Activated MEK1 Binds the Nuclear MyoD Transcriptional Complex to Repress Transactivation

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

Signaling—2000 and Beyond

2000 • 2,544 citations

GAL4-VP16 is an unusually potent transcriptional activator

1988 • 1,379 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

1997 • 1,195 citations

Immunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitro.

1982 • 932 citations

MyoD1: A Nuclear Phosphoprotein Requiring a Myc Homology Region to Convert Fibroblasts to Myoblasts

1988 • 839 citations

Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins

1995 • 817 citations

p38 and Extracellular Signal-Regulated Kinases Regulate the Myogenic Program at Multiple Steps

2000 • 470 citations

p38 Mitogen-activated Protein Kinase Pathway Promotes Skeletal Muscle Differentiation

1999 • 444 citations

Functional antagonism between c-Jun and MyoD proteins: A direct physical association

1992 • 424 citations

Differential Roles of p300 and PCAF Acetyltransferases in Muscle Differentiation

1997 • 419 citations

Molecular mechanisms regulating myogenic determination and differentiation

2000 • 375 citations

Molecular Mechanisms of Myogenic Coactivation by p300: Direct Interaction with the Activation Domain of MyoD and with the MADS Box of MEF2C

1997 • 363 citations

Regulation of Distinct Stages of Skeletal Muscle Differentiation by Mitogen-Activated Protein Kinases

1997 • 351 citations

Acetylation of MyoD Directed by PCAF Is Necessary for the Execution of the Muscle Program

1999 • 351 citations

Reduced Differentiation Potential of Primary MyoD−/− Myogenic Cells Derived from Adult Skeletal Muscle

1999 • 344 citations

FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains

1992 • 333 citations

The Muscle Regulatory Factors MyoD and Myf-5 Undergo Distinct Cell Cycle–specific Expression in Muscle Cells

1998 • 308 citations

Signal-specific co-activator domain requirements for Pit-1 activation

1998 • 284 citations

p300 is required for MyoD-dependent cell cycle arrest and muscle-specific gene transcription

1997 • 281 citations

Determination versus differentiation and the MyoD family of transcription factors

1995 • 276 citations

Two domains of MyoD mediate transcriptional activation of genes in repressive chromatin: a mechanism for lineage determination in myogenesis.

1997 • 259 citations

Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells

2000 • 230 citations

Mitogen-activated Protein Kinase Pathway Is Involved in the Differentiation of Muscle Cells

1998 • 216 citations

Nuclear translocation of mitogen-activated protein kinase kinase (MEK1) in response to mitogenic stimulation

1997 • 183 citations

A Novel Regulatory Mechanism in the Mitogen-activated Protein (MAP) Kinase Cascade

1997 • 181 citations

MyoR: A muscle-restricted basic helix–loop–helix transcription factor that antagonizes the actions of MyoD

1999 • 169 citations

Phosphorylation of Nuclear MyoD Is Required for Its Rapid Degradation

1998 • 163 citations

HLH forced dimers: Tethering MyoD to E47 generates a dominant positive myogenic factor insulated from negative regulation by Id

1993 • 157 citations

I-mf, a Novel Myogenic Repressor, Interacts with Members of the MyoD Family

1996 • 137 citations

CREB-binding Protein/p300 Activates MyoD by Acetylation

2000 • 125 citations

Coupling of the cell cycle and myogenesis through the cyclin D1-dependent interaction of MyoD with cdk4

1999 • 124 citations

cdk1- and cdk2-Mediated Phosphorylation of MyoD Ser200 in Growing C2 Myoblasts: Role in Modulating MyoD Half-Life and Myogenic Activity

1999 • 110 citations

p57^Kip2 Stabilizes the MyoD Protein by Inhibiting Cyclin E-Cdk2 Kinase Activity in Growing Myoblasts

1999 • 99 citations

Signaling through Mitogen-Activated Protein Kinase and Rac/Rho Does Not Duplicate the Effects of Activated Ras on Skeletal Myogenesis

1997 • 80 citations

Nuclear Localization of Mitogen-activated Protein Kinase Kinase 1 (MKK1) Is Promoted by Serum Stimulation and G2-M Progression

1999 • 70 citations

Mitogen-Activated Protein Kinase Kinase (MEK) Activity Is Required for Inhibition of Skeletal Muscle Differentiation by Insulin-Like Growth Factor 1 or Fibroblast Growth Factor 2*

1998 • 67 citations

Cyclin E–Cdk2 Phosphorylation Promotes Late G1-Phase Degradation of MyoD in Muscle Cells

2000 • 63 citations

Two nuclear localization signals present in the basic-helix 1 domains of MyoD promote its active nuclear translocation and can function independently.

1995 • 56 citations

Activated Raf inhibits avian myogenesis through a MAPK-dependent mechanism

1999 • 49 citations

Mos Activates Myogenic Differentiation by Promoting Heterodimerization of MyoD and E12 Proteins

1997 • 33 citations

Intramolecular Regulation of MyoD Activation Domain Conformation and Function

1998 • 32 citations

TFIID (TBP) stabilizes the binding of MyoD to its DNA site at the promoter and MyoD facilitates the association of TFIIB with the preinitiation complex

1998 • 31 citations

Mutation of MyoD‐Ser237 abolishes its up‐regulation by c‐Mos

2000 • 10 citations

MyoD binds to Mos and inhibits the Mos/MAP kinase pathway

1999 • 4 citations