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Integrins: Versatility, modulation, and signaling in cell adhesion

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Tumor Angiogenesis: Therapeutic Implications

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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

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A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival

2001 • 2,886 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice

1997 • 2,136 citations

Reactive astrocytes: cellular and molecular cues to biological function

1997 • 1,760 citations

Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas

1978 • 1,663 citations

A Matter of Life and Cell Death

1998 • 1,523 citations

Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

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Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Malignant glioma: genetics and biology of a grave matter

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Function and interactions of integrins

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An analysis of dose-effect relationship in the radiotherapy of malignant gliomas

1979 • 850 citations

Chapter 1: Interferons (IFNs)

1986 • 793 citations

Cytoskeleton—Plasma Membrane Interactions

1992 • 792 citations

Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma

1989 • 772 citations

Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase.

1992 • 743 citations

Glioma Invasion in the Central Nervous System

1996 • 574 citations

Primary and secondary glioblastomas: From concept to clinical diagnosis

1999 • 570 citations

Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors

1997 • 526 citations

Adhesion in cell migration

1995 • 520 citations

Cell Type-Specific Expression of Angiopoietin-1 and Angiopoietin-2 Suggests a Role in Glioblastoma Angiogenesis

1998 • 491 citations

Effect of the Extent of Surgical Resection on Survival and Quality of Life in Patients with Supratentorial Glioblastomas and Anaplastic Astrocytomas

1987 • 472 citations

Topographic anatomy and CT correlations in the untreated glioblastoma multiforme

1988 • 450 citations

Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2.

2001 • 401 citations

Microvascular pericytes contain muscle and nonmuscle actins.

1985 • 399 citations

THE FORMS OF GROWTH IN GLIOMAS AND THEIR PRACTICAL SIGNIFICANCE

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Computerized tomographic and pathologic studies of the untreated, quiescent, and recurrent glioblastoma multiforme

1983 • 393 citations

Dichotomy of astrocytoma migration and proliferation

1996 • 389 citations

Patient age, histologic features, and length of survival in patients with glioblastoma multiforme

1987 • 388 citations

REMOVAL OF RIGHT CEREBRAL HEMISPHERE FOR CERTAIN TUMORS WITH HEMIPLEGIA

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Resection, biopsy, and survival in malignant glial neoplasms

1993 • 364 citations

Radiation therapy for neoplasms of the brain

1987 • 363 citations

Integrin signaling revisited

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Mechanisms of Angiogenesis in the Brain

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Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor.

1996 • 350 citations

Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion

1995 • 350 citations

Identification of differentially expressed genes in human gliomas by DNA microarray and tissue chip techniques.

2000 • 329 citations

The extracellular matrix of the central and peripheral nervous systems: structure and function

1988 • 313 citations

Structural Development in Gliomas

1938 • 310 citations

Supratentorial anaplastic gliomas in adults

1989 • 299 citations

Vascular Apoptosis and Involution in Gliomas Precede Neovascularization: A Novel Concept for Glioma Growth and Angiogenesis

2000 • 291 citations

Isolation and characterization of human malignant glioma cells from histologically normal brain

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Supratentorial malignant glioma: Patterns of recurrence and implications for external beam local treatment

1992 • 290 citations

Extracellular-Regulated Kinase Activation and Cas/Crk Coupling Regulate Cell Migration and Suppress Apoptosis during Invasion of the Extracellular Matrix

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The prognostic importance of tumor size in malignant gliomas: a computed tomographic scan study by the Brain Tumor Cooperative Group.

1988 • 273 citations

Metastasizing Neuroectodermal Tumors of the Central Nervous System

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The CNS lesion scar: new vistas on an old regeneration barrier

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Molecular Mechanisms of Developmental and Tumor Angiogenesis

1994 • 241 citations

A randomized comparison of intra-arterial versus intravenous with or without intravenous 5-fluorouracil, for newly diagnosed patients with malignant glioma

1992 • 241 citations

Early Postoperative Magnetic Resonance Imaging after Resection of Malignant Glioma

1994 • 236 citations

Surgical resection and radiation therapy versus biopsy and radiation therapy in the treatment of glioblastoma multiforme

1993 • 236 citations

Integrin Connections Map: To Infinity and Beyond

2002 • 234 citations

Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors.

1994 • 233 citations

In Situ Expression of Angiopoietins in Astrocytomas Identifies Angiopoietin-2 as an Early Marker of Tumor Angiogenesis

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Angiogenesis: A Paradigm for Balanced Extracellular Proteolysis during Cell Migration and Morphogenesis

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Supratentorial Gliomas: Surgical Considerations and Immediate Postoperative Results Gross Total Resection versus Partial Resection

1987 • 205 citations

Determinants of human astrocytoma migration.

1994 • 204 citations

Extent of resection as a prognostic variable in the treatment of gliomas.

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Prognostic implications of the extent of surgical resection in patients with intracranial malignant gliomas

1995 • 190 citations

The Problem of Multicentric Gliomas

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Migration of Human Glioma Cells on Myelin

1996 • 184 citations

Glioma cell motility is associated with reduced transcription of proapoptotic and proliferation genes: a cDNA microarray analysis.

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Gene expression profiling of low-grade diffuse astrocytomas by cDNA arrays.

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Signaling through G Proteins in Platelets: to the Integrins and Beyond

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Spinal subarachnoid metastasis from primary intracranial glioblastoma multiforme

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A mathematical model of glioma growth: the effect of extent of surgical resection

1996 • 169 citations

Brain Stem and Spinal Metastases of Supratentorial Glioblastoma Multiforme: A Clinical Series

1990 • 163 citations

The spread of glioblastoma multiforme as a determining factor in the radiation treated volume

1976 • 162 citations

Astrocytes secrete basal lamina after hemisection of rat spinal cord

1985 • 160 citations

The incidence of multifocal cerebral gliomas. A histologic study of large hemisphere sections

1987 • 153 citations

Prognostic factors for high-grade malignant glioma: Development of a prognostic index

1990 • 152 citations

The Growth of Glioblastoma Multiforme (Astrocytomas, Grades 3 and 4) in Neurosurgical Practice

1961 • 150 citations

Control of human glioma cell growth, migration and invasion in vitro by transforming growth factor β1

1994 • 150 citations

Cytologic composition of the untreated glioblastoma with implications for evaluation of needle biopsies

1989 • 147 citations

Early and Extensive Contribution of Pericytes/Vascular Smooth Muscle Cells to Microvascular Proliferation in Glioblastoma Multiforme

1995 • 145 citations

Dissemination of Supratentorial Malignant Gliomas via the Cerebrospinal Fluid in Children

1992 • 139 citations

Leptomeningeal dissemination of malignant gliomas. Incidence, diagnosis and outcome

1994 • 135 citations

Treatment of malignant glioma: a problem beyond the margins of resection

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Long-Term Survival in Patients with Malignant Astrocytoma

1994 • 129 citations

Survival after stereotactic biopsy of malignant gliomas

1988 • 124 citations

A radioautographic study of a human brain and glioblastoma multiforme after the in vivo uptake of tritiated thymidine

1960 • 124 citations

Postoperative contrast enhancement in patients with brain tumor

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Mechanisms of Glioma Invasion: Role of Matrix-Metalloproteinases

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Overexpression of alpha4 chain-containing laminins in human glial tumors identified by gene microarray analysis.

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Malignant gliomas

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Identification and validation of P311 as a glioblastoma invasion gene using laser capture microdissection.

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Substrates for Astrocytoma Invasion

1995 • 115 citations

The cause of death in patients with glioblastoma is multifactorial:

1991 • 113 citations

Ten-year survival among patients with supratentorial astrocytomas grade III and IV

1988 • 112 citations

Glioblastoma multiforme with extracranial metastases in the absence of previous craniotomy

1970 • 111 citations

Cerebral glioblastoma with cerebrospinal fluid dissemination: a clinicopathological study of 14 cases examined by complete autopsy.

1989 • 106 citations

Development of Extracranial Metastases from a Malignant Astrocytoma in the Absence of Previous Craniotomy

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Head Trauma and Subsequent Brain Tumors

1979 • 104 citations

The Relationship between Survival and the Extent of the Resection in Patients with Supratentorial Malignant Gliomas

1991 • 104 citations

Correlations between cytologic composition and biologic behavior in the glioblastoma multiforme. A postmortem study of 50 cases

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Unlocking the Blood–Brain Barrier: A Role for RMP-7 in Brain Tumor Therapy

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Cerebral Glioblastoma with Cerebrospinal Fluid Dissemination: A Clinicopathological Study of 14 Cases Examined by Complete Autopsy

1989 • 100 citations

Molecular Classification of Human Diffuse Gliomas by Multidimensional Scaling Analysis of Gene Expression Profiles Parallels Morphology‐Based Classification, Correlates with Survival, and Reveals Clinically‐Relevant Novel Glioma Subsets

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Drug streaming during intra-arterial chemotherapy

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Biopsy versus resection for high grade glioma

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Leptomeningeal Metastasis from Supratentorial Malignant Gliomas

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Migratory pattern of fetal rat brain cells and human glioma cells in the adult rat brain.

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Extent of resection in malignant gliomas: a critical summary.

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Age and Radiation Response in Glioblastoma Multiforme

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Immunohistochemical investigation of collagen subtypes in human glioblastomas

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Cerebral Hemispherectomy

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Death-associated protein 3 (Dap-3) is overexpressed in invasive glioblastoma cells in vivo and in glioma cell lines with induced motility phenotype in vitro.

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Large Effect of Age on the Survival of Patients with Glioblastoma Treated with Radiotherapy and Brachytherapy Boost

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Supratentorial Low-Grade Gliomas

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Distribution of Extracellular Matrix Proteins in Primary Human Brain Tumours: An Immunohistochemical Analysis

1987 • 73 citations

Gemistocytic Astrocytes in Gliomas

1975 • 73 citations

Spinal Cord Compression Injury in Guinea Pigs: Structural Changes of Endothelium and Its Perivascular Cell Associations after Blood–Brain Barrier Breakdown and Repair

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Anaplastic human gliomas grown in athymic mice. Morphology and glial fibrillary acidic protein expression.

1981 • 70 citations

Vascular Smooth Muscle Hyperplasia Underlies the Formation of Glomeruloid Vascular Structures of Glioblastoma Multiforme

1992 • 69 citations

Ventricular entry during resection of malignant gliomas: effect on intracranial cerebrospinal fluid tumor dissemination

1994 • 68 citations

Contrasting migratory response of astrocytoma cells to tenascin mediated by different integrins

1996 • 67 citations

CT prognostic criteria of survival after malignant glioma surgery.

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Distribution of Type VI Collagen in Human Gliomas

1987 • 63 citations

REMOVAL OF THE RIGHT CEREBRAL HEMISPHERE FOR INFILTRATING GLIOMA

1933 • 62 citations

Phase II studies of RMP-7 and carboplatin in the treatment of recurrent high grade glioma. RMP-7 European Study Group.

1999 • 60 citations

Proteases and the biology of glioma invasion.

2002 • 60 citations

Changes in Proliferating Cell Nuclear Antigen Expression in Glioblastoma Multiforme Cells along a Stereotactic Biopsy Trajectory

1994 • 58 citations

Growth Factors in Gliomas Revisited

2000 • 56 citations

Glioma cell adhesion and migration on human brain sections.

1998 • 56 citations

Altered Gene Expression in Human Astrocytoma Cells Selected for Migration

1998 • 56 citations

Histamine and prostanoid receptors on glial cells

1994 • 55 citations

Survival in malignant glioma: analysis of prognostic factors with special regard to cytoreductive surgery.

1996 • 53 citations

Thromboxane synthase regulates the migratory phenotype of human glioma cells

1999 • 53 citations

Medulloblastomas with Distant Metastases

1963 • 50 citations

Dissecting glioma invasion: interrelation of adhesion, migration and intercellular contacts determine the invasive phenotype

1999 • 48 citations

Cytological Changes in Cerebrospinal Fluid Associated with Resections of Intracranial Neoplasms

1966 • 47 citations

Cell proliferation and invasion in malignant gliomas.

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Extracranial Metastasis of Cerebral Glioblastoma Multiforme: Case Report

1984 • 44 citations

Diagnostic and pathomorphological aspects of glioma multiplicity

1980 • 44 citations

TP53 gene mutations, nuclear p53 accumulation, expression of Waf/p21, Bcl-2, and CD95 (APO-1/Fas) proteins are not prognostic factors in de novo glioblastoma multiforme.

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Does the extent of surgery have an impact on the survival of patients who receive postoperative radiation therapy for supratentorial low-grade gliomas?

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Basic surgical techniques in the resection of malignant gliomas.

1999 • 40 citations

Gene expression abnormalities in human glial tumors identified by gene array

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The Identification and Characterization of Oligodendrocyte Thromboxane A2 Receptors

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Factors affecting the extension of peritumoural brain oedema. A CT-study

1988 • 33 citations

Thromboxane Synthase Inhibitors Induce Apoptosis in Migration-arrested Glioma Cells

2002 • 28 citations

Gq/11 communicates with thromboxane A2 receptors in human astrocytoma cells, rabbit astrocytes and human platelets.

1995 • 27 citations

The fate of serial heterologously transplanted glioblastoma multiforme in the eye of the guinea pig.

1966 • 22 citations

Dispersion of central nervous system tumors

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Expression of multiple larger-sized transcripts for several genes in oligodendrogliomas: potential markers for glioma subtype

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Surgical treatment of gliomas of the brain.

1955 • 13 citations

Thromboxane Synthase Inhibitors Induce Apoptosis in Migration-arrested Glioma Cells

2002 • 8 citations

Fifty years of neurosurgery argue in favor of glioma resection.

2001 • 8 citations

Migration of human glioma cells in response to tumour cyst fluids

1996 • 8 citations

Cranial nerve function following total cerebral hemispherectomy in the monkey (Macaca rhesus).

1959 • 5 citations

Operative technics and principles utilized in total hemispherectomy in the monkey and the dog.

1959 • 4 citations

Deleted Work

1955 • 0 citations