Hypofractionation Results in Reduced Tumor Cell Kill Compared to Conventional Fractionation for Tumors With Regions of Hypoxia

Exploiting tumour hypoxia in cancer treatment

2004 • 2,606 citations

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.

1996 • 1,747 citations

Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis

2003 • 1,538 citations

Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck

1997 • 1,057 citations

Fractionation and protraction for radiotherapy of prostate carcinoma

1999 • 931 citations

Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformality

2000 • 925 citations

Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study

2005 • 908 citations

Extracranial Stereotactic Radioablation *

2003 • 671 citations

The hypoxic cell: a target for selective cancer therapy--eighteenth Bruce F. Cain Memorial Award lecture.

1999 • 638 citations

Universal Survival Curve and Single Fraction Equivalent Dose: Useful Tools in Understanding Potency of Ablative Radiotherapy

2008 • 613 citations

High-Dose, Single-Fraction Image-Guided Intensity-Modulated Radiotherapy for Metastatic Spinal Lesions

2008 • 516 citations

The Linear-Quadratic Model Is an Appropriate Methodology for Determining Isoeffective Doses at Large Doses Per Fraction

2008 • 496 citations

Lethal and Potentially Lethal Lesions Induced by Radiation --- A Unified Repair Model

1986 • 469 citations

Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies

2000 • 345 citations

Cells at Intermediate Oxygen Levels Can Be More Important Than the "Hypoxic Fraction" in Determining Tumor Response to Fractionated Radiotherapy

1997 • 340 citations

Extending the linear–quadratic model for large fraction doses pertinent to stereotactic radiotherapy

2004 • 325 citations

The Phenomenon of Reoxygenation and Its Implications for Fractionated Radiotherapy

1972 • 296 citations

Oxygen diffusion and the distribution of cellular radiosensitivity in tumours

1972 • 267 citations

AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: Report of Task Group 137

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Review The link between low-LET dose-response relations and the underlying kinetics of damage production/repair/misrepair

1997 • 230 citations

Blood flow, oxygen consumption, and tissue oxygenation of human breast cancer xenografts in nude rats.

1987 • 183 citations

The Influence of Changes in Tumor Hypoxia on Dose-Painting Treatment Plans Based on 18F-FMISO Positron Emission Tomography

2008 • 173 citations

Is the α/β Value for Prostate Tumours Low Enough to be Safely Used in Clinical Trials?

2007 • 167 citations

The Repair-Misrepair Model in Radiobiology: Comparison to Other Models

1985 • 163 citations

Combined Use of Monte Carlo DNA Damage Simulations and Deterministic Repair Models to Examine Putative Mechanisms of Cell Killing

2008 • 140 citations

Cell kinetic measurements in prostate cancer

1997 • 138 citations

Polarographic electrode study of tumor oxygenation in clinically localized prostate cancer

2004 • 132 citations

Effects of oxygen on intrinsic radiation sensitivity: A test of the relationship between aerobic and hypoxic linear-quadratic (LQ) model parametersa)

2006 • 131 citations

Cell selection from a murine tumour using the fluorescent probe Hoechst 33342

1985 • 120 citations

Predictive value of in vitro radiosensitivity parameters in head and neck cancers and cervical carcinomas: Preliminary correlations with local control and overall survival

1993 • 114 citations

Comparison ofin vitroandin vivo / ratios for prostate cancer

2004 • 96 citations

The effect on the Km for radiosensitization at 0 degree C of thiol depletion by diethylmaleate pretreatment: quantitative differences found using the radiation sensitizing agent misonidazole or oxygen.

1984 • 83 citations

Is the alpha–beta ratio of prostate cancer really low? A prospective, non-randomized trial comparing standard and hyperfractionated conformal radiation therapy

2005 • 79 citations

Keynote address: Hypoxic cell radiosensitizers: Where next?

1989 • 71 citations

The role of misonidazole combined with intraoperative radiation therapy in the treatment of pancreatic carcinoma.

1987 • 68 citations

New insights into factors influencing the clinically relevant oxygen enhancement ratio

1998 • 63 citations

The Repair-Misrepair Model in Radiobiology: Comparison to Other Models

1985 • 60 citations

The Effect on the K m for Radiosensitization at 0 degrees C of Thiol Depletion by Diethylmaleate Pretreatment: Quantitative Differences Found Using the Radiation Sensitizing Agent Misonidazole or Oxygen

1984 • 58 citations

Fractionation sensitivities and dose-control relations of head and neck carcinomas: analysis of the randomized hyperfractionation trials

1999 • 56 citations

A Rapid-Mixing Comparison of the Mechanisms of Radiosensitization by Oxygen and Misonidazole in CHO Cells

1982 • 50 citations

Comparison of the comet assay and the oxygen microelectrode for measuring tumor oxygenation in head-and-neck cancer patients

2003 • 44 citations

The immunohistochemical assessment of hypoxia, vascularity and proliferation in bladder carcinoma

2004 • 44 citations

Oxygen Tension of Cervical Carcinoma during the Early Phase of External Irradiation II. Measurements with Bare Platinum Micro Electrodes

1971 • 36 citations

Interaction of misonidazole and oxygen in the radiosensitization of mammalian cells

1980 • 26 citations

RTOG #89-06: A phase I study to evaluate intraoperative radiation therapy and the hypoxic cell sensitizer etanidazole in locally advanced malignancies

1994 • 20 citations

A phase I-B trial of the radiosensitizer: Etanidazole (SR-2508) with radiosurgery for the treatment of recurrent previously irradiated primary brain tumors or brain metastases (RTOG Study 95-02)

2008 • 18 citations

Half-life Values for DNA Double-strand Break Rejoining in Yeast Can Vary by More Than an Order of Magnitude Depending on the Irradiation Conditions

1994 • 18 citations