a platelet-derived growth factor-inducible gene

1991 • 63 citations

Transcriptional regulatory elements downstream of the JunB gene.

1993 • 51 citations

A Cell-Cycle Constraint on the Regulation of Gene Expression by Platelet-Derived Growth Factor

1987 • 44 citations

Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F.

1993 • 42 citations

A New Platelet-Derived Growth Factor-Regulated Genomic Element Which Binds a Serine/Threonine Phosphoprotein Mediates Induction of the Slow Immediate-Early Gene MCP-1

1995 • 39 citations

Evidence for a novel signal transduction pathway activated by platelet-derived growth factor and by double-stranded RNA.

1989 • 30 citations

Mitogenic activation of normal T cells leads to increased initiation of transcription in the c-myc locus.

1988 • 30 citations

Downregulation of JE and KC genes by glucocorticoids does not prevent the G0----G1 transition in BALB/3T3 cells.

1992 • 19 citations

Identification of a Multiprotein Complex Interacting with the c-fos Serum Response Element

1991 • 17 citations

Identification of a multiprotein complex interacting with the c-fos serum response element.

1991 • 7 citations