Construction of synthetic signals for glycosyl-phosphatidylinositol anchor attachment. Analysis of amino acid sequence requirements for anchoring.

Glycolipid Anchoring of Plasma Membrane Proteins

1990 • 539 citations

Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement.

1987 • 256 citations

Biosynthesis of Trypanosoma brucei variant surface glycoproteins. N-glycosylation and addition of a phosphatidylinositol membrane anchor.

1986 • 229 citations

Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins.

1988 • 215 citations

Phosphatidylinositol glycan (PI-G) anchored membrane proteins. Amino acid requirements adjacent to the site of cleavage and PI-G attachment in the COOH-terminal signal peptide.

1992 • 211 citations

Signal for Attachment of a Phospholipid Membrane Anchor in Decay Accelerating Factor

1987 • 210 citations

An artificial anchor domain: hydrophobicity suffices to stop transfer

1985 • 206 citations

The mechanism of action of decay-accelerating factor (DAF). DAF inhibits the assembly of C3 convertases by dissociating C2a and Bb.

1987 • 205 citations

Rapid processing of the carboxyl terminus of a trypanosome variant surface glycoprotein.

1985 • 198 citations

A single amino acid in the glycosyl phosphatidylinositol attachment domain determines the membrane topology of FcγRIII

1989 • 189 citations

Expression of membrane interleukin 1 by fibroblasts transfected with murine pro-interleukin 1 alpha cDNA.

1988 • 171 citations

Cloning of random-sequence oligodeoxynucleotides

1986 • 162 citations

Glycophospholipid membrane anchor attachment. Molecular analysis of the cleavage/attachment site.

1991 • 156 citations

Analysis of the signal for attachment of a glycophospholipid membrane anchor.

1989 • 139 citations

Phospholipid-anchored and transmembrane versions of either decay-accelerating factor or membrane cofactor protein show equal efficiency in protection from complement-mediated cell damage.

1991 • 127 citations

COOH-terminal requirements for the correct processing of a phosphatidylinositol-glycan anchored membrane protein.

1988 • 126 citations

Signal Peptide for Protein Secretion Directing Glycophospholipid Membrane Anchor Attachment

1989 • 120 citations

Selectivity of the cleavage/attachment site of phosphatidylinositol-glycan-anchored membrane proteins determined by site-specific mutagenesis at Asp-484 of placental alkaline phosphatase.

1990 • 114 citations

Variant surface glycoproteins of Trypanosoma brucei are synthesised with cleavable hydrophobic sequences at the carboxy and amino termini

1981 • 111 citations

Idealization of the hydrophobic segment of the alkaline phosphatase signal peptide

1986 • 98 citations

Polymeric sequences reveal a functional interrelationship between hydrophobicity and length of signal peptides.

1990 • 93 citations

Membrane Anchoring of a Human IgG Fc Receptor (CD16) Determined by a Single Amino Acid

1989 • 88 citations

Conversion of a PI-Anchored Protein to an Integral Membrane Protein by a Single Amino Acid Mutation

1988 • 70 citations

A nonfunctional sequence converted to a signal for glycophosphatidylinositol membrane anchor attachment.

1991 • 67 citations

Fusion of sequence elements from non-anchored proteins to generate a fully functional signal for glycophosphatidylinositol membrane anchor attachment.

1991 • 62 citations

Engineering of the hydrophobic segment of the signal sequence for efficient secretion of human lysozyme by Saccharomycescerevisiae

1987 • 62 citations

Functional limits of conformation, hydrophobicity, and steric constraints in prokaryotic signal peptide cleavage regions. Wild type transport by a simple polymeric signal sequence.

1991 • 61 citations

Molecular mapping of signals in the Qa-2 antigen required for attachment of the phosphatidylinositol membrane anchor.

1988 • 60 citations

Glycolipid reanchoring of T-lymphocyte surface antigen CD8 using the 3' end sequence of decay-accelerating factor's mRNA.

1988 • 55 citations

Hu Ly-m5: A unique antigen physically associated with HLA molecules

1983 • 54 citations

Biosynthesis of a phosphatidylinositol-glycan-linked membrane protein: signals for posttranslational processing of the Ly-6E antigen.

1989 • 26 citations