A Novel Role for the Major Histocompatibility Complex Class II Transactivator CIITA in the Repression of IL-4 Production

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function

1997 • 1,326 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 878 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA

1994 • 854 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 828 citations

Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells

1997 • 823 citations

The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

1996 • 677 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene

1997 • 666 citations

Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells.

1983 • 654 citations

REGULATION OF MHC CLASS II GENES: Lessons from a Disease

1996 • 488 citations

Modular structure of a chicken lysozyme silencer: Involvement of an unusual thyroid hormone receptor binding site

1990 • 487 citations

Hyperproliferation and Dysregulation ofIL-4 Expression in NF-ATp-Deficient Mice

1996 • 456 citations

Characterization of antigen receptor response elements within the interleukin-2 enhancer.

1988 • 451 citations

IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice

1990 • 410 citations

Activation of the MHC Class II Transactivator CIITA by Interferon-γ Requires Cooperative Interaction between Stat1 and USF-1

1998 • 358 citations

Mice Lacking the MHC Class II Transactivator (CIITA) Show Tissue-Specific Impairment of MHC Class II Expression

1996 • 356 citations

The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production

1998 • 340 citations

Functions of IL-4 and Control of Its Expression

2017 • 337 citations

Constructing polycompetitor cDNAs for quantitative PCR

1993 • 323 citations

Type 1 and Type 2: a fundamental dichotomy for all T-cell subsets

1996 • 320 citations

Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes.

1994 • 318 citations

Delayed Lymphoid Repopulation with Defects in IL-4–Driven Responses Produced by Inactivation of NF-ATc

1998 • 298 citations

Functions of IL-4 and Control of Its Expression

1997 • 290 citations

Class II transactivator regulates the expression of multiple genes involved in antigen presentation.

1995 • 267 citations

The relationship of IL-4- and IFNγ-producing T cells studied by lineage ablation of IL-4-producing cells

1993 • 265 citations

Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene

1995 • 258 citations

Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter.

1993 • 202 citations

The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer.

1993 • 201 citations

Polarization of IL-4- and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells.

1997 • 188 citations

Activation of class II MHC genes requires both the X ☐ region and the class II transactivator (CIITA)

1995 • 180 citations

Characterization of antigen-specific CD4+ effector T cells in vivo: immunization results in a transient population of MEL-14-, CD45RB- helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4, and interferon gamma.

1991 • 179 citations

Cytokine transcriptional events during helper T cell subset differentiation.

1996 • 174 citations

Human MHC class II gene transcription directed by the car☐yl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency

1995 • 156 citations

Developmental extinction of major histocompatibility complex class II gene expression in plasmocytes is mediated by silencing of the transactivator gene CIITA.

1994 • 155 citations

A common factor regulates both Th1- and Th2-specific cytokine gene expression.

1994 • 151 citations

Molecular analysis of G1B and G3A IFNγ mutants reveals that defects in CIITA or RFX result in defective class II MHC and li gene induction

1994 • 145 citations

Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5

1997 • 140 citations

NF-AT-Driven Interleukin-4 Transcription Potentiated by NIP45

1996 • 136 citations

T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6

1997 • 133 citations

Selective Activation of Th1‐ and Th2‐like Cells in vivo– Response to Human Collagen IV

1991 • 129 citations

The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32

1997 • 129 citations

Mycobacterial and schistosomal antigen-elicited granuloma formation in IFN-gamma and IL-4 knockout mice: analysis of local and regional cytokine and chemokine networks.

1997 • 128 citations

Cytokine responses during mycobacterial and schistosomal antigen-induced pulmonary granuloma formation. Production of Th1 and Th2 cytokines and relative contribution of tumor necrosis factor.

1994 • 128 citations

Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding protein

1997 • 118 citations

Transcription Mediated by NFAT Is Highly Inducible in Effector CD4⁺ T Helper 2 (Th2) Cells but Not in Th1 Cells

1997 • 115 citations

Cytokine function during mycobacterial and schistosomal antigen-induced pulmonary granuloma formation. Local and regional participation of IFN-gamma, IL-10, and TNF.

1995 • 109 citations

Transcription of the interleukin 4 gene is regulated by multiple promoter elements.

1993 • 103 citations

A nuclear factor of activated T cell-like transcription factor in mast cells is involved in IL-5 gene regulation after IgE plus antigen stimulation.

1995 • 99 citations

Importance of acidic, proline/serine/threonine-rich, and GTPbinding regions in the major histocompatibility complex class II transactivator: Generation of transdominant-negative mutants

1997 • 98 citations

Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31

1996 • 90 citations

Nuclear factor-IL6 activates the human IL-4 promoter in T cells.

1995 • 85 citations

A minority subpopulation of CD4+ T cells directs the development of naive CD4+ T cells into IL-4-secreting cells.

1994 • 82 citations

CIITA activates the expression of MHC class II genes in mouse T cells

1995 • 75 citations

CIITA stimulation of transcription factor binding to major histocompatibility complex class II and associated promotersin vivo

1998 • 72 citations

T cell-specific negative regulation of transcription of the human cytokine IL-4.

1992 • 67 citations

HMG I(Y) interferes with the DNA binding of NF-AT factors and the induction of the interleukin 4 promoter in T cells

1996 • 67 citations

The same 50-kDa cellular protein binds to the negative regulatory elements of the interleukin 2 receptor alpha-chain gene and the human immunodeficiency virus type 1 long terminal repeat.

1989 • 67 citations

The role of NF-Y and IRF-2 in the regulation of human IL-4 gene expression.

1994 • 64 citations

A novel enhancer element in the human IL-4 promoter is suppressed by a position-independent silencer.

1993 • 47 citations

Binding and cooperative interactions between two B cell-specific transcriptional coactivators.

1996 • 43 citations

Activation and transdominant suppression of MHC class II and HLA-DMB promoters by a series of C-terminal class II transactivator deletion mutants.

1997 • 31 citations

Viral peptide specific induction of MHC class II expression by murine T cell clones.

1996 • 6 citations

Deleted Work

1955 • 0 citations