Pathophysiological Mechanisms of Dominant and Recessive KvLQT1 K+ Channel Mutations Found in Inherited Cardiac Arrhythmias

Ionic channels of excitable membranes

1985 • 7,199 citations

The American Journal of Human Genetics

1950 • 5,048 citations

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

1995 • 2,263 citations

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

1996 • 1,746 citations

Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel

1996 • 1,741 citations

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

1995 • 1,686 citations

Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval, and sudden death

1957 • 1,593 citations

KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium current

1996 • 1,585 citations

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

1995 • 1,216 citations

Diagnostic criteria for the long QT syndrome. An update.

1993 • 1,160 citations

Molecular mechanism for an inherited cardiac arrhythmia

1995 • 964 citations

A family of potassium channel genes related to eag in Drosophila and mammals.

1994 • 960 citations

A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome

1997 • 878 citations

A NEW FAMILIAL CARDIAC SYNDROME IN CHILDREN.

1964 • 842 citations

Mutations in the K+ channel signature sequence

1994 • 828 citations

Cloning of a Membrane Protein That Induces a Slow Voltage-Gated Potassium Current

1988 • 511 citations

Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia.

1996 • 465 citations

Mapping of a gene for long QT syndrome to chromosome 4q25-27.

1995 • 356 citations

Human KVLQT1 gene shows tissue-specific imprinting and encompasses Beckwith-Wiedemann syndrome chromosomal rearrangements

1997 • 354 citations

Heteromultimeric CLC chloride channels with novel properties

1996 • 246 citations

Multimeric structure of ClC-1 chloride channel revealed by mutations in dominant myotonia congenita (Thomsen).

1994 • 219 citations

KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias

1997 • 214 citations

Spectrum of mutations in the major human skeletal muscle chloride channel gene (CLCN1) leading to myotonia.

1995 • 162 citations

Site-specific mutations in a minimal voltage-dependent K+ channel alter ion selectivity and open-channel block

1991 • 132 citations

Four Novel KVLQT1 and Four Novel HERG Mutations in Familial Long-QT Syndrome

1997 • 117 citations

Alteration of channel activities and gating by mutations of slow ISK potassium channel.

1991 • 112 citations

MinK Residues Line a Potassium Channel Pore

1996 • 92 citations

KVLQT1 mutations in three families with familial or sporadic long QT syndrome

1996 • 80 citations

Interactions of the H5 pore region and hydroxylamine with N-type inactivation in the Shaker K+ channel

1995 • 18 citations