How a Single T Cell Receptor Recognizes Both Self and Foreign MHC

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T-cell antigen receptor genes and T-cell recognition

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Positive and Negative Selection of T Cells

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Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

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HOW TCRS BIND MHCS, PEPTIDES, AND CORECEPTORS

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The somatic generation of immune recognition

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Pushing the boundaries of molecular replacement with maximum likelihood

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Positive and negative selection of an antigen receptor on T cells in transgenic mice

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Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

1998 • 685 citations

The Molecular Basis of Allorecognition

1993 • 398 citations

Structural determinants of T-cell receptor bias in immunity

2006 • 362 citations

Quantitative Analysis of the Contribution of TCR/pepMHC Affinity and CD8 to T Cell Activation

2003 • 355 citations

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

1997 • 322 citations

TCR Binding to Peptide-MHC Stabilizes a Flexible Recognition Interface

1999 • 306 citations

In vitroevolution of a T cell receptor with high affinity for peptide/MHC

2000 • 288 citations

A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein

1992 • 286 citations

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I–bound peptide

2005 • 268 citations

CDR3 loop flexibility contributes to the degeneracy of TCR recognition

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Evidence that Structural Rearrangements and/or Flexibility during TCR Binding Can Contribute to T Cell Activation

2003 • 250 citations

Unconventional topology of self peptide–major histocompatibility complex binding by a human autoimmune T cell receptor

2005 • 249 citations

Directed evolution of a stable scaffold for T-cell receptor engineering

2000 • 229 citations

Crystal structure of a T cell receptor bound to an allogeneic MHC molecule

2000 • 208 citations

A T Cell Receptor CDR3β Loop Undergoes Conformational Changes of Unprecedented Magnitude Upon Binding to a Peptide/MHC Class I Complex

2002 • 206 citations

Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone.

1996 • 205 citations

A Functional Hot Spot for Antigen Recognition in a Superagonist TCR/MHC Complex

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High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.

1994 • 200 citations

High determinant density may explain the phenomenon of alloreactivity

1984 • 194 citations

Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera.

1984 • 183 citations

The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

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How the T Cell Receptor Sees Antigen—A Structural View

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Selection of functional T cell receptor mutants from a yeast surface-display library

1999 • 171 citations

Alanine Scanning Mutagenesis of an αβ T Cell Receptor: Mapping the Energy of Antigen Recognition

1998 • 163 citations

Structural Basis of 2C TCR Allorecognition of H-2Ld Peptide Complexes

1998 • 160 citations

Structure of an Autoimmune T Cell Receptor Complexed with Class II Peptide-MHC

2005 • 154 citations

Convergent Mechanisms for Recognition of Divergent Cytokines by the Shared Signaling Receptor gp130

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αβ T cell receptor interactions with syngeneic and allogeneic ligands: Affinity measurements and crystallization

1997 • 147 citations

What do TCR–pMHC crystal structures teach us about MHC restriction and alloreactivity?

2003 • 121 citations

A Basis for Alloreactivity: MHC Helical Residues Broaden Peptide Recognition by the TCR

1998 • 110 citations

Two Different T Cell Receptors use Different Thermodynamic Strategies to Recognize the Same Peptide/MHC Ligand

2004 • 108 citations

Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide

2006 • 102 citations

Structural Comparison of Allogeneic and Syngeneic T Cell Receptor–Peptide-Major Histocompatibility Complex Complexes

2002 • 97 citations

Rare, Structurally Homologous Self-Peptides Promote Thymocyte Positive Selection

2002 • 95 citations

A Correlation between TCR Vα Docking on MHC and CD8 Dependence

2003 • 92 citations

Structure of an Autoimmune T Cell Receptor Complexed with Class II Peptide-MHCInsights into MHC Bias and Antigen Specificity

2005 • 91 citations

Thermodynamic Analysis of Degenerate Recognition by the NKG2D Immunoreceptor

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The three-dimensional structure of an H-2L^d-peptide complex explains the unique interaction of L^dwith beta-2 microglobulin and peptide

1997 • 83 citations

Alloreactivity between Disparate Cognate and Allogeneic pMHC-I Complexes Is the Result of Highly Focused, Peptide-dependent Structural Mimicry

2006 • 57 citations

Disparate thermodynamics governing T cell receptor–MHC-I interactions implicate extrinsic factors in guiding MHC restriction

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Role of 2c T Cell Receptor Residues in the Binding of Self–And Allo–Major Histocompatibility Complexes

2000 • 53 citations

Distinct Molecular Mechanisms Account for the Specificity of Two Different T-Cell Receptors

2003 • 52 citations

Engineering and Characterization of a Stabilized α1/α2 Module of the Class I Major Histocompatibility Complex Product Ld

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Degenerate Recognition of Alloantigenic Peptides on a Positive-Selecting Class I Molecule

1998 • 44 citations

A model T-cell receptor system for studying memory T-cell development

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The peptide p2Ca is immunodominant in allorecognition of Ld by beta chain variable region V beta 8+ but not V beta 8- strains.

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A residue in the center of peptide QL9 affects binding to both Ld and the T cell receptor.

1996 • 35 citations

Structural features of MHC class I molecules that might facilitate alternative pathways of presentation

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Predominant utilization of V beta 8+ T cell receptor genes in the H-2Ld-restricted cytotoxic T cell response against the immediate-early protein pp89 of the murine cytomegalovirus.

1989 • 28 citations

Alloreactive and syngeneic CTL are comparably dependent on interaction with MHC class I alpha-helical residues.

1999 • 21 citations

Alloreactive and Syngeneic CTL Are Comparably Dependent on Interaction with MHC Class I α-Helical Residues

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Development of CD4⁺T cells expressing a nominally MHC class I-restricted T cell receptor by two different mechanisms

2006 • 14 citations

Sequence restrictions in T cell receptor β-chains that have specificity for a self-peptide/Ld complex

1994 • 11 citations