Use of dominant negative nuclear receptors to study xenobiotic-inducible gene expression in primary cultured hepatocytes

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

1995 • 1,626 citations

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 • 1,497 citations

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

1998 • 1,408 citations

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

2001 • 1,271 citations

Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway

1997 • 1,207 citations

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRα

2000 • 965 citations

Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ

1999 • 905 citations

Molecular Determinants of Glucocorticoid Receptor Function and Tissue Sensitivity to Glucocorticoids

1996 • 889 citations

Interpreting cDNA sequences: Some insights from studies on translation

1996 • 785 citations

The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene

1999 • 658 citations

The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation ofCYP3A4by Rifampicin through a Distal Enhancer Module

1999 • 645 citations

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

2000 • 641 citations

Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist

1989 • 599 citations

Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CAR

2000 • 503 citations

Androstane metabolites bind to and deactivate the nuclear receptor CAR-β

1998 • 466 citations

Orphan Nuclear Receptors as eLiXiRs and FiXeRs of Sterol Metabolism

2001 • 356 citations

Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor.

2001 • 355 citations

Pregnane X Receptor (PXR), Constitutive Androstane Receptor (CAR), and Benzoate X Receptor (BXR) Define Three Pharmacologically Distinct Classes of Nuclear Receptors

2002 • 336 citations

Nuclear Receptor Minireview Series

2001 • 308 citations

Identification of the DNA Binding Specificity and Potential Target Genes for the Farnesoid X-activated Receptor

2000 • 268 citations

Differential Transactivation by Two Isoforms of the Orphan Nuclear Hormone Receptor CAR

1997 • 268 citations

Orphan Nuclear Receptors: The Exotics of Xenobiotics

2001 • 216 citations

Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription

1995 • 185 citations

A novel mechanism of action for v-ErbA: Abrogation of the inactivation of transcription factor AP-1 by retinoic acid and thyroid hormone receptors

1991 • 154 citations

Inhibition of peroxisome-proliferator-activated receptor (PPAR)α by MK886

2001 • 151 citations

Pregnane X Receptor (PXR), Constitutive Androstane Receptor (CAR), and Benzoate X Receptor (BXR) Define Three Pharmacologically Distinct Classes of Nuclear Receptors

2002 • 115 citations

Pathologic Human GR Mutant Has a Transdominant Negative Effect on the Wild-Type GR by Inhibiting Its Translocation into the Nucleus: Importance of the Ligand-Binding Domain for Intracellular GR Trafficking

2001 • 97 citations

cAMP-associated Inhibition of Phenobarbital-inducible Cytochrome P450 Gene Expression in Primary Rat Hepatocyte Cultures

1995 • 92 citations

A Novel cis-Acting Element in a Liver Cytochrome P450 3A Gene Confers Synergistic Induction by Glucocorticoids plus Antiglucocorticoids

1995 • 79 citations

Suitability of primary monolayer cultures of adult rat hepatocytes for studies of cholesterol and bile acid metabolism.

1985 • 63 citations

Cholesterol and Bile Acids Regulate Xenosensor Signaling in Drug-mediated Induction of Cytochromes P450

2002 • 62 citations

Differentiated induction of cytochrome P450b/e and P450p mRNAs by dose of phenobarbital in primary cultures of adult rat hepatocytes.

1990 • 61 citations

Regulation of Rat Hepatic Cytochrome P450 Expression by Sterol Biosynthesis Inhibition: Inhibitors of Squalene Synthase Are Potent Inducers of CYP2B Expression in Primary Cultured Rat Hepatocytes and Rat Liver

1998 • 46 citations

Regulation of cytochrome P450 expression by inhibitors of hydroxymethylglutaryl-coenzyme A reductase in primary cultured rat hepatocytes and in rat liver.

1996 • 41 citations

Xenobiotic-enhanced expression of cytochrome P450 2E1 and 2B1/2B2 in primary cultured rat hepatocytes.

1995 • 40 citations

Pathologic Human GR Mutant Has a Transdominant Negative Effect on the Wild-Type GR by Inhibiting Its Translocation into the Nucleus: Importance of the Ligand-Binding Domain for Intracellular GR Trafficking

2001 • 37 citations

Dimerization Interfaces of v-ErbA Homodimers and Heterodimers with Retinoid X Receptor α

2000 • 12 citations

Cited By (0)

Loading...