Multiple Mechanisms of Na ⁺ Channel– Linked Long-QT Syndrome

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

1995 • 2,391 citations

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

1995 • 2,263 citations

Cardiac Electrophysiology: From Cell to Bedside

1991 • 2,234 citations

Neuronal NADPH diaphorase is a nitric oxide synthase.

1991 • 1,917 citations

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

1996 • 1,746 citations

Redox signaling: Nitrosylation and related target interactions of nitric oxide

1994 • 1,732 citations

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

1995 • 1,686 citations

The "megaprimer" method of site-directed mutagenesis.

1990 • 1,174 citations

Molecular mechanism for an inherited cardiac arrhythmia

1995 • 964 citations

A NEW FAMILIAL CARDIAC SYNDROME IN CHILDREN.

1964 • 842 citations

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.

1992 • 810 citations

Long QT Syndrome Patients With Mutations of the SCN5A and HERG Genes Have Differential Responses to Na ⁺ Channel Blockade and to Increases in Heart Rate

1995 • 801 citations

Complexes of ^.NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects

1991 • 724 citations

The long QT syndrome

1997 • 709 citations

Control of cardiac muscle cell function by an endogenous nitric oxide signaling system.

1993 • 656 citations

Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel.

1992 • 624 citations

Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

1992 • 623 citations

Linkage of a Cardiac Arrhythmia, the Long QT Syndrome, and the Harvey ras -1 Gene

1991 • 526 citations

The steady state TTX-sensitive (?window?) sodium current in cardiac Purkinje fibres

1979 • 468 citations

Regulation of cardiac ion channels by catecholamines, acetylcholine and second messenger systems

1988 • 403 citations

Mapping of a gene for long QT syndrome to chromosome 4q25-27.

1995 • 356 citations

Action potential prolongation and induction of abnormal automaticity by low quinidine concentrations in canine Purkinje fibers. Relationship to potassium and cycle length.

1985 • 341 citations

Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia

1995 • 337 citations

Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity

1994 • 270 citations

QTU prolongation and polymorphic ventricular tachyarrhythmias due to bradycardia-dependent early afterdepolarizations. Afterdepolarizations and ventricular arrhythmias.

1988 • 248 citations

Slow currents through single sodium channels of the adult rat heart.

1985 • 242 citations

Cardiac Na currents and the inactivating, reopening, and waiting properties of single cardiac Na channels.

1985 • 239 citations

Nitric oxide donor SIN-1 inhibits mammalian cardiac calcium current through cGMP-dependent protein kinase

1995 • 218 citations

An obligatory role for nitric oxide in autonomic control of mammalian heart rate.

1994 • 215 citations

Cyclic guanosine 3',5'‐monophosphate regulates the calcium current in single cells from frog ventricle.

1987 • 199 citations

Quinidine-induced action potential prolongation, early afterdepolarizations, and triggered activity in canine Purkinje fibers. Effects of stimulation rate, potassium, and magnesium.

1989 • 198 citations

Late sodium current and its contribution to action potential configuration in guinea pig ventricular myocytes.

1989 • 192 citations

Muscarinic control of the hyperpolarization‐activated current (if) in rabbit sino‐atrial node myocytes.

1988 • 178 citations

Potentiation by cyclic GMP of beta‐adrenergic effect on Ca2+ current in guinea‐pig ventricular cells.

1991 • 167 citations

Fast and slow gating of sodium channels encoded by a single mRNA

1990 • 162 citations

Electrophysiological Actions of Lidocaine on Canine Ventricular Muscle and Purkinje Fibers

1969 • 161 citations

Methylene blue inhibits nitrovasodilator- and endothelium-derived relaxing factor-induced cyclic GMP accumulation in cultured pulmonary arterial smooth muscle cells via generation of superoxide anion.

1992 • 149 citations

Voltage clamping of Xenopus laevis oocytes utilizing agarose-cushion electrodes

1994 • 145 citations

Effects of III-IV linker mutations on human heart Na+ channel inactivation gating.

1994 • 140 citations

Slow inactivation of the sodium current in rabbit cardiac Purkinje fibres

1987 • 140 citations

LY83583: an agent that lowers intracellular levels of cyclic guanosine 3',5'-monophosphate.

1985 • 133 citations

CONGENITAL CARDIAC ARRHYTHMIA

1964 • 133 citations

Slow inactivation of a tetrodotoxin-sensitive current in canine cardiac Purkinje fibers

1984 • 126 citations

Assignment of the human heart tetrodotoxin-resistant voltage-gated Na<sup>+</sup> channel α-subunit gene (SCN5A) to band 3p21

1995 • 121 citations

Nitric oxide synthase immunoreactivity and NADPH-diaphorase activity in a subpopulation of intrinsic neurones of the guinea-pig heart

1992 • 111 citations

Right ventricular monophasic action potentials in patients with long QT syndrome.

1978 • 106 citations

Characterization of the sodium current in single human atrial myocytes.

1992 • 101 citations

Depressant effect of magnesium on early afterdepolarizations and triggered activity induced by cesium, quinidine, and 4-aminopyridine in canine cardiac Purkinje fibers

1989 • 100 citations

Modal gating behavior of cardiac sodium channels in cell-free membrane patches

1988 • 96 citations

Kinetic properties of single sodium channels in rat heart and rat brain.

1989 • 90 citations

Afterdepolarizations as a mechanism for the long QT syndrome: Electrophysiologic studies of a case

1984 • 89 citations

Mechanism of muscarinic control of the high-threshold calcium current in rabbit sino-atrial node myocytes

1993 • 79 citations

Epinephrine‐Induced Ventricular Premature Complexes Due to Early Afterdepolarizations and Effects of Verapamil and Propranolol in a Patient with Congenital Long QT Syndrome

1994 • 50 citations

Ca(++)-dependent constitutive nitric oxide synthase is not involved in the cyclic GMP-increasing effects of carbachol in ventricular cardiomyocytes.

1993 • 43 citations

Monophasic Action Potential Studies in Human Subjects with Prolonged Ventricular Repolarization and Long QT Syndromes

1985 • 35 citations

Effects of the cyclic GMP lowering agent LY83583 on the interaction of carbachol with forskolin in rabbit isolated cardiac preparations.

1986 • 35 citations

Role of Early Afterdepolarization in Familial Long QTU Syndrome and Torsade de Pointes

1992 • 24 citations

Effects of Magnesium on Polymorphic Ventricular Tachycardias Induced by Aconitine

1994 • 23 citations

Stability of histamine dihydrochloride in solution

1988 • 12 citations

Potassium Channels in Mammalian Brain: A Molecular Approach

1994 • 10 citations

Treatment of Torsade de pointes with intravenous magnesium in idiopathic long QT syndrome.

1991 • 8 citations

Quinidine but Not Disopyramide Prolongs Cardiac Purkinje Fiber Action Potentials After a Pause

1994 • 8 citations

Association of Humps on Monophasic Action Potentials and ST‐T Alternans in a Patient with Romano‐Ward Syndrome

1991 • 7 citations

Torsade de pointes: Successful acute control by lidocaine and chronic control by tocainide in two patients—one each with acquired long QT and the congenital long QT syndrome

1986 • 5 citations