Mitochondrial Localization of Superoxide Dismutase is Required for Decreasing Radiation-Induced Cellular Damage

Mitochondria and Apoptosis

1998 • 8,909 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems

1991 • 1,555 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis

2002 • 1,015 citations

Superoxide Dismutase

1973 • 887 citations

Reactive oxygen species are downstream mediators of p53-dependent apoptosis.

1996 • 590 citations

Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines.

1983 • 559 citations

Posttranslational N-Myristoylation of BID as a Molecular Switch for Targeting Mitochondria and Apoptosis

2000 • 555 citations

Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen.

2001 • 497 citations

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2

1997 • 489 citations

p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha.

1998 • 363 citations

Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin‐1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation

1993 • 351 citations

Glucose Deprivation-induced Cytotoxicity and Alterations in Mitogen-activated Protein Kinase Activation Are Mediated by Oxidative Stress in Multidrug-resistant Human Breast Carcinoma Cells

1998 • 229 citations

Synthesis and processing of the precursor for human mangano-superoxide dismutase

1989 • 199 citations

Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy

1998 • 179 citations

Protective roles of cytokines against radiation: Induction of mitochondrial MnSOD

1995 • 172 citations

p21waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases

1998 • 162 citations

Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells

1999 • 158 citations

Intratracheal injection of adenovirus containing the human MNSOD transgene protects athymic nude mice from irradiation-induced organizing alveolitis

1999 • 151 citations

Human Cu/Zn superoxide dismutase cDNA: isolation of clones synthesising high levels of active or inactive enzyme from an expression library

1985 • 149 citations

DNA damage and repair following treatment with ionizing radiation

1990 • 135 citations

Manganese Superoxide Dismutase (SOD2) Inhibits Radiation-Induced Apoptosis by Stabilization of the Mitochondrial Membrane

2002 • 130 citations

Modulation of Radiation-Induced Cytokine Elevation Associated with Esophagitis and Esophageal Stricture by Manganese Superoxide Dismutase-Plasmid/Liposome (SOD2-PL) Gene Therapy

2001 • 124 citations

Overexpression of manganese-containing superoxide dismutase confers resistance to the cytotoxicity of tumor necrosis factor alpha and/or hyperthermia.

1997 • 122 citations

Oxygen Stress Induces an Apoptotic Cell Death Associated with Fragmentation of Mitochondrial Genome

1995 • 98 citations

Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy

2002 • 91 citations

Identification of Respiratory Complexes I and III as Mitochondrial Sites of Damage Following Exposure to Ionizing Radiation and Nitric Oxide

2001 • 81 citations

Prevention of irradiation-induced esophagitis by plasmid/liposome delivery of the human manganese superoxide dismutase transgene

1999 • 78 citations

Cell phenotype specific kinetics of expression of intratracheally injected manganese superoxide dismutase–plasmid/liposomes (MnSOD–PL) during lung radioprotective gene therapy

2003 • 51 citations

Overexpression of the human manganese superoxide dismutase (MnSOD) transgene in subclones of murine hematopoietic progenitor cell line 32D cl 3 decreases irradiation-induced apoptosis but does not alter G2/M or G1/S phase cell cycle arrest

1999 • 50 citations

Inhibition of p53-dependent apoptosis by the KIT tyrosine kinase: regulation of mitochondrial permeability transition and reactive oxygen species generation

1998 • 45 citations

Radiosensitivity of permanent human bone marrow stromal cell lines: Effect of dose rate

1988 • 31 citations

Prevention of irradiation-induced esophagitis by intraesophageal plasmid/liposome delivery of the human manganese superoxide dismutase (MNSOD) transgene

1998 • 17 citations

Expression of the human BCL‐2 transgene increases the radiation resistance of a hematopoietic progenitor cell line

1994 • 16 citations