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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

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A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

1996 • 1,769 citations

Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription

1990 • 1,343 citations

Methods in Yeast Genetics — A Laboratory Course Manual

1991 • 1,257 citations

Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.

1993 • 795 citations

Characterization of Five Human cDNAs with Homology to the Yeast SIR2 Gene: Sir2-like Proteins (Sirtuins) Metabolize NAD and May Have Protein ADP-Ribosyltransferase Activity

1999 • 781 citations

Exit from Mitosis Is Triggered by Tem1-Dependent Release of the Protein Phosphatase Cdc14 from Nucleolar RENT Complex

1999 • 720 citations

SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast.

1997 • 673 citations

HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription

1996 • 623 citations

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.

1995 • 601 citations

An unusual form of transcriptional silencing in yeast ribosomal DNA.

1997 • 590 citations

Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae.

1994 • 495 citations

The subcellular distribution of terminal N-acetylglucosamine moieties. Localization of a novel protein-saccharide linkage, O-linked GlcNAc.

1986 • 481 citations

An Enzymatic Activity in the Yeast Sir2 Protein that Is Essential for Gene Silencing

1999 • 388 citations

Net1, a Sir2-Associated Nucleolar Protein Required for rDNA Silencing and Nucleolar Integrity

1999 • 383 citations

Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast.

1997 • 376 citations

Efficient Transcriptional Silencing in Saccharomyces cerevisiae Requires a Heterochromatin Histone Acetylation Pattern

1996 • 363 citations

Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae.

1990 • 350 citations

Genetic Analysis of Histone H4: Essential Role of Lysines Subject to Reversible Acetylation

1990 • 346 citations

A Genetic Screen for Ribosomal DNA Silencing Defects Identifies Multiple DNA Replication and Chromatin-Modulating Factors

1999 • 227 citations

Silent information regulator protein complexes in Saccharomyces cerevisiae : A SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3

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Silencing and Heritable Domains of Gene Expression

1995 • 196 citations

Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast.

1995 • 196 citations

Notes: Point Mutations in the Yeast Histone H4 Gene Prevent Silencing of the Silent Mating Type Locus HML

1990 • 168 citations

Distribution of a Limited Sir2 Protein Pool Regulates the Strength of Yeast rDNA Silencing and Is Modulated by Sir4p

1998 • 160 citations

CobB, a New Member of the SIR2 Family of Eucaryotic Regulatory Proteins, Is Required to Compensate for the Lack of Nicotinate Mononucleotide:5,6-Dimethylbenzimidazole Phosphoribosyltransferase Activity in cobT Mutants during Cobalamin Biosynthesis in Salmonella typhimurium LT2

1998 • 146 citations

Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2

1999 • 130 citations

The Conserved Core of a HumanSIR2Homologue Functions in Yeast Silencing

1999 • 93 citations

A useful colony colour phenotype associated with the yeast selectable/counter-selectable marker MET15

1996 • 82 citations

TheSchizosaccharomyces pombe hst4⁺Gene Is aSIR2Homologue with Silencing and Centromeric Functions

1999 • 70 citations

Histone acetylation in baker's yeast. Maintenance of the hyperacetylated configuration in log phase protoplasts.

1982 • 56 citations

Enzymatic measurement of ethanol or NAD in acid extracts of biological samples

1983 • 50 citations

A new paradigm for biochemical energy coupling. Salmonella typhimurium nicotinate phosphoribosyltransferase.

1993 • 43 citations

N-Butyrate incubation of immature chicken erythrocytes preferentially enhances the solubility of β^ chromatin

1985 • 40 citations

Yeast contains multiple forms of histone acetyltransferase

1989 • 29 citations

Properties of the yeast nuclear histone deacetylase

1994 • 22 citations

Expression of human poly(ADP-ribose) polymerase in Saccharomyces cerevisiae

1994 • 17 citations

Cloning of a Leishmania major gene encoding for an antigen with extensive homology to ribosomal protein S3a

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NAD turnover in microplasmodia of physarum polycephalum

1980 • 7 citations