Genetically Defined Therapy of Inherited Long-QT Syndrome

An analysis of the time-relations of electrocardiograms

1920 • 3,889 citations

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

1995 • 2,391 citations

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

1995 • 2,263 citations

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

1995 • 1,686 citations

Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval, and sudden death

1957 • 1,593 citations

QT dispersion: an indication of arrhythmia risk in patients with long QT intervals.

1990 • 1,199 citations

Diagnostic criteria for the long QT syndrome. An update.

1993 • 1,160 citations

A family of potassium channel genes related to eag in Drosophila and mammals.

1994 • 960 citations

A NEW FAMILIAL CARDIAC SYNDROME IN CHILDREN.

1964 • 842 citations

Long QT Syndrome Patients With Mutations of the SCN5A and HERG Genes Have Differential Responses to Na ⁺ Channel Blockade and to Increases in Heart Rate

1995 • 801 citations

Linkage of a Cardiac Arrhythmia, the Long QT Syndrome, and the Harvey ras -1 Gene

1991 • 526 citations

Electrical alternation of the T-wave: Clinical and experimental evidence of its relationship with the sympathetic nervous system and with the long Q-T syndrome

1975 • 524 citations

Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia.

1996 • 465 citations

The long QT syndrome: a prospective international study.

1985 • 465 citations

Extracellular Potassium Modulation of Drug Block of I _Kr

1996 • 437 citations

Dispersion of the QT interval. A marker of therapeutic efficacy in the idiopathic long QT syndrome.

1994 • 401 citations

Left cardiac sympathetic denervation in the therapy of congenital long QT syndrome. A worldwide report.

1991 • 375 citations

Mapping of a gene for long QT syndrome to chromosome 4q25-27.

1995 • 356 citations

QT Dispersion: Problems of Methodology and Clinical Significance

1994 • 307 citations

Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity

1994 • 270 citations

Electrophysiologic Mechanisms of the Long QT Interval Syndromes and Torsade de Pointes

1995 • 269 citations

Carnitine deficiency presenting as familial cardiomyopathy: A treatable defect in carnitine transport

1982 • 235 citations

Efficacy of permanent pacing in the management of high-risk patients with long QT syndrome.

1991 • 197 citations

Role of external Ca2+ and K+ in gating of cardiac delayed rectifier K+ currents

1992 • 190 citations

Quantitative analysis of T wave abnormalities and their prognostic implications in the idiopathic long QT syndrome

1994 • 185 citations

Relation between ventricular repolarization duration and cardiac cycle length during 24-hour Holter recordings. Findings in normal patients and patients with long QT syndrome.

1992 • 175 citations

Assessment of QT dispersion in symptomatic patients with congenital long QT syndromes

1992 • 168 citations

Combined use of beta-adrenergic blocking agents and long-term cardiac pacing for patients with the long QT syndrome

1992 • 146 citations

The Idiopathic Long QT Syndrome: Pathogenetic Mechanisms and Therapy

1985 • 146 citations

Pulmonary artery hemodynamics in primary pulmonary hypertension

1993 • 144 citations

Effects of exercise on heart rate, QT, QTc and QQS2 in the Romano-Ward inherited long QT syndrome

1991 • 135 citations

Effects of age, sex, and body habitus on QRS and ST-T potential maps of 1100 normal subjects.

1985 • 117 citations

Mapping of body surface potentials in patients with the idiopathic long QT syndrome.

1986 • 115 citations

Long QT syndrome. New electrocardiographic characteristics.

1990 • 106 citations

Unsuspected echocardiographic abnormality in the long QT syndrome. Diagnostic, prognostic, and pathogenetic implications.

1991 • 103 citations

Cardiac alterations in 36 consecutive patients with idiopathic haemochromatosis: polygraphic and echocardiographic evaluation

1991 • 88 citations

Genetic determinants of responsiveness to the HMG-CoA reductase inhibitor fluvastatin in patients with molecularly defined heterozygous familial hypercholesterolemia.

1993 • 81 citations

Differential Response of QTU Interval to Exercise, Isoproterenol, and Atrial Pacing in Patients with Congenital Long QT Syndrome

1991 • 64 citations