Pregnane X Receptor (PXR), Constitutive Androstane Receptor (CAR), and Benzoate X Receptor (BXR) Define Three Pharmacologically Distinct Classes of Nuclear Receptors

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

Solvent-Accessible Surfaces of Proteins and Nucleic Acids

1983 • 2,685 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

1999 • 2,142 citations

P450 GENES: STRUCTURE, EVOLUTION, AND REGULATION

1987 • 1,559 citations

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

1998 • 1,535 citations

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 • 1,497 citations

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

2001 • 1,271 citations

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

2000 • 929 citations

Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin

2001 • 843 citations

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

2001 • 830 citations

Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands

2000 • 805 citations

The Crystal Structure of the Nuclear Receptor for Vitamin D Bound to Its Natural Ligand

2000 • 802 citations

The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity

2001 • 738 citations

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids

2001 • 736 citations

The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene

1998 • 697 citations

The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene

1999 • 658 citations

Humanized xenobiotic response in mice expressing nuclear receptor SXR

2000 • 655 citations

The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation ofCYP3A4by Rifampicin through a Distal Enhancer Module

1999 • 645 citations

The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones

1996 • 638 citations

Phenobarbital-Responsive Nuclear Translocation of the Receptor CAR in Induction of the CYP2B Gene

1999 • 537 citations

Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CAR

2000 • 503 citations

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution

2000 • 487 citations

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements.

1994 • 470 citations

Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor.

2001 • 355 citations

Ligand binding and nuclear receptor evolution

2000 • 288 citations

Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes

2001 • 254 citations

Regulation of theXmyf-5andXmyoDExpression Pattern during Early Xenopus Development

1998 • 211 citations

Binding of Ligands and Activation of Transcription by Nuclear Receptors

2001 • 204 citations

Peptide Mimetic HIV Protease Inhibitors Are Ligands for the Orphan Receptor SXR

2001 • 188 citations

Practical Application of Computer-Aided Drug Design

1997 • 162 citations

CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

2000 • 126 citations

BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites

1998 • 73 citations

Sequential Loss of Two Neighboring Exons of the Tropoelastin Gene During Primate Evolution

1999 • 63 citations

Pattern recognition in the prediction of protein structure. I. Tripeptide conformational probabilities calculated from the amino acid sequence

1989 • 58 citations

Conservation of Signaling Pathways of Xenobiotic-Sensing Orphan Nuclear Receptors, Chicken Xenobiotic Receptor, Constitutive Androstane Receptor, and Pregnane X Receptor, from Birds to Humans

2001 • 51 citations

Molecular Cloning and Functional Characterization of a Novel Nuclear Receptor Similar to an Embryonic Benzoate Receptor BXR

2000 • 15 citations