Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck – A systematic review and meta-analysis

Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints

1998 • 4,679 citations

Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients

2009 • 2,820 citations

Head and Neck Cancer

1993 • 2,263 citations

The Concentration of Oxygen Dissolved in Tissues at the Time of Irradiation as a Factor in Radiotherapy

1953 • 2,102 citations

The hazard of accelerated tumor clonogen repopulation during radiotherapy

1988 • 1,592 citations

Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis

2006 • 1,016 citations

Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck

1996 • 930 citations

Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study

2005 • 908 citations

Exploring the role of cancer stem cells in radioresistance

2008 • 791 citations

Critical Impact of Radiotherapy Protocol Compliance and Quality in the Treatment of Advanced Head and Neck Cancer: Results From TROG 02.02

2010 • 739 citations

Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6&7 randomised controlled trial

2003 • 645 citations

Effect of HPV-Associated p16^INK4A Expression on Response to Radiotherapy and Survival in Squamous Cell Carcinoma of the Head and Neck

2009 • 605 citations

Hypoxic Radiosensitization: Adored and Ignored

2007 • 593 citations

The current and potential role of hyperthermia in radiotherapy

1989 • 505 citations

Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene

2010 • 483 citations

Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers

1996 • 424 citations

Relation of a Hypoxia Metagene Derived from Head and Neck Cancer to Prognosis of Multiple Cancers

2007 • 366 citations

Tirapazamine, Cisplatin, and Radiation Versus Cisplatin and Radiation for Advanced Squamous Cell Carcinoma of the Head and Neck (TROG 02.02, HeadSTART): A Phase III Trial of the Trans-Tasman Radiation Oncology Group

2010 • 360 citations

Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer.

2002 • 354 citations

RADIOTHERAPY AND HYPERBARIC OXYGEN IN HEAD AND NECK CANCER

1977 • 321 citations

Multidisciplinary Rectal Cancer Management: 2nd European Rectal Cancer Consensus Conference (EURECA-CC2)

2009 • 296 citations

An interim report

1986 • 290 citations

A confirmatory prognostic study on oxygenation status and loco-regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy

2000 • 278 citations

Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial

2005 • 268 citations

ARCON: a novel biology-based approach in radiotherapy

2002 • 250 citations

Primary radiotherapy of larynx and pharynx carcinoma—An analysis of some factors influencing local control and survival

1986 • 241 citations

hsa‐miR‐210 is a marker of tumor hypoxia and a prognostic factor in head and neck cancer

2010 • 240 citations

Development of a Hypoxia Gene Expression Classifier with Predictive Impact for Hypoxic Modification of Radiotherapy in Head and Neck Cancer

2011 • 237 citations

RADIOTHERAPY AND HYPERBARIC OXYGEN IN HEAD AND NECK CANCER

1977 • 229 citations

The strengths and limitations of meta-analyses based on aggregate data

2005 • 228 citations

Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors.

1994 • 218 citations

Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of larynx and pharynx: Report from the DAHANCA 2 study

1989 • 216 citations

The Relationship Between Human Papillomavirus Status and Other Molecular Prognostic Markers in Head and Neck Squamous Cell Carcinomas

2009 • 210 citations

Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas.

2003 • 210 citations

HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer

2009 • 201 citations

Quality assurance in radiotherapy

1995 • 197 citations

The influence of HPV-associated p16-expression on accelerated fractionated radiotherapy in head and neck cancer: Evaluation of the randomised DAHANCA 6&7 trial

2011 • 188 citations

Results of an RTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole with radiotherapy alone for locally advanced head and neck carcinomas

1995 • 180 citations

Chemical sensitizers for hypoxic cells: A decade of experience in clinical radiotherapy

1985 • 177 citations

Evidence-based radiation oncology in head and neck squamous cell carcinoma

2007 • 175 citations

Dynamics of Tumor Hypoxia Measured with Bioreductive Hypoxic Cell Markers

2007 • 161 citations

Hypofractionation Results in Reduced Tumor Cell Kill Compared to Conventional Fractionation for Tumors With Regions of Hypoxia

2010 • 158 citations

Sensitization of Hypoxic Tumour Cells—Clinical Experience

1989 • 156 citations

The role of Human papillomavirus in head and neck cancer and the impact on radiotherapy outcome

2010 • 153 citations

Prospective Trial Incorporating Pre-/Mid-Treatment [18F]-Misonidazole Positron Emission Tomography for Head-and-Neck Cancer Patients Undergoing Concurrent Chemoradiotherapy

2009 • 125 citations

Expression and Prognostic Significance of a Panel of Tissue Hypoxia Markers in Head-and-Neck Squamous Cell Carcinomas

2007 • 119 citations

Five versus six fractions of radiotherapy per week for squamous-cell carcinoma of the head and neck (IAEA-ACC study): a randomised, multicentre trial

2010 • 118 citations

PET-CT for response assessment and treatment adaptation in head and neck cancer

2010 • 112 citations

Late results of a trial of hyperbaric oxygen and radiotherapy in head and neck cancer: A rationale for hypoxic cell sensitizers?

1986 • 110 citations

Combination of nicotinamide and hyperthermia to eliminate radioresistant chronically and acutely hypoxic tumor cells.

1990 • 106 citations

Nimorazole as a hypoxic radiosensitizer in the treatment of supraglottic larynx and pharynx carcinoma. First report from the Danish Head and Neck Cancer Study (DAHANCA) protocol 5-85

1991 • 94 citations

Clinical evidence on PET–CT for radiation therapy planning in head and neck tumours

2010 • 93 citations

Carbogen breathing during radiation therapy The radiation therapy oncology group study

1979 • 90 citations

Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation

2010 • 88 citations

Implementation of hypoxia imaging into treatment planning and delivery

2010 • 86 citations

Detection and Specific Targeting of Hypoxic Regions within Solid Tumors: Current Preclinical and Clinical Strategies

2008 • 85 citations

Validation of Lysyl Oxidase As a Prognostic Marker for Metastasis and Survival in Head and Neck Squamous Cell Carcinoma: Radiation Therapy Oncology Group Trial 90-03

2009 • 84 citations

Radiobiological basis and clinical results of the simultaneous integrated boost (SIB) in intensity modulated radiotherapy (IMRT) for head and neck cancer: A review

2009 • 83 citations

Differential risk assessments from five hypoxia specific assays: The basis for biologically adapted individualized radiotherapy in advanced head and neck cancer patients

2007 • 82 citations

Identifying hypoxia in human tumors: A correlation study between¹⁸F-FMISO PET and the Eppendorf oxygen-sensitive electrode

2010 • 79 citations

Results of a european randomized trial of Etanidazole combined with radiotherapy in head and neck carcinomas

1997 • 77 citations

CD133 expression is not selective for tumor-initiating or radioresistant cell populations in the CRC cell lines HCT-116

2009 • 75 citations

Early results of the EORTC randomized clinical trial on multiple fractions per day (MFD) and misonidazole in advanced head and neck cancer

1986 • 74 citations

Relationship between radiobiological hypoxia in tumors and electrode measurements of tumor oxygenation

1994 • 74 citations

Mechanism of action of the selective tumor radiosensitizer nicotinamide

1988 • 73 citations

Identifying pH independent hypoxia induced genes in human squamous cell carcinomasin vitro

2010 • 72 citations

Clinical results of hypoxic cell radiosensitisation from hyperbaric oxygen to accelerated radiotherapy, carbogen and nicotinamide.

1996 • 70 citations

Planning study for available dose of hypoxic tumor volume using fluorine-18-labeled fluoromisonidazole positron emission tomography for treatment of the head and neck cancer

2010 • 68 citations

Erythropoietin as an adjuvant treatment with (chemo) radiation therapy for head and neck cancer

2009 • 66 citations

Radiotherapy with or without mitomycin c in the treatment of locally advanced head and neck cancer: results of the IAEA multicentre randomised trial

2003 • 65 citations

The importance of haemoglobin level and effect of transfusion in HNSCC patients treated with radiotherapy – Results from the randomized DAHANCA 5 study

2010 • 59 citations

Failure of misonidazole-sensitized radiotherapy to impact upon outcome among stage III–IV squamous cancers of the head and neck

1987 • 58 citations

The EORTC randomized trial on three fractions per day and misonidazole (trial no. 22811) in advanced head and neck cancer: long-term results and side effects

1995 • 56 citations

The limitation of PET imaging for biological adaptive-IMRT assessed in animal models

2008 • 54 citations

Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast?

2009 • 51 citations

Fraction size in radiobiology and radiotherapy

1973 • 51 citations

Hyperbaric oxygen in radiation therapy. An investigation of dose-effect relationships in tumor response and tissue damage.

1968 • 50 citations

HYPERBARIC OXYGEN IN RADIATION THERAPY

1968 • 47 citations

Individual Patient- versus Literature-Based Meta-analysis of Survival Data

2001 • 45 citations

The potential advantages of 18FDG PET/CT-based target volume delineation in radiotherapy planning of head and neck cancer

2010 • 45 citations

A phase I/II study of the hypoxic cell sensitizer misonidazole as an adjunct to high fractional dose radiotherapy in patients with unresectable squamous cell carcinoma of the head and neck: A RTOG randomized study (#79-04)

1989 • 42 citations

New Developments in Radiation Therapy for Head and Neck Cancer: Intensity-Modulated Radiation Therapy and Hypoxia Targeting

2008 • 41 citations

Proteins upregulated by mild and severe hypoxia in squamous cell carcinomas in vitro identified by proteomics

2009 • 38 citations

Hyperbaric oxygenation for tumour sensitisation to radiotherapy: A systematic review of randomised controlled trials

2008 • 38 citations

RADIOTHERAPY OF ADVANCED CARCINOMA OF THE OROPHARYNGEAL REGION UNDER HYPERBARIC OXYGENATION

1973 • 37 citations

Hæmangiomatous Lesions of the Colon

1951 • 37 citations

Radiation therapy with hyperbaric oxygen at 4 atmospheres pressure in the management of squamous cell carcinoma of the head and neck: results of a randomized clinical trial.

1999 • 35 citations

Hyperbaric oxygen in radiation therapy

1977 • 32 citations

Irradiation with misonidazole and hyperbaric oxygen: Final report on a randomized trial in advanced head and neck cancer

1986 • 32 citations

Hyperthermia trials

1988 • 29 citations

Radiotherapy alone or combined with carbogen breathing for squamous cell carcinoma of the head and neck

2005 • 28 citations

An overview of the initial experience with AK-2123 as a hypoxic cell sensitizer with radiation in the treatment of advanced head and neck cancers

1996 • 26 citations

Triple angiokinase inhibition, tumour hypoxia and radiation response of FaDu human squamous cell carcinomas

2009 • 24 citations

The leeds results for radiotherapy in HBO for carcinoma of the head and neck

1979 • 24 citations

The role of hemoglobin concentration in the outcome of misonidazole-sensitized radiotherapy of head and neck cancers: Based on rtog trial #79-15

1989 • 23 citations

The use of a comprehensive tumour xenograft dataset to validate gene signatures relevant for radiation response

2009 • 20 citations

Radiation therapy of head and neck tumors: A randomized study of treatment in air vs. treatment in hyperbaric oxygen

1979 • 19 citations

A report on misonidazole in a randomized trial in locally advanced head and neck cancer

1982 • 19 citations

Targeting Hypoxia in Head and Neck Cancer

2001 • 19 citations

Hyperfractionated radiotherapy with or without misonidazole: Results of a prospective randomized study in stage III–IV squamous cell carcinoma of the head and neck

1984 • 18 citations

Acute Toxicity Profile and Compliance to Accelerated Radiotherapy Plus Carbogen and Nicotinamide for Clinical Stage T2–4 Laryngeal Cancer: Results of a Phase III Randomized Trial

2011 • 17 citations

A RANDOMIZED STUDY OF HYPERBARIC OXYGEN AS AN ADJUNCT TO REGULARLY FRACTIONATED RADIATION THERAPY FOR CLINICAL TREATMENT OF ADVANCED NEOPLASTIC DISEASE

1971 • 16 citations

Hyperbaric oxygen in the radiation treatment of head and neck cancers

1991 • 15 citations

International Clinical Trials in Radiation Oncology. Hyperthermia trials.

1988 • 12 citations

Safety and radiosensitizing efficacy of sanazole (AK 2123) in oropharyngeal cancers: Randomized controlled double blind clinical trial

2006 • 9 citations

Use of ornidazole in fractionated radiotherapy: Dose tolerance, serum and tumour tissue concentration

1986 • 8 citations

EXPLOSIVE DECOMPRESSION IN A HYPERBARIC OXYGEN CHAMBER

1971 • 7 citations

Clinical trial of atmospheric oxygen breathing during radiotherapy for cancer of the oropharynx.

1975 • 4 citations

Oxygen tension of oral cavity carcinoma.

1970 • 4 citations

[Comparison of the effectiveness of different methods of irradiation using metronidazole as a radiation-sensitizing agent in patients with laryngeal cancer. Controlled clinical studies].

1989 • 3 citations

COMORBIDITY AMONG 13,651 HEAD AND NECK CANCER PATIENTS FROM THE DAHANCA-DATABASE

2011 • 3 citations

[Controlled clinical studies].

1980 • 1 citations

Deleted Work

1955 • 0 citations