Implementation of hypoxia imaging into treatment planning and delivery

Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck

1997 • 1,057 citations

Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck

1996 • 930 citations

Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformality

2000 • 925 citations

Tumor Hypoxia: Causative Factors, Compensatory Mechanisms, and Cellular Response

2004 • 718 citations

Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6&7 randomised controlled trial

2003 • 645 citations

Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: A pretherapy study of 37 patients

1996 • 563 citations

Prognostic Significance of [¹⁸F]-Misonidazole Positron Emission Tomography–Detected Tumor Hypoxia in Patients With Advanced Head and Neck Cancer Randomly Assigned to Chemoradiation With or Without Tirapazamine: A Substudy of Trans-Tasman Radiation Oncology Group Study 98.02

2006 • 533 citations

A novel approach to overcome hypoxic tumor resistance: Cu-ATSM-guided intensity-modulated radiation therapy

2001 • 434 citations

Theragnostic imaging for radiation oncology: dose-painting by numbers

2005 • 398 citations

Prognostic impact of hypoxia imaging with 18F-misonidazole PET in non-small cell lung cancer and head and neck cancer before radiotherapy.

2005 • 394 citations

Tumor Hypoxia Has Independent Predictor Impact Only in Patients With Node-Negative Cervix Cancer

2002 • 366 citations

Tumor Hypoxia Imaging with [F-18] Fluoromisonidazole Positron Emission Tomography in Head and Neck Cancer

2006 • 339 citations

Hypoxia-specific tumor imaging with 18F-fluoroazomycin arabinoside.

2005 • 317 citations

Hypoxia Dose Painting by Numbers: A Planning Study

2007 • 290 citations

A confirmatory prognostic study on oxygenation status and loco-regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy

2000 • 278 citations

Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial

2005 • 268 citations

ARCON: a novel biology-based approach in radiotherapy

2002 • 250 citations

Fluorine-18-Labeled Fluoromisonidazole Positron Emission and Computed Tomography-Guided Intensity-Modulated Radiotherapy for Head and Neck Cancer: A Feasibility Study

2007 • 233 citations

Hypoxia Imaging With FAZA-PET and Theoretical Considerations With Regard to Dose Painting for Individualization of Radiotherapy in Patients With Head and Neck Cancer

2007 • 227 citations

Reproducibility of Intratumor Distribution of 18F-Fluoromisonidazole in Head and Neck Cancer

2008 • 213 citations

Positron Emission Tomography-Guided, Focal-Dose Escalation Using Intensity-Modulated Radiotherapy for Head and Neck Cancer

2007 • 210 citations

Assessing Tumor Hypoxia in Cervical Cancer by PET with ⁶⁰Cu-Labeled Diacetyl-Bis(N⁴-Methylthiosemicarbazone)

2008 • 208 citations

Dose Painting in Radiotherapy for Head and Neck Squamous Cell Carcinoma: Value of Repeated Functional Imaging with¹⁸F-FDG PET,¹⁸F-Fluoromisonidazole PET, Diffusion-Weighted MRI, and Dynamic Contrast-Enhanced MRI

2009 • 201 citations

Tumor perfusion rate determined noninvasively by dynamic computed tomography predicts outcome in head-and-neck cancer after radiotherapy

2003 • 188 citations

¹⁸F-EF5: A New PET Tracer for Imaging Hypoxia in Head and Neck Cancer

2008 • 184 citations

An Imaging Comparison of ⁶⁴Cu-ATSM and ⁶⁰Cu-ATSM in Cancer of the Uterine Cervix

2008 • 182 citations

Tumour hypoxia imaging with [18F]FAZA PET in head and neck cancer patients: a pilot study

2007 • 174 citations

The Influence of Changes in Tumor Hypoxia on Dose-Painting Treatment Plans Based on 18F-FMISO Positron Emission Tomography

2008 • 173 citations

Kinetic analysis of dynamic 18F-fluoromisonidazole PET correlates with radiation treatment outcome in head-and-neck cancer

2005 • 170 citations

The Pervasive Presence of Fluctuating Oxygenation in Tumors

2008 • 170 citations

[18F]fluoro-deoxy-glucose positron emission tomography ([18F]FDG-PET) voxel intensity-based intensity-modulated radiation therapy (IMRT) for head and neck cancer

2006 • 165 citations

A kinetic model for dynamic [¹⁸F]-Fmiso PET data to analyse tumour hypoxia

2005 • 164 citations

Microvascular studies on the origins of perfusion-limited hypoxia.

1996 • 162 citations

Tumor Hypoxia Detected by Positron Emission Tomography with 60Cu-ATSM as a Predictor of Response and Survival in Patients Undergoing Neoadjuvant Chemoradiotherapy for Rectal Carcinoma: A Pilot Study

2008 • 156 citations

On biologically conformal boost dose optimization

2003 • 151 citations

Utility of FMISO PET in advanced head and neck cancer treated with chemoradiation incorporating a hypoxia-targeting chemotherapy agent

2005 • 139 citations

Vascular architecture, hypoxia, and proliferation in first-generation xenografts of human head-and-neck squamous cell carcinomas

2002 • 128 citations

Prospective Trial Incorporating Pre-/Mid-Treatment [18F]-Misonidazole Positron Emission Tomography for Head-and-Neck Cancer Patients Undergoing Concurrent Chemoradiotherapy

2009 • 125 citations

Hypoxia-imaging with 18F-Misonidazole and PET: Changes of kinetics during radiotherapy of head-and-neck cancer

2007 • 120 citations

[18F] fluoromisonidazole and [18F] fluorodeoxyglucose positron emission tomography in response evaluation after chemo-/radiotherapy of non-small-cell lung cancer: a feasibility study

2006 • 117 citations

Intermittent Hypoxia Furthers the Rationale for Hypoxia-Inducible Factor-1 Targeting

2007 • 105 citations

The prognostic value of endogenous hypoxia-related markers for head and neck squamous cell carcinomas treated with ARCON

2006 • 97 citations

Correlation of [18F]FMISO autoradiography and pimonodazole immunohistochemistry in human head and neck carcinoma xenografts

2008 • 87 citations

Strategies for Biologic Image-Guided Dose Escalation: A Review

2009 • 84 citations

Hypoxia in Breast Cancer

2006 • 81 citations

Imaging Hypoxia in Xenografted and Murine Tumors With 18F-Fluoroazomycin Arabinoside: A Comparative Study Involving microPET, Autoradiography, Po2-Polarography, and Fluorescence Microscopy

2008 • 80 citations

A Model of Reoxygenation Dynamics of Head-And-Neck Tumors Based on Serial 18F-Fluoromisonidazole Positron Emission Tomography Investigations

2007 • 78 citations

Radiotherapy Adapted to Spatial and Temporal Variability in Tumor Hypoxia

2007 • 72 citations

Intensity-modulated x-ray (IMXT) versus proton (IMPT) therapy for theragnostic hypoxia-based dose painting

2008 • 68 citations

Resolution in PET hypoxia imaging: Voxel size matters

2008 • 67 citations

Dose painting with IMPT, helical tomotherapy and IMXT: A dosimetric comparison

2007 • 64 citations

Oxygen and glucose consumption in gastrointestinal adenocarcinomas: Correlation with markers of hypoxia, acidity and anaerobic glycolysis

2006 • 59 citations

Metabolic control probability in tumour subvolumes or how to guide tumour dose redistribution in non-small cell lung cancer (NSCLC): An exploratory clinical study

2009 • 54 citations

Outcome Prediction After Surgery and Chemoradiation of Squamous Cell Carcinoma in the Oral Cavity, Oropharynx, and Hypopharynx: Use of Baseline Perfusion CT Microcirculatory Parameters vs. Tumor Volume

2008 • 49 citations

Patterns of tumor oxygenation and their influence on the cellular hypoxic response and hypoxia-directed therapies

2006 • 40 citations

Determination of tumour hypoxia with [18F]EF3 in patients with head and neck tumours: a phase I study to assess the tracer pharmacokinetics, biodistribution and metabolism

2008 • 35 citations

Application of the Inverse Monte Carlo Treatment Planning System IKO for an Inhomogeneous Dose Prescription in the Sense of Dose Painting

2006 • 10 citations

Prediction of early response to radiotherapy of uterine carcinoma with dynamic contrast-enhanced MR imaging using pixel analysis of MR perfusion imaging

2008 • 6 citations