Regulation of Rat Hepatic Cytochrome P450 Expression by Sterol Biosynthesis Inhibition: Inhibitors of Squalene Synthase Are Potent Inducers of CYP2B Expression in Primary Cultured Rat Hepatocytes and Rat Liver

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 • 1,497 citations

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.

1980 • 1,195 citations

Dealkylation of pentoxyresorufin: A rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat

1985 • 653 citations

Phenobarbital induction of cytochrome P-450 gene expression

1992 • 530 citations

Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid.

1996 • 257 citations

Induction of cytochrome P4501A1: a model for analyzing mammalian gene transcription

1996 • 245 citations

Squalestatin 1, a potent inhibitor of squalene synthase, which lowers serum cholesterol in vivo.

1992 • 207 citations

Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a nonclassical receptor mechanism.

1984 • 182 citations

Improved hybridization assays employing tailed oligonucleotide probes: A direct comparison with 5′-end-labeled oligonucleotide probes and nick-translated plasmid probes

1985 • 161 citations

Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene.

1996 • 159 citations

Peroxisome proliferator-activated receptors: finding the orphan a home

1994 • 157 citations

Localization of a phenobarbital-responsive element (PBRE) in the 5′-flanking region of the rat CYP2B2 gene

1995 • 156 citations

Regulation of cytochrome P-450p by phenobarbital and phenobarbital-like inducers in adult rat hepatocytes in primary monolayer culture and in vivo

1986 • 130 citations

Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo.

1993 • 104 citations

1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity.

1980 • 100 citations

Modulation of xenobiotic-inducible cytochrome P450 gene expression by dexamethasone in primary rat hepatocytes

1995 • 89 citations

Tissue-specific expression of rat mRNAs homologous to cytochromes P-450b and P-450e

1986 • 88 citations

Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes.

1992 • 84 citations

A Novel cis-Acting Element in a Liver Cytochrome P450 3A Gene Confers Synergistic Induction by Glucocorticoids plus Antiglucocorticoids

1995 • 79 citations

Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif.

1996 • 74 citations

Differentiated induction of cytochrome P450b/e and P450p mRNAs by dose of phenobarbital in primary cultures of adult rat hepatocytes.

1990 • 61 citations

Glucocorticoid regulation of a phenobarbital-inducible cytochrome P-450 gene: the presence of a functional glucocorticoid response element in the 5′-flanking region of the CYP2B2 gene

1990 • 54 citations

Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase by 15 alpha-fluorolanost-7-en-3 beta-ol. A mechanism-based inhibitor of cholesterol biosynthesis.

1993 • 51 citations

Inhibition of Mammalian Squalene Synthetase Activity by Zaragozic Acid A Is a Result of Competitive Inhibition Followed by Mechanism-based Irreversible Inactivation

1995 • 49 citations

Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by 24(S),25-oxidolanosterol.

1992 • 41 citations

Regulation of cytochrome P450 expression by inhibitors of hydroxymethylglutaryl-coenzyme A reductase in primary cultured rat hepatocytes and in rat liver.

1996 • 41 citations

Phenobarbital Alters Protein Binding to the CYP2B1/2Phenobarbital-responsive Unit in Native Chromatin

1997 • 38 citations

Divergent effects of cycloheximide on the induction of Class II and Class III cytochrome P450 mRNAs in cultures of adult rat hepatocytes

1990 • 36 citations

Regulation of Phenobarbital-Inducible Cytochrome-P450 2B1/2 mRNA by Lovastatin and Oxysterols in Primary Cultures of Adult Rat Hepatocytes

1993 • 34 citations

Stimulation of HMG-CoA reductase as a consequence of phenobarbital-induced primary stimulation of cholesterol 7 alpha-hydroxylase in rat liver.

1994 • 23 citations

Dose-response relationships for the induction of P450 2B by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in rat and cultured rat hepatocytes

1993 • 20 citations

Rat Liver Cytochrome P450 2B3: Structure of theCYP2B3Gene and Immunological Identification of a Constitutive P450 2B3-Like Protein in Rat Liver

1994 • 20 citations

Modulations in hepatic branch-point enzymes involved in isoprenoid biosynthesis upon dietary and drug treatments of rats

1994 • 19 citations

Promoter region analysis of the rat CYP2B1 and CYP2B2 genes

1996 • 16 citations

Influence of cholesterol and protein diet on liver cytochrome P-450-dependent monooxygenase system in rats

1996 • 15 citations

Absence of enantioselectivity in the pharmacodynamics of P450 2B induction by 5‐ethyl‐5‐phenylhydantoin in the male rat liver or in cultured rat hepatocytes

1994 • 13 citations

REDUCED HEPATIC DRUG-METABOLISING ENZYME ACTIVITIES IN SPONTANEOUSLY HYPERLIPIDAEMIC RAT AS AN ANIMAL MODEL OF HYPERCHOLESTEROLAEMIA

1996 • 12 citations

Negative Regulation by Dexamethasone of Fluvastatin-Inducible CYP2B Expression in Primary Cultures of Rat Hepatocytes: Role of CYP3A

1998 • 12 citations

Plasma cholesterol levels in adult male and female rats after chronic treatment with phenobarbitone.

1984 • 7 citations