p38 Mitogen-activated Protein Kinase Pathway Promotes Skeletal Muscle Differentiation

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle

1977 • 2,070 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage

1991 • 1,564 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family

1998 • 855 citations

MyoD1: A Nuclear Phosphoprotein Requiring a Myc Homology Region to Convert Fibroblasts to Myoblasts

1988 • 839 citations

Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins

1995 • 817 citations

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

1990 • 794 citations

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1997 • 770 citations

Myogenic Vector Expression of Insulin-like Growth Factor I Stimulates Muscle Cell Differentiation and Myofiber Hypertrophy in Transgenic Mice

1995 • 634 citations

BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

1997 • 580 citations

Selective Activation of p38 Mitogen-activated Protein (MAP) Kinase Isoforms by the MAP Kinase Kinases MKK3 and MKK6

1998 • 531 citations

Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6)

1996 • 519 citations

Requirement of MADS Domain Transcription Factor D-MEF2 for Muscle Formation in Drosophila

1995 • 502 citations

Resistance to Apoptosis Conferred by Cdk Inhibitors During Myocyte Differentiation

1996 • 494 citations

Characterization of the Structure and Function of the Fourth Member of p38 Group Mitogen-activated Protein Kinases, p38δ

1997 • 482 citations

Hormones, Growth Factors, and Myogenic Differentiation

1991 • 399 citations

Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)

1997 • 363 citations

Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal

1994 • 348 citations

Regulation of Muscle Differentiation by the MEF2 Family of MADS Box Transcription Factors

1995 • 348 citations

Muscle-specific transcriptional activation by MyoD.

1991 • 347 citations

Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene.

1989 • 326 citations

A Role for the p38 Mitogen-activated Protein Kinase Pathway in Myocardial Cell Growth, Sarcomeric Organization, and Cardiac-specific Gene Expression

1997 • 320 citations

Analysis of the myogenin promoter reveals an indirect pathway for positive autoregulation mediated by the muscle-specific enhancer factor MEF-2.

1992 • 302 citations

MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation.

1990 • 294 citations

p38 Mitogen-activated Protein Kinase-dependent and -independent Intracellular Signal Transduction Pathways Leading to Apoptosis in Human Neutrophils

1998 • 282 citations

Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors.

1993 • 267 citations

Myogenin induces the myocyte-specific enhancer binding factor MEF-2 independently of other muscle-specific gene products.

1991 • 264 citations

Two domains of MyoD mediate transcriptional activation of genes in repressive chromatin: a mechanism for lineage determination in myogenesis.

1997 • 259 citations

hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors.

1993 • 234 citations

MKK6 Activates Myocardial Cell NF-κB and Inhibits Apoptosis in a p38 Mitogen-activated Protein Kinase-dependent Manner

1998 • 227 citations

Mitogen-activated Protein Kinase Pathway Is Involved in the Differentiation of Muscle Cells

1998 • 216 citations

Use of a conditional MyoD transcription factor in studies of MyoD trans-activation and muscle determination.

1993 • 187 citations

Expression of Bacterial β-Galactosidase in Animal Cells

1982 • 177 citations

A Dominant-Negative Form of Transcription Factor MEF2 Inhibits Myogenesis

1997 • 130 citations

Insulin Activates a p21-activated Kinase in Muscle Cells via Phosphatidylinositol 3-Kinase

1996 • 127 citations

jun N-terminal Kinase Mediates Activation of Skeletal Muscle Glycogen Synthase by Insulin in Vivo

1996 • 109 citations

Expression of Bacterial β-Galactosidase in Animal Cells

1982 • 79 citations

How can we help students learn respiratory physiology?

1997 • 12 citations