Role of Nitric Oxide and Its Interaction With Superoxide in the Suppression of Cardiac Muscle Mitochondrial Respiration

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

1981 • 2,777 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

1981 • 1,624 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide

1994 • 1,214 citations

Peroxynitrite formation from macrophage-derived nitric oxide

1992 • 1,118 citations

Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase

1994 • 1,026 citations

Nitric Oxide: Pathophysiological Mechanisms

1995 • 876 citations

Peroxynitrite-mediated oxidation of dihydrorhodamine 123

1994 • 716 citations

Inhibition of Mitochondrial Electron Transport by Peroxynitrite

1994 • 697 citations

Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury.

1988 • 629 citations

The inactivation of Fe-S cluster containing hydro-lyases by superoxide.

1993 • 628 citations

Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide.

1994 • 596 citations

Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.

1994 • 585 citations

Superoxide sensitivity of the Escherichia coli aconitase.

1991 • 499 citations

Effect of Peroxynitrite on the Mitochondrial Respiratory Chain: Differential Susceptibility of Neurones and Astrocytes in Primary Culture

1995 • 493 citations

Superoxide Radical and Iron Modulate Aconitase Activity in Mammalian Cells

1995 • 467 citations

Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.

1986 • 421 citations

Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells.

1982 • 349 citations

Nitric Oxide Potently and Reversibly Deenergizes Mitochondria at Low Oxygen Tension

1994 • 324 citations

Role of nitric oxide in the regulation of oxygen consumption in conscious dogs.

1994 • 320 citations

Role of L-arginine-nitric oxide pathway in myocardial reoxygenation injury

1992 • 312 citations

Nitric Oxide

1995 • 266 citations

Agonist-Induced Peroxynitrite Production from Endothelial Cells

1994 • 254 citations

Role of Endothelium-Derived Nitric Oxide in the Modulation of Canine Myocardial Mitochondrial Respiration In Vitro

1996 • 233 citations

Pharmacological evidence that endothelium-derived relaxing factor is nitric oxide: use of pyrogallol and superoxide dismutase to study endothelium-dependent and nitric oxide-elicited vascular smooth muscle relaxation.

1988 • 229 citations

Inhibition of coronary artery superoxide dismutase attenuates endothelium-dependent and -independent nitrovasodilator relaxation.

1991 • 215 citations

Inhibition of cytochrome c oxidase in turnover by nitric oxide: mechanism and implications for control of respiration

1995 • 207 citations

Spin-trapping evidence that graded myocardial ischemia alters post-ischemic superoxide production

1987 • 205 citations

Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration

1995 • 204 citations

Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme.

1982 • 182 citations

Inhibition of nitric oxide synthesis protects the isolated working rabbit heart from ischaemia-reperfusion injury

1995 • 176 citations

Inhibition of Nitric Oxide Limits Infarct Size in the in Situ Rabbit Heart

1993 • 160 citations

Global ischaemia induces a biphasic response of the mitochondrial respiratory chain. Anoxic pre-perfusion protects against ischaemic damage

1992 • 141 citations

Requirements for neutrophil products and L-arginine in ischemia-reperfusion injury.

1993 • 128 citations

Reoxygenation-dependent decrease in mitochondrial NADH:CoQ reductase (Complex I) activity in the hypoxic/reoxygenated rat heart

1991 • 126 citations

Canine hindlimb blood flow and O2 uptake after inhibition of EDRF/NO synthesis

1994 • 125 citations

The catecholic metal sequestering agent 1,2-dihydroxybenzene-3, 5-disulfonate confers protection against oxidative cell damage

1992 • 109 citations

Development of ischemia-induced damage in defined mitochondrial subpopulations

1985 • 109 citations

Endogenous Peroxynitrite Is Involved in the Inhibition of Mitochondrial Respiration in Immuno-Stimulated J774.2 Macrophages

1995 • 109 citations

Cytochrome c Oxidase Catalysis of the Reduction of Nitric Oxide to Nitrous Oxide

1995 • 72 citations

Role of controlled cardiac reoxygenation in reducing nitric oxide production and cardiac oxidant damage in cyanotic infantile hearts.

1994 • 57 citations

Direct measurement of the accumulation and mitochondrial conversion of nitric oxide within Chinese hamster ovary cells using an intracellular electron paramagnetic resonance technique

1995 • 54 citations

Postischemic oxygen radical production varies with duration of ischemia

1993 • 42 citations

Direct Detrimental Effects ofL-Arginine Upon Ischemia–Reperfusion Injury to Myocardium

1995 • 32 citations