Cardiolipin-Specific Peroxidase Reactions of Cytochrome c in Mitochondria During Irradiation-Induced Apoptosis

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Mitochondria and Apoptosis

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Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

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Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

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Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

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A model for p53-induced apoptosis

1997 • 2,502 citations

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

Cytochrome C-Mediated Apoptosis

2004 • 1,297 citations

Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

2005 • 1,169 citations

Cytochrome c release from mitochondria proceeds by a two-step process

2002 • 917 citations

Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide

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Determination of lipid phosphorus in the nanomolar range

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Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis

2000 • 337 citations

Decreased Cardiolipin Synthesis Corresponds with Cytochromec Release in Palmitate-induced Cardiomyocyte Apoptosis

2001 • 290 citations

Cardiolipin and apoptosis

2002 • 260 citations

The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles

2000 • 247 citations

Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis

2000 • 239 citations

Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in HL60 cells that overexpress Bcl‐2

2002 • 219 citations

Myocardial ischemia selectively depletes cardiolipin in rabbit heart subsarcolemmal mitochondria

2001 • 191 citations

Mitochondrial Localization of Superoxide Dismutase is Required for Decreasing Radiation-Induced Cellular Damage

2003 • 148 citations

Mitochondrial Targeting of Selective Electron Scavengers: Synthesis and Biological Analysis of Hemigramicidin−TEMPO Conjugates

2005 • 147 citations

Evidence for Redox Regulation of Cytochrome c Release during Programmed Neuronal Death: Antioxidant Effects of Protein Synthesis and Caspase Inhibition

2001 • 127 citations

Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts

1998 • 120 citations

Redox regulation of apoptotic cell death

1998 • 120 citations

Phospholipid signaling in apoptosis: peroxidation and externalization of phosphatidylserine

2000 • 119 citations

Cytochrome c binding to Apaf-1: The effects of dATP and ionic strength

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Mitochondrial redox signaling during apoptosis.

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Potential use of nitroxides in radiation oncology.

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Peroxidation and externalization of phosphatidylserine associated with release of cytochrome c from mitochondria

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Molecular mechanisms of irradiation-induced apoptosis

2003 • 48 citations

The Plasma Membrane Is the Site of Selective Phosphatidylserine Oxidation During Apoptosis: Role of Cytochromec

2004 • 41 citations

Sensitive and Specific Fluorescent Probing of Oxidative Stress in Different Classes of Membrane Phospholipids in Live Cells Using Metabolically Integrated cis-Parinaric Acid

2003 • 30 citations

Apoptosis induced by ionizing radiation. The biological basis of radiosensitivity.

2002 • 25 citations

Radiation Biophysics. 2<sup>nd</sup> Ed.

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Apoptosis Induced by Ionizing Radiation

2006 • 20 citations

Pinocytic loading of cytochrome c into intact cells specifically induces caspase-dependent permeabilization of mitochondria: evidence for a cytochrome c feedback loop

2001 • 17 citations