Systematic Analysis of Repeated Gene Delivery into Animal Lungs with a Recombinant Adenovirus Vector

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

1990 • 1,756 citations

In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

1992 • 953 citations

Adenovirus-Mediated Transfer of a Recombinant α1-Antitrypsin Gene to the Lung Epithelium in Vivo

1991 • 743 citations

An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

1994 • 743 citations

Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis

1993 • 669 citations

Altered Regulation of Airway Epithelial Cell Chloride Channels in Cystic Fibrosis

1986 • 568 citations

Packaging capacity and stability of human adenovirus type 5 vectors

1993 • 457 citations

Adenovirus–mediated in vivo gene transfer and expression in normal rat liver

1992 • 451 citations

Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans

1994 • 373 citations

A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia.

1991 • 348 citations

Adenovirus-Mediated Transfer of the CFTR Gene to Lung of Nonhuman Primates: Toxicity Study

1993 • 324 citations

Cl ^- Channels in CF: Lack of Activation by Protein Kinase C and cAMP-Dependent Protein Kinase

1989 • 267 citations

Safety and efficacy of repetitive adenovirus–mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats

1994 • 216 citations

A differential efficiency of adenovirus-mediated in vivo gene transfer into skeletal muscle cells of different maturity

1994 • 209 citations

Expression of alpha v beta 5 integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway

1995 • 188 citations

Adenovirus-mediated gene transfer for cystic fibrosis: quantitative evaluation of repeated in vivo vector administration to the lung.

1994 • 188 citations

In VivoEvaluation of the Safety of Adenovirus-Mediated Transfer of the Human Cystic Fibrosis Transmembrane Conductance Regulator cDNA to the Lung

1994 • 177 citations

Differential distribution and modulation of expression of alpha 1/beta 1 integrin on human endothelial cells.

1991 • 174 citations

Abnormal localization of cystic fibrosis transmembrane conductance regulator in primary cultures of cystic fibrosis airway epithelia.

1992 • 171 citations

Development and Analysis of Recombinant Adenoviruses for Gene Therapy of Cystic Fibrosis

1993 • 162 citations

Use of Human Adenovirus-based Vectors for Antigen Expression in Animals

1989 • 122 citations

Eight ‘Musts’ for Biotechnology

1988 • 116 citations

Correction of cAMP-Stimulated Fluid Secretion in Cystic Fibrosis Airway Epithelia: Efficiency of Adenovirus-Mediated Gene Transfer In Vitro

1994 • 95 citations

Distribution of the alpha 1-alpha 6 integrin subunits in human developing and term placenta.

1991 • 93 citations

Gene Therapy of Cystic Fibrosis Lung Disease Using E1 Deleted Adenoviruses: A Phase I Trial. University of Michigan, Ann Arbor, Michigan and University of Pennsylvania, Philadelphia, Pennsylvania

1994 • 89 citations

Lung Gene Therapy: In Vivo Adenovirus-Mediated Gene Transfer to Rhesus Monkey Airway Epithelium

1994 • 66 citations

The dual-function hamster receptor for amphotropic murine leukemia virus (MuLV), 10A1 MuLV, and gibbon ape leukemia virus is a phosphate symporter

1995 • 60 citations

Surfactant Protein A-Directed Toxin Gene Kills Lung Cancer Cells In Vitro

1994 • 48 citations

Expression of the Glycoprotein of Vesicular Stomatitis Virus by Infectious Adenovirus Vectors

1989 • 44 citations

Alpha 6 integrin distribution in human embryonic and adult tissues

1994 • 41 citations

Neuroimmune modulation of lymphocyte function—I. Substance P enhances immunoglobulin synthesis in lipopolysaccharide activated murine splenic B cell cultures

1991 • 25 citations