Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Ribonucleic acid isolated by cesium chloride centrifugation

1974 • 2,263 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

Cloning of Large Segments of Exogenous DNA into Yeast by Means of Artificial Chromosome Vectors

1987 • 1,517 citations

Gene Splicing by Overlap Extension: Tailor-Made Genes Using the Polymerase Chain Reaction

2013 • 1,306 citations

Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.

1988 • 917 citations

CpG islands as gene markers in the human genome

1992 • 908 citations

Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells

1994 • 888 citations

lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses

1993 • 877 citations

Messenger RNA degradation in eukaryotes

1993 • 858 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function.

1993 • 565 citations

Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.

1986 • 514 citations

Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction.

1993 • 457 citations

IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells.

1995 • 424 citations

Isolation of the Cyclosporin-Sensitive T Cell Transcription Factor NFATp

1993 • 415 citations

Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory.

1991 • 406 citations

Interleukin 13 is a B cell stimulating factor.

1994 • 298 citations

Sequential expression of genes involved in human T lymphocyte growth and differentiation.

1985 • 291 citations

Direct selection: a method for the isolation of cDNAs encoded by large genomic regions.

1991 • 271 citations

Receptor for Interleukin 13

1995 • 266 citations

Cellular and molecular mechanisms for reduced interleukin 4 and interferon-gamma production by neonatal T cells.

1991 • 261 citations

Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc.

1993 • 245 citations

A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes.

1989 • 206 citations

Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells.

1993 • 203 citations

The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer.

1993 • 201 citations

Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter

1993 • 191 citations

Structural comparison and chromosomal localization of the human and mouse IL-13 genes.

1993 • 167 citations

A common factor regulates both Th1- and Th2-specific cytokine gene expression.

1994 • 151 citations

Restricted production of interleukin 4 by activated human T cells.

1988 • 141 citations

Selective loss of a subset of T helper cells in active multiple sclerosis.

1985 • 120 citations

Elevated expression of Th1 cytokines and nitric oxide synthase in the lungs of vaccinated mice after challenge infection with Schistosoma mansoni.

1994 • 115 citations

An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals.

1992 • 83 citations

The interleukin-4-related lymphokines and their binding to hematopoietin receptors.

1992 • 70 citations

The Ca²⁺/calmodulin-activated, phosphoprotein phosphatase calcineurin is sufficient for positive transcriptional regulation of the mouse IL-4 gene

1994 • 62 citations

A Physical Map of 15 Loci on Human Chromosome 5q23-q33 by Two-Color Fluorescence in Situ Hybridization

1993 • 61 citations

Molecular dissection of the mouse interleukin-4 promoter.

1993 • 59 citations

Interleukin 13: novel role in direct regulation of proliferation and differentiation of primitive hematopoietic progenitor cells.

1994 • 56 citations

Construction and characterization of partial digest DNA libraries made from flow-sorted human chromosome 16

1993 • 47 citations

Recent advances in the understanding of the biochemistry and clinical pharmacology of interleukin-2.

1987 • 45 citations

An activation-responsive element in the murine IL-4 gene is the site of an inducible DNA-protein interaction.

1993 • 29 citations

IL-4 and IL-13 induce Lsk, a Csk-like tyrosine kinase, in human monocytes.

1994 • 29 citations