Synergistic enhancement of globin gene expression by activator protein-1-like proteins.

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,865 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

1989 • 931 citations

Firefly Luciferase Gene: Structure and Expression in Mammalian Cells

1987 • 924 citations

Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation.

1984 • 889 citations

Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40

1987 • 762 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

Molecular cloning and characterization of the human β-like globin gene cluster

1980 • 452 citations

Two tissue-specific factors bind the erythroid promoter of the human porphobilinogen deaminase gene

1989 • 326 citations

Detailed analysis of the site 3 region of the human beta-globin dominant control region.

1990 • 320 citations

Sequence-specific interactions of nuclear factors with the insulin gene enhancer

1986 • 309 citations

Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells.

1990 • 301 citations

An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes.

1989 • 280 citations

Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene.

1989 • 272 citations

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.

1989 • 269 citations

Transcription factors: a new family gathers at the cAMP response site

1990 • 244 citations

Gamma delta beta-thalassemia due to a de novo mutation deleting the 5' beta-globin gene activation-region hypersensitive sites.

1989 • 240 citations

A dimer of AraC protein contacts three adjacent major groove regions of the araI DNA site.

1985 • 197 citations

Human fetal to adult hemoglobin switching: changes in chromatin structure of the beta-globin gene locus.

1983 • 190 citations

Chromosomal localization of human β globin gene on human chromosome 11 in somatic cell hybrids

1978 • 189 citations

γ-β-Thalassaemia studies showing that deletion of the γ- and δ-genes influences β-globin gene expression in man

1980 • 184 citations

Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site.

1989 • 122 citations

A distant gene deletion affects beta-globin gene function in an atypical gamma delta beta-thalassemia.

1985 • 106 citations

γδβ-Thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human β-globin cluster

1986 • 95 citations

Assignment of human beta-, gamma-, and delta-globin genes to the short arm of chromosome 11 by chromosome sorting and DNA restriction enzyme analysis.

1979 • 91 citations