Development and Analysis of Recombinant Adenoviruses for Gene Therapy of Cystic Fibrosis

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS12

1938 • 19,183 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Selective extraction of polyoma DNA from infected mouse cell cultures

1967 • 5,357 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Identification of the Cystic Fibrosis Gene: Genetic Analysis

1989 • 4,105 citations

Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping

1989 • 3,180 citations

A short amino acid sequence able to specify nuclear location

1984 • 2,529 citations

In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

1992 • 953 citations

A simple method of estimating fifty per cent end-points.

1938 • 933 citations

Adenovirus-Mediated Transfer of a Recombinant α1-Antitrypsin Gene to the Lung Epithelium in Vivo

1991 • 743 citations

Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells

1990 • 706 citations

Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel

1991 • 658 citations

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A

1988 • 657 citations

Mechanism of activation of early viral transcription by the adenovirus E1A gene product

1981 • 604 citations

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

1987 • 567 citations

ANIMAL VIRUS DNA REPLICATION

1989 • 520 citations

Cystic fibrosis: a disease in electrolyte transport

1990 • 510 citations

Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis

1992 • 431 citations

Calcium and cAMP activate different chloride channels in the apical membrane of normal and cystic fibrosis epithelia.

1991 • 373 citations

Expression and characterization of the cystic fibrosis transmembrane conductance regulator

1990 • 340 citations

Common Control of the Heat Shock Gene and Early Adenovirus Genes: Evidence for a Cellular E1A-like Activity

1984 • 331 citations

Normal rat cell lines deficient in nuclear thymidine kinase

1981 • 307 citations

Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel.

1991 • 251 citations

Localization of cystic fibrosis transmembrane conductance regulator in chloride secretory epithelia.

1992 • 240 citations

Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport.

1985 • 234 citations

Membrane chloride transport measured using a chloride-sensitive fluorescent probe

1987 • 223 citations

Cystic fibrosis transmembrane conductance regulator: A chloride channel with novel regulation

1992 • 214 citations

Adenovirus type 5 early region 1b gene product is required for efficient shutoff of host protein synthesis

1984 • 186 citations

Cis-acting induction of adenovirus transcription

1983 • 180 citations

Immunization with Live Types 7 and 4 Adenovirus Vaccines. II. Antibody Response and Protective Effect against Acute Respiratory Disease Due to Adenovirus Type 7

1971 • 171 citations

Abnormal localization of cystic fibrosis transmembrane conductance regulator in primary cultures of cystic fibrosis airway epithelia.

1992 • 171 citations

Infection of eucaryotic cells by helper-independent recombinant adenoviruses: early region 1 is not obligatory for integration of viral DNA

1984 • 170 citations

Common control of the heat shock gene and early adenovirus genes: evidence for a cellular E1A-like activity.

1984 • 142 citations

Development of a helper-independent human adenovirus vector and its use in the transfer of the herpes simplex virus thymidine kinase gene

1986 • 113 citations

IMMUNIZATION WITH TYPES 4 AND 7 ADENOVIRUS BY SELECTIVE INFECTION OF THE INTESTINAL TRACT.

1963 • 107 citations

Analysis of human tonsil and cancer DNAs and RNAs for DNA sequences of group C (serotypes 1, 2, 5, and 6) human adenoviruses

1979 • 106 citations

Polypeptide Phosphorylation in Adenovirus-Infected Cells

1977 • 101 citations

Trans-activation of RNA polymerase II and III promoters by SV40 small t antigen

1988 • 98 citations

NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A

1992 • 95 citations

Phosphoproteins of adenovirus 2

1978 • 93 citations

Efficient transformation of human fibroblasts by adenovirus-simian virus 40 recombinants.

1984 • 80 citations

Human cystic fibrosis transmembrane conductance regulator directed to respiratory epithelial cells of transgenic mice

1992 • 78 citations

Molecular mechanisms by which adenoviruses counteract antiviral immune defenses.

1990 • 62 citations

Simple technique for culture of highly differentiated cells from dog tracheal epithelium

1991 • 60 citations

Production of Cystic Fibrosis Transmembrane Conductance Regulator in the Milk of Transgenic Mice

1992 • 57 citations

The carboxy terminus of pp60c-src is a regulatory domain and is involved in complex formation with the middle-T antigen of polyomavirus.

1988 • 50 citations

Construction and Characterization of Viable Deletion Mutants of Simian Virus 40 Lacking Sequences near the 3′ End of the Early Region

1982 • 36 citations

Analysis of human cancer DNA's for DNA sequence of human adenovirus serotypes 3, 7, 11, 14, 16, and 21 in group B1.

1979 • 32 citations

Basolateral membrane potassium conductance is independent of sodium pump activity and membrane voltage in canine tracheal epithelium

1985 • 21 citations

Variable requirements for herpes simplex virus immediate-early proteins in the expression of the adenovirus E2 gene

1990 • 4 citations